HOME >> MEDICINE >> NEWS
Winning the battle of the bulge: We're a scrimmage closer to victory

ST. LOUIS -- Saint Louis University researchers believe they've won a major skirmish in the battle of the bulge, and their findings are published in the May issue of Diabetes.

"We figured out how obesity occurs," says William A. Banks, M.D., professor of geriatrics in the department of internal medicine and professor of pharmacological and physiological science at Saint Louis University School of Medicine. "The next step is coming up with the solution."

The scientists used mice to look at how leptin, a hormone secreted by fat cells that tells us to stop eating, gets into the brain. They found that in obese mice, high triglycerides, a type of fat in the bloodstream, prevents leptin from getting into the brain, where it can do its work in turning off feeding and burning calories.

"High triglycerides are blocking the leptin from getting into the brain. If leptin can't get into the brain, it can't tell you to stop eating," says Banks, who is principal investigator and a staff physician at Veterans Affairs Medical Center in St. Louis.

"This is a big deal. We now know what is keeping leptin from getting to where it needs to do its work."

Paradoxically high triglycerides occur in both fat and starving animals and make the brain think the body's starving so the animal keeps eating, which makes it gain more weight.

"We figured out why the troops aren't getting to the front. There is all of this leptin in the blood but it isn't getting to the brain because triglyerides are impairing the transportation system.

"We feel that we now understand what part of the system is broken - why leptin isn't working. We have a better understanding of why people are becoming obese," Banks says.

The research points scientists to a new direction in solving the obesity epidemic.

"Lowering triglyceride levels may very well be a big part of the answer," Banks says. "This is a reasonable deduction that should be tested."
'"/>

Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
27-Apr-2004


Page: 1 2

Related medicine news :

1. Chemists synthesize molecule that helps body battle cancers, malaria
2. Abandoned bones suggest TB wiped out leprosy in battle of killer diseases
3. Mayo Clinic recommends broadening treatment to battle recurrence of endometrial cancer
4. University of Manchester uses crystals to help battle deadly diseases
5. Study: Brain battles itself over short-term rewards, long-term goals
6. UCSD partners with Peru in NIH grant to battle malaria, worlds number 2 killer
7. New molecule may be basis for drugs that battle overeating and drug dependency
8. Univeristy of Utah anesthesiologists on front lines in battle against post-operative pain
9. Space science joins battle against cancer
10. Book explores how children use imagination to battle chronic illness
11. Researchers battle drug-resistant HIV on promising new ground

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... ... April 28, 2016 , ... ... today the open availability of a new CDISC standard, Clinical Trial Registry ... clinical trials. This innovative standard will make it possible to build applications ...
(Date:4/28/2016)... Beach, FL (PRWEB) , ... April 28, 2016 , ... ... the spring season. Smart pots are frequently used by professional organic farmers and nurseries ... growers to order their supply of fabric pots. Our goal is to offer wholesale ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... Center Infrastructure Management solutions, announces today the availability of its latest software ... area of capacity management and optimization, providing new analytical capabilities that assess ...
(Date:4/28/2016)... , ... April 28, 2016 , ... USA Medical Card reminds us that May is ... a stroke is the fourth leading cause of death in the United States; someone has ... a quarter of them in individuals under 65 years old. A stroke is when ...
(Date:4/28/2016)... MA (PRWEB) , ... April 28, 2016 , ... A ... were typical among 18 states studied, the Workers Compensation Research Institute (WCRI) ... The WCRI study, CompScope™ Benchmarks for Kentucky, 16th Edition , found that indemnity ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 28, 2016 TapImmune,Inc. (TPIV), ... peptide and gene-based immunotherapeutics and vaccines for the treatment of ... at the 3rd Annual Growth Capital Expo to ... 2016 at Caesars Palace in Las Vegas, Nevada.  The ... May 4 th by Dr. John N. Bonfiglio ...
(Date:4/27/2016)... Avril 2016   ... +5% sur le trimestre, soutenu par une croissance ... Croissance de +16% des ventes aux hôpitaux ... Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur ... aujourd,hui son chiffre d,affaires pour le premier trimestre ...
(Date:4/27/2016)... Conn. , April 27, 2016   ... of its digital health technology platform, which specializes ... and programs into scalable digital products, Zillion enables ... engagement and empower consumers to take control of ... face-to-face live video conferencing – including one-to-one, group ...
Breaking Medicine Technology:
Cached News: