With cues from nature, scientists develop new method to purify drugs

GAINESVILLE, Fla. --- Using what might be described as a biological machine, University of Florida and Finnish researchers have demonstrated an experimental process for drug purification that one day could speed the production and decrease the cost of prescription drugs.

The researchers created antibodies that recognized and attached to a cancer-fighting drug molecule. They installed the antibodies in almost unimaginably small silica tubes, known as nanotubes, arranged in a membrane. In an experiment reported Friday in an article in the journal Science, the "smart membrane" transmitted the drug molecule far faster than other molecules in a mixture.

"What's new here is that we chemists have borrowed a couple of pages from the natural world to demonstrate the potential for a new approach for purifying drugs," said Charles Martin, a UF professor of chemistry and the lead author of the article.

Drug makers use several techniques to make antibiotics, chemotherapy drugs and other widely used pharmaceuticals. A common method is to nurture and grow bacteria that produce the desired drug molecule in a mixture. The hitch is this mixture also may contain tens or hundreds of unwanted and potentially harmful molecules or materials, sometimes including the bacteria themselves. As a result, the drug has to be separated from the mixture, or purified, a slow and expensive process.

The workhorse technology now used for purifying drugs, called chromatography, involves letting the mixture flow slowly down a column. Different compounds descend at different speeds, so as a mixture drips down the column, its molecules separate into pure bands. The desired drug can then be captured as a purified band. The process requires considerable use of expensive solvents and also is difficult to use for large-scale production. As a result, researchers have for some time discussed replacing chromatography with a membrane that would automatically capture the desired

Contact: Charles Martin
University of Florida

Page: 1 2 3

Related medicine news :

1. Mini-motor models nature, advances miniaturization technology
2. OHSU scientists test medication to treat involuntary weight loss
3. Earlier use of prostate cancer vaccines urged by Hopkins scientists
4. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
5. Schepens scientists regenerate optic nerve for the first time
6. OHSU scientists develop MRI approach to improve breast cancer detection
7. UCLA neuroscientists pinpoint new function for mirror neurons
8. Jefferson scientists uncover potential trigger of diabetic kidney disease
9. Johns Hopkins scientists receive presidential medals
10. UCLA brain scientists crack mystery of how alcohol causes intoxication
11. Wisconsin scientists grow critical nerve cells

Post Your Comments:

(Date:1/15/2019)... ... ... Ophthalmic Consultants of Long Island (OCLI), a Spectrum Vision Partners managed practice, ... East Sunrise Highway, Suite 400, Valley Stream, NY 11581. The new location will enable ... D’Aversa, MD, “After serving the Valley Stream community for over 15 years, we are ...
(Date:1/14/2019)... , ... January 14, 2019 , ... ... supplements, household and personal-care products with a presence worldwide, today announced that it ... 2018. Measured year-over-year, Modere sales grew by double-digits in North America, by more ...
(Date:1/14/2019)... ... 2019 , ... Docs Proudly Presents All Reviewed & Approved Living Well Providers of 2019. , Acupuncture, ... Dr. Edward Izrailov - Maplewood , Dr. Joanna Jodar - Somerset , ... Robert Lenahan - Point Pleasant , Dr. Robert J. Reinhardt - Pequannock , ...
(Date:1/13/2019)... ... ... IL Top Docs Include: , ANESTHESIOLOGY, Dr. Adam Block , ... Dr. Marcie Claybon , NEPHROLOGY, Dr. Naila Ahmed ... Dr. Aarathi Cholkeri-Singh , PEDIATRICS, Dr. ...
(Date:1/11/2019)... ... January 11, 2019 , ... Women’s Excellence Obstetrics and ... Dr. Jonathan Zaidan, President of Women’s Excellence, will co-host WJR’s "Health Women Show" ... each month at 7pm. , "We are excited to partner with a longstanding, ...
Breaking Medicine News(10 mins):
(Date:1/15/2019)... ... January 15, 2019 , ... Dr. Evan Ransom is ... Facial Plastic and Reconstructive Surgeon . As the lead surgeon and director ... California, Dr. Ransom serves patients with a personal philosophy to preserve the unique ...
(Date:1/14/2019)... ... ... The Villas at Heritage Woods of Centralia is celebrating 10 years of service ... Jan. 16. , “Since the beginning, The Villas has established itself as a wonderful ... that manages the community. , During the anniversary celebration, Administrator Tom Broughton will ...
(Date:1/11/2019)... (PRWEB) , ... January 11, 2019 , ... Proven entrepreneur ... gyms across the United States by 2024. Hartl, who previously built the Planet ... Killeen and Waco , Texas. , “It’s why I came out ...
Breaking Medicine Technology:
Cached News: