HOME >> MEDICINE >> NEWS
Widely used treatment for head injuries found to be harmful

This release is also available in German.

The use of anti-inflammatory drugs to treat patients with severe head injuries--common practice worldwide for the past 30 years--is actually dangerous and associated with around a 20% increase in death within two weeks of hospital admission, conclude authors of an international study in this week's issue of THE LANCET.

Around 3 million people worldwide die of trauma every year, many after arrival at hospital. Findings of a 1997 systematic review suggested that these drugs might reduce the risk of death by a few percent; previous individual trials had been too small to provide a clear-cut answer. The CRASH trial (corticosteroid randomisation after significant head injury)--a multicentre international collaboration--aimed to confirm or refute such an effect by recruiting 20,000 patients. In May, 2004, the data monitoring committee disclosed the unmasked results to the steering committee, which stopped recruitment to the trial.

10,008 adults (from 239 hospitals in 49 countries) with head injury were randomly allocated corticosteroids (methylprednisolone) or placebo for 48 hours after admission to a hospital emergency department. Those patients given corticosteroids had a higher death rate within 2 weeks (21% of patients) than those given placebo (18%). The 6-month follow-up data will be presented in a subsequent paper.

Clinical co-ordinator of the study Professor Ian Roberts (London school of Hygiene and Tropical Medicine, UK) comments: "Our early results show that corticosteroids should not be used routinely to treat head injury, whatever the severity. By clearly refuting a mortality benefit from corticosteroids in head injury, the CRASH trial results should protect many thousands of patients from any increased risk of death associated with these drugs... The effect of corticosteroid treatment on disability 6 month
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
7-Oct-2004


Page: 1 2

Related medicine news :

1. Widely used breast cancer drug not linked to stroke
2. Widely used anti-nausea drug may interfere with cancer chemotherapy
3. Widely used anti-bacterial inhibits parasites that cause malaria and toxoplasmosis
4. Newest Depression Medications Widely Prescribed For Children
5. Widely Used Therapy May Not Be Effective In Treatment Of Acute Stroke
6. Personality, Thought To Be Stable Over Time, Changes In Healthy People Who Take A Widely Used Anti-Depressant
7. Hormonal treatment improves survival in high-risk prostate cancer patients
8. Chronic pain treatments more effective when taken together, new study shows
9. Brain activity prior to treatment flags vulnerability to antidepressant side effects
10. Cultural and social factors influence prostate cancer treatment
11. Research offers hope of new treatments for liver damage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/16/2019)... ... 15, 2019 , ... As demand for legal medical marijuana ... well-managed dispensaries becomes more and more important, both for consumers and as part ... online, custom cannabis business plans is now increasing its support for marijuana dispensary ...
(Date:11/15/2019)... ... November 15, 2019 , ... Spectrum Vision Partners claimed ... Island Workplaces for 2019. The recently announced rankings honor those organizations where employees ... in partnership with Energage to conduct surveys into organizational health and identify Long ...
(Date:11/14/2019)... ... November 14, 2019 , ... EMulate Therapeutics, Inc., a clinical-stage ... it will have 5 poster presentations related to its medical devices for treating ... SNO Meeting in Phoenix, beginning on November 20 . , Two ...
(Date:11/12/2019)... ... 12, 2019 , ... Each year, RESOLVE (The National Infertility ... diagnosed with infertility. This year, Academy of Adoption and Assisted Reproduction Attorneys ("AAAA") ... Night of Hope Gala in New York City on November 11, 2019. AAAA ...
(Date:11/12/2019)... ... November 12, 2019 , ... Raintree Rehab, a division of ... and rehabilitation operators throughout the United States and Physitrack, an Apple Mobility Partner ... announces a joint venture to develop and market clinical outcomes data solutions. , ...
Breaking Medicine News(10 mins):
(Date:11/19/2019)... ... November 19, 2019 , ... Respected ... television program “Behind The Scenes” with Laurence Fishburne. The program’s central focus is ... society. In an imminent episode to be aired on the show, a new ...
(Date:11/16/2019)... , ... November 16, 2019 , ... International Splash Awards ... Tools and Apps category. , Srijan got nominated for its efforts at the ... commendable work for Estee Lauder under tools and apps category. The event was organized ...
(Date:11/16/2019)... ... November 15, 2019 , ... ... impairment, has announced the Best Memory Care Facilities in Columbus, Ohio. The guide ... and amenities. , According to the Alzheimer’s Association , 5.6 million ...
Breaking Medicine Technology:
Cached News: