HOME >> MEDICINE >> NEWS
Women with PCOS and their siblings with hormone problems have same gene defect

CHICAGO --- Siblings of women with polycystic ovary syndrome (PCOS) have metabolic and hormonal abnormalities that are linked to the same gene defect that causes PCOS, a disorder associated with irregular periods, infertility, excessive body hair and increased risk for diabetes.

These new findings came from the $6 million National Institutes of Health-funded National Centers Program for Infertility Research. The study was led by Northwestern University researcher Andrea Dunaif, M.D., Charles F. Kettering Professor, chief of endocrinology and metabolism and professor of medicine at The Feinberg School of Medicine, and collaborators at Pennsylvania State University and the University of Pennsylvania.

Dunaif and co-investigators believe the location of the PCOS gene mutation is on chromosome 19, near the insulin receptor gene, which plays a key role in allowing insulin to enter cells and metabolize sugar. This marker, called allele 8 of D19S884, was associated with risk factors for diabetes in PCOS women and their brothers.

In recently published studies, approximately 50 percent of the sisters of PCOS women had elevated androgen (so-called "male hormones" that are present in both men and women) levels while the other half of the sisters were unaffected. Of the high-androgen group, half (or 25 percent of the sisters) had PCOS and insulin resistance, while the other 25 percent were insulin resistant but showed no PCOS symptoms and had normal menstrual periods.

The PCOS sisters and those with high androgen levels were more obese than unaffected sisters.

The PCOS brothers also had significantly elevated levels of the androgen DHEAS, which correlated with the high androgen levels in their sisters with PCOS.

These results strongly suggest that the same gene defect is responsible for PCOS and the hormonal abnormalities and other symptoms found in the siblings of PCOS-affected women, but further studies are required, Du
'"/>

Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
12-Aug-2002


Page: 1 2

Related medicine news :

1. The European Society of Cardiology launches Women at Heart
2. Women less likely to get quality heart attack care
3. Statement on the findings of the Womens Health Study
4. Women should be advised not to drink alcohol in pregnancy
5. Women with thyroid problem have lower risk of breast cancer
6. Women successfully treated to prevent preterm labor at low risk for recurrent episode
7. Womens heart risk underestimated by doctors, resulting in less preventive care than in men
8. Women, drinking to their health
9. Women want annual pap smears
10. Women In Government report on eliminating cervical cancer
11. Women need less morphine after hysterectomies with new treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: