HOME >> MEDICINE >> NEWS
Why prostate cancer homes to bone

One of the mysteries surrounding prostate cancer has been its seeming predilection for bone. Is this because other tissues are not amenable to its advances or does bone send out some sort of homing signal that draws the metastasizing cells? Scientists at the National Institute of Dental and Craniofacial Research (NIDCR) now have convincing evidence that a substance in bone not only attracts the prostate cancer cells, but stimulates them to become invasive. This finding has important implications for the discovery and development of agents that might be used in the treatment of prostate cancer and other cancers that spread to bone.

Prostate cancer is the second leading cause of cancer deaths in men from both Europe and the United States. At the time of diagnosis, over 70 percent of the cases have metastasized to the pelvic lymph nodes. From there, cancerous cells show a high propensity for invading bone in the pelvis and vertebra of the lower back.

The question has been why bone rather than nearby organs like kidney, liver, or even lung. One theory has been coined "seed and soil," which likens cancer cells to seeds drifting in the wind and landing at random on different types of soil--putting down roots only where the local conditions allow. Another theory portrays cancer more like a predatory animal that is drawn by the trail of its favorite prey.

Drs. Karin Jacob and Hynda Kleinman from NIDCR's Craniofacial Developmental Biology and Regeneration Branch led an international research team to determine if there was a specific factor in bone that acts as an attractant for prostate and possibly other bone-seeking cancers, such as breast cancer. By studying the reaction of prostate cancer cells to various solutions of tissue extract, they found that a bone protein caused the cells to aggressively migrate to the bone extract. The study appears in the September 1 issue of Cancer Research.

The investigators used a technique developed by Dr. Klein
'"/>

Contact: Wayne Little
wayne.little@nih.gov
301-496-4261
NIH/National Institute of Dental and Craniofacial Research
1-Sep-1999


Page: 1 2 3

Related medicine news :

1. Hormonal treatment improves survival in high-risk prostate cancer patients
2. Cultural and social factors influence prostate cancer treatment
3. Earlier use of prostate cancer vaccines urged by Hopkins scientists
4. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
5. Men more likely to get screened for prostate cancer than colon cancer, U-M study finds
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Obesity may affect accuracy of prostate screening
8. More precise radiation therapy lets prostate cancer patients avoid erectile dysfunction
9. Combining hormones with external, internal radiation helps high risk prostate cancer patients
10. Silent risk of osteoporosis in men with prostate cancer
11. NIH launches new study to compare prostate surgery and drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology:
Cached News: