Authors of a study to be published on THE LANCET's website http://www.thelancet.com which forms the basis of this year's World health Report 2002 conclude that worldwide health can be substantially improved if individuals and government's address the main risk factors that are responsible for the global health burden.

A clear understanding of the major risk factors to health is crucial for public-health planning and the prevention of disease and disability. Christopher Murray, Majid Ezzati and colleagues from the World Health Organisation (WHO) aimed to estimate the contributions of selected major risk factors to global and regional burden of disease.

For 25 selected risk factors - including malnutrition, access to safe water and sanitation, high blood pressure, high cholesterol concentrations, unsafe sex, tobacco and alcohol consumption--expert WHO working groups undertook a comprehensive review of published work and other sources (such as government reports and international databases) to obtain data on the prevalence of risk-factor exposure and hazard size for 14 regions of the world.

Childhood and maternal underweight (9.5%), unsafe sex (6.3%), high blood pressure (4.4%), tobacco (4.1%), and alcohol (4.0%) were the leading causes of global burden of disease. In the poorest regions of the world, childhood and maternal underweight, unsafe sex, unsafe water, sanitation, and hygiene, indoor smoke from solid fuels, and various micronutrient deficiencies (eg. Iron, zinc, and vitamin A deficiency), were major contributors to loss of healthy life. In both developing and developed regions, alcohol, tobacco, high blood pressure, and high cholesterol were major causes of disease burden.

In an accompanying Commentary, John Powles and Nick Day from the Institute of Public Health, Cambridge, UK, assess how realistic it may prove to reduce certain risk factors. They comment: "Increasing fruit and vegeta
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Contact: Richard Lane
richard.lane@lancet.com
44-0-207-424-4949
Lancet
30-Oct-2002