HOME >> MEDICINE >> NEWS
Yale study shows way to re-stimulate brain cell growth: Results could boost understanding of Alzheimer's, other brain disorders

New Haven, Conn.--Yale scientists have discovered that the growth of brain cells, which normally ends in adolescence, can be re-stimulated in mature neurons with a molecular mechanism known as Notch signaling.

Because Notch signaling also may be involved in the progression of degenerative diseases like Alzheimer's, the results published in the October 22 issue of Science could help scientists find ways to treat, or even prevent, this and other brain disorders.

"Our results not only help in our understanding of brain development, but they also have considerable implications for designing new treatments for many neurological disorders," said Pasko Rakic, M.D., the study's principal investigator.

"One of the hallmarks of Alzheimer's disease is the alteration of brain cell processes that can lead to irreversible memory loss and cognitive abilities characteristic of the disorder," Rakic said. "While we are still trying to determine what role Notch signaling plays in Alzheimer's, the results of this study could open possibilities for treating and preventing these kinds of brain disorders."

As the brain develops, neurons grow rapidly by extending neurites--dendrites and axons--which make millions of connections from birth up until adolescence, when the connections in the cerebral cortex begin to stabilize. As stabilization occurs, long term memory is acquired, allowing people to remember things throughout their lives. This new study provides a clue to how the transition from growth to stability might occur.

"We have identified the signaling pathway involved in the switch from growth to stability, as well as the associated molecules that can turn the switch on and off," said Rakic, professor and chair of neurobiology at Yale Medical School.

The main element of the signaling pathway is the Notch receptor, which was first described in studies at Yale in the 1940s and was then cloned at Yale in the 1980s, but its role in adult brain cells has
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
18-Oct-1999


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... 12, 2017 , ... CitiDent and San Francisco dentists, Dr. ... Oventus O2Vent technology. As many as 18 million Americans are estimated to suffer ... Oral appliances can offer significant relief to about 75 percent of people with ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... 12, 2017 , ... HMP , a leader in healthcare events and ... Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie ... annual award competition recognizes editorial and design excellence across a range of sectors. This ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... their devotion to personalized service, SMP Pharmacy Solutions announces their ... South Florida Business Journal,s 50 Fastest-Growing Companies, and listed for ... specialty pharmacy has found its niche.  To that end, the ... by SFBJ as the 2017 Power Leader in Health Care. ... award in October, Bardisa said of the three achievements, "It,s ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., a ... design, and immune-engineering today announced the launch of ... development of personalized therapeutic cancer vaccines. EpiVax has ... exclusive access to enabling technologies to the new ... will lead EpiVax Oncology as Chief Executive Officer. ...
(Date:9/22/2017)... 22, 2017 AVACEN Medical (AVACEN) announced that ... successfully helping those with the widespread pain associated with ... Amanda in Essex, England commented, ... hair, experiencing no sleep at all, tremendous pain, with ... cannot recommend [the AVACEN 100] enough, how this has ...
Breaking Medicine Technology:
Cached News: