HOME >> MEDICINE >> NEWS
Winning the battle of the bulge: We're a scrimmage closer to victory

ST. LOUIS -- Saint Louis University researchers believe they've won a major skirmish in the battle of the bulge, and their findings are published in the May issue of Diabetes.

"We figured out how obesity occurs," says William A. Banks, M.D., professor of geriatrics in the department of internal medicine and professor of pharmacological and physiological science at Saint Louis University School of Medicine. "The next step is coming up with the solution."

The scientists used mice to look at how leptin, a hormone secreted by fat cells that tells us to stop eating, gets into the brain. They found that in obese mice, high triglycerides, a type of fat in the bloodstream, prevents leptin from getting into the brain, where it can do its work in turning off feeding and burning calories.

"High triglycerides are blocking the leptin from getting into the brain. If leptin can't get into the brain, it can't tell you to stop eating," says Banks, who is principal investigator and a staff physician at Veterans Affairs Medical Center in St. Louis.

"This is a big deal. We now know what is keeping leptin from getting to where it needs to do its work."

Paradoxically high triglycerides occur in both fat and starving animals and make the brain think the body's starving so the animal keeps eating, which makes it gain more weight.

"We figured out why the troops aren't getting to the front. There is all of this leptin in the blood but it isn't getting to the brain because triglyerides are impairing the transportation system.

"We feel that we now understand what part of the system is broken - why leptin isn't working. We have a better understanding of why people are becoming obese," Banks says.

The research points scientists to a new direction in solving the obesity epidemic.

"Lowering triglyceride levels may very well be a big part of the answer," Banks says. "This is a reasonable deduction that should be tested."
'"/>

Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
27-Apr-2004


Page: 1 2

Related medicine news :

1. Chemists synthesize molecule that helps body battle cancers, malaria
2. Abandoned bones suggest TB wiped out leprosy in battle of killer diseases
3. Mayo Clinic recommends broadening treatment to battle recurrence of endometrial cancer
4. University of Manchester uses crystals to help battle deadly diseases
5. Study: Brain battles itself over short-term rewards, long-term goals
6. UCSD partners with Peru in NIH grant to battle malaria, worlds number 2 killer
7. New molecule may be basis for drugs that battle overeating and drug dependency
8. Univeristy of Utah anesthesiologists on front lines in battle against post-operative pain
9. Space science joins battle against cancer
10. Book explores how children use imagination to battle chronic illness
11. Researchers battle drug-resistant HIV on promising new ground

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... ... March 24, 2017 , ... ... (ONS) wanted to create a communications platform that positions them as the go-to ... and ONS reinvented their online publication as an always-on, always-fresh news, views and ...
(Date:3/24/2017)... ... March 24, 2017 , ... The law firm of ... is pleased to announce Westchester resident Lauren C. Enea has joined the firm as ... firm, will concentrate her practice in elder law, Medicaid planning and applications, and Wills, ...
(Date:3/24/2017)... ... March 24, 2017 , ... Empower Brokerage, ... their training and leads programs. , In February, 2017, Empower Brokerage introduced their ... Performance Partners is designed to teach how to maximize their sales efforts, as ...
(Date:3/24/2017)... ... 2017 , ... “End Time GPS”: a dauntless and enlightened study of ... GPS” is the creation of published author, Wesley Gerboth, a World War II veteran, ... space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God bestowed upon him ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog ... dog who lives his life to the fullest, as God intended. “The Adventures of ... Holmgren, a mother and grandmother pursuing her passion for writing, especially about truth and ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)...   The Accreditation Council for Medical Affairs ... the pharmaceutical industry has appointed Dr. Jane ... formed scientific advisory board. Dr. Chin will be ... ever medical affairs think tank within the pharmaceutical ... ACMA, please visit  www.medicalaffairsspecialist.org .  Connect with ...
(Date:3/24/2017)... FinancialBuzz.com News Commentary  ... According to new data published Arcview ... legal cannabis market is projected to continue to grow at ... the current presidential administration. The report created by Arcview,s data ... growth in this industry are the passage and subsequent implementation ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of the ... their offering. ... pipeline is very strong with a total of 97 drug candidates. Pharma ... Sanofi are involved in the development of the IPF therapeutics. The IPF ... III stage, 15 are in Phase II stage, 12 are in Phase ...
Breaking Medicine Technology:
Cached News: