HOME >> MEDICINE >> NEWS
Winning the battle of the bulge: We're a scrimmage closer to victory

ST. LOUIS -- Saint Louis University researchers believe they've won a major skirmish in the battle of the bulge, and their findings are published in the May issue of Diabetes.

"We figured out how obesity occurs," says William A. Banks, M.D., professor of geriatrics in the department of internal medicine and professor of pharmacological and physiological science at Saint Louis University School of Medicine. "The next step is coming up with the solution."

The scientists used mice to look at how leptin, a hormone secreted by fat cells that tells us to stop eating, gets into the brain. They found that in obese mice, high triglycerides, a type of fat in the bloodstream, prevents leptin from getting into the brain, where it can do its work in turning off feeding and burning calories.

"High triglycerides are blocking the leptin from getting into the brain. If leptin can't get into the brain, it can't tell you to stop eating," says Banks, who is principal investigator and a staff physician at Veterans Affairs Medical Center in St. Louis.

"This is a big deal. We now know what is keeping leptin from getting to where it needs to do its work."

Paradoxically high triglycerides occur in both fat and starving animals and make the brain think the body's starving so the animal keeps eating, which makes it gain more weight.

"We figured out why the troops aren't getting to the front. There is all of this leptin in the blood but it isn't getting to the brain because triglyerides are impairing the transportation system.

"We feel that we now understand what part of the system is broken - why leptin isn't working. We have a better understanding of why people are becoming obese," Banks says.

The research points scientists to a new direction in solving the obesity epidemic.

"Lowering triglyceride levels may very well be a big part of the answer," Banks says. "This is a reasonable deduction that should be tested."
'"/>

Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
27-Apr-2004


Page: 1 2

Related medicine news :

1. Chemists synthesize molecule that helps body battle cancers, malaria
2. Abandoned bones suggest TB wiped out leprosy in battle of killer diseases
3. Mayo Clinic recommends broadening treatment to battle recurrence of endometrial cancer
4. University of Manchester uses crystals to help battle deadly diseases
5. Study: Brain battles itself over short-term rewards, long-term goals
6. UCSD partners with Peru in NIH grant to battle malaria, worlds number 2 killer
7. New molecule may be basis for drugs that battle overeating and drug dependency
8. Univeristy of Utah anesthesiologists on front lines in battle against post-operative pain
9. Space science joins battle against cancer
10. Book explores how children use imagination to battle chronic illness
11. Researchers battle drug-resistant HIV on promising new ground

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... One of two inventors from Glen Burnie, Md., ... painful for her. "This is why the co-inventor and I have designed a new ... then created a prototype of the patent-pending AV-AIR, a device that serves as an ...
(Date:12/7/2016)... ... December 07, 2016 , ... The ... its fully redesigned website, which launched October 17, 2016, features comprehensive information regarding ... and easy-to-navigate layout. Visitors and patients can discover the latest clinical dermatology treatments ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... The ... the holidays and winter seasons. One major study analyzing heart attacks among 138,602 ... to August of a given year. We would all agree of course–no time of ...
(Date:12/7/2016)... ... December 07, 2016 , ... “The Road To Restoration”: ... trial, not a one hour a week showing of hands. “The Road To Restoration” ... begins, “Perhaps you are familiar with the brass ring that you could reach out ...
(Date:12/7/2016)... ... December 07, 2016 , ... The Business ... Summit in Reston, VA on March 21-22, 2017. This premier event features business ... experiences from a cross-section of industries such as financial services, insurance, healthcare, manufacturing, ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... N.Y. , Dec. 6, 2016  Licenders is bringing their ... This new location in Park Slope at 203 13 th ... Brooklyn clientele. "Our goal is to ... treatment plans are designed to get children right back to class ... are 100% all natural and safe for the whole family," Licenders ...
(Date:12/6/2016)... LONDON , Dec. 6, 2016  "Blood ... all cancers announced ....." The Diagnostic, Monitoring ... revolution in cancer diagnostics is occurring using in ... a new company with impressive backing, has announced ... The technology is moving faster than the market. ...
(Date:12/6/2016)... -- Diabetes & Obesity Drug Development Pipeline Review, 2016 ... is currently dominated by therapeutics indicated for type 1 ... and the majority of the pipeline, in terms of ... these indications. While products indicated for obesity do not ... large number of these products in the pipeline, with ...
Breaking Medicine Technology:
Cached News: