HOME >> MEDICINE >> NEWS
Work on promising inorganic blood substitute to move forward with $1.5 million grant from NIH

BUFFALO, N.Y. -- A patient who is losing large amounts of blood presents a medical emergency, requiring proper blood-typing and immediate access to multiple units of compatible blood.

Health workers must hope that transfusing large amounts of blood doesn't add to the emergency and that the patient has no objection to receiving blood products. Then there are the cost and logistics of maintaining large stocks of blood at the ready.

The solution to these problems may lie in an inorganic compound with the cumbersome name dodecaflouropentane emulsion, or DDFPe, a fluorocarbon-based compound used originally as a contrast medium for taking ultrasound images that University at Buffalo researchers are developing as a blood substitute.

Claes Lundgren, M.D., Ph.D., professor in the Department of Physiology and Biophysics in the UB School of Medicine and Biomedical Sciences, is principal researcher on a new $1.5 million, four-year grant from the National Institutes of Health to fund work to define further the compound's use for this purpose.

Lundgren holds up a vial containing the milky emulsion that is half the size of a roll of breath mints. "These five milliliters would be adequate to save the life of a child weighing 10-15 kilograms [26-40 pounds] who had lost half his/her blood supply," he said.

Hugh Van Liew, Ph.D., UB professor emeritus of physiology, and Mark Burkard, Ph.D., who worked with Van Liew as his research assistant, did the initial work to establish DDFPe's use as an oxygen transporter. Lundgren, Van Liew, Burkard and Ingvald Tyssebotn, M.D., Ph.D., UB professor of physiology and biophysics, hold the patent on the product's use as a blood substitute.

The key to this product's ability to prevent hemorrhagic shock lies in the capacity of the emulsion's invisible droplets to expand at body temperature into microbubbles small enough to pass through capillaries, and the strong affinity of the microbubbles for oxygen. If sufficie
'"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
15-Apr-2004


Page: 1 2

Related medicine news :

1. Another look finds promising proteomics test is not biologically plausible
2. Inflammatory cells highly promising target in NF 1
3. Drug treatment promising for halting Huntingtons-related nerve death
4. Triple-drug therapy promising against African HIV subtype
5. Mayo Clinic researchers announce promising next generation treatments for multiple myeloma
6. Outpatient lung cancer procedure promising for inoperable disease
7. PET scanning promising in diagnosing cancer-related neurological disorders
8. Preliminary results are promising in Alzheimers gene therapy trial
9. Fertility herbal supplement sprouts promising results in Stanford pilot study
10. NIH researchers test promising new therapy for blinding eye disease
11. University Of Pittsburgh Medical Center studying promising new imaging technology

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2019)... ... April 17, 2019 , ... Kadan Homecare, an award-winning ... announced today that it has received both the 2019 Best of Home Care® – ... are granted only to the top-ranking home care providers, based on client and caregiver ...
(Date:4/17/2019)... HAVEN, Conn. (PRWEB) , ... April 17, 2019 ... ... community for IBS sufferers, announced a new initiative this April to designate April ... and to show strong support for research & healthcare professionals in their pursuit ...
(Date:4/17/2019)... ... April 17, 2019 , ... Fertility Centers of Illinois ... an effort to unite millions of Americans aiming to remove the stigmas and ... initiative, Fertility Centers of Illinois is offering seven free physician-led webinars and free ...
(Date:4/17/2019)... ... April 17, 2019 , ... An upcoming episode of Innovations ... episode is scheduled to air 3Q 2019 on FOX Business. Check your local ... Biomedical Pte. Ltd. (Credo Biomedical), a molecular diagnostic company from Singapore dedicated to ...
(Date:4/17/2019)... ... 17, 2019 , ... Signaled.online is a notification service designed for personal use. ... the web resources and reminder. , The alarm can be useful while traveling abroad, ... you haven’t logged in to the website for several days (this period is set ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... ... April 17, 2019 , ... ... therapies for diseases involving mitochondrial dysfunction, announced yesterday at the 2019 Muscular ... TAZPOWER and open-label extension (OLE) clinical trial evaluating efficacy of elamipretide, an ...
(Date:4/17/2019)... (PRWEB) , ... April 17, 2019 , ... ... Inc., (NYSE:VTR) and one of the nation’s largest owners and operators of medical ... of 11 healthcare industry experts during the Building Owners and Managers Association (BOMA) ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... Clinical Trial Design Strategies to Expedite Development of Oncology Drugs and Biologics’ ... alike. , Through years of experience helping sponsors manage complex oncology trials, ...
Breaking Medicine Technology:
Cached News: