Over a century ago physicians described using thyroid extract to treat breast cancer. Later, studies found that one of the circulating thyroid hormones actually sustained breast cancer cells, while animal studies found mammary gland cells responded to thyroid hormones. Population studies have shown conflicting patterns in the relationship between thyroid hormone and breast cancer. For example, Japanese scientists found patients with thyroiditis an elevated thyroid hormone state had a higher incidence of breast cancer, while other scientists found high levels of thyroid hormones were protective against breast cancer. Studies of benign thyroid disorders have also failed to demonstrate associations between thyroid hormones and breast cancer biology.
To investigate and clarify the relationship between a history of hypothyroidism and the risk of breast cancer, Massimo Cristofanilli, M.D. and colleagues at the University of Texas M. D. Anderson Cancer Center in Houston compared the medical records from 1136 women with breast cancer and 1088 healthy women attending their breast screening clinic.
The researchers found women with primary hypothyroidism had a 61 percent lower risk of developing invasive breast cancer. In addition, women with breast cancer were 57 percent less likely to have hypothyroidism
Contact: David Greenberg
John Wiley & Sons, Inc.