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Yale study of long-term learning deficits resulting from repeated amphetamine exposure could help drug abusers

gs such as cocaine and ecstasy have been found to produce long-lasting and possibly permanent cognitive deficits.

"It may be the case that even a brief period of low-dose amphetamine abuse in early adolescence or early adulthood can produce profound cognitive deficits that may persist for a couple of years or more after amphetamine use has ended," said Castner.

The investigators' ongoing research includes experiments involving neurotransmitters that will help explain the long-lasting cognitive deficits in primates. They are also conducting experiments to reverse the AMPH-induced cognitive deficits in the same group of primates and they plan to investigate the biochemical and structural changes in the primate brain that could account for the behavioral deficits.


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Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
25-Oct-1999


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