HOME >> MEDICINE >> NEWS
Yale study shows way to re-stimulate brain cell growth: Results could boost understanding of Alzheimer's, other brain disorders

New Haven, Conn.--Yale scientists have discovered that the growth of brain cells, which normally ends in adolescence, can be re-stimulated in mature neurons with a molecular mechanism known as Notch signaling.

Because Notch signaling also may be involved in the progression of degenerative diseases like Alzheimer's, the results published in the October 22 issue of Science could help scientists find ways to treat, or even prevent, this and other brain disorders.

"Our results not only help in our understanding of brain development, but they also have considerable implications for designing new treatments for many neurological disorders," said Pasko Rakic, M.D., the study's principal investigator.

"One of the hallmarks of Alzheimer's disease is the alteration of brain cell processes that can lead to irreversible memory loss and cognitive abilities characteristic of the disorder," Rakic said. "While we are still trying to determine what role Notch signaling plays in Alzheimer's, the results of this study could open possibilities for treating and preventing these kinds of brain disorders."

As the brain develops, neurons grow rapidly by extending neurites--dendrites and axons--which make millions of connections from birth up until adolescence, when the connections in the cerebral cortex begin to stabilize. As stabilization occurs, long term memory is acquired, allowing people to remember things throughout their lives. This new study provides a clue to how the transition from growth to stability might occur.

"We have identified the signaling pathway involved in the switch from growth to stability, as well as the associated molecules that can turn the switch on and off," said Rakic, professor and chair of neurobiology at Yale Medical School.

The main element of the signaling pathway is the Notch receptor, which was first described in studies at Yale in the 1940s and was then cloned at Yale in the 1980s, but its role in adult brain cells has
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
18-Oct-1999


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
(Date:4/27/2015)... (PRWEB) April 27, 2015 On May 5, ... will ask their social media friends around the world to ... as asthma. , May 5 is World Pulmonary Hypertension ... a leader in the global PH community, will take part ... high blood pressure of the lungs. PH is an increase ...
(Date:4/27/2015)... (PRWEB) April 27, 2015 Ticket Down is ... in Philadelphia for his upcoming concert on Sunday, June ... will thrill his countless North American fans again in 2015 ... with his "Out There" tour. He will be performing ... able to listen to this legendary performer for the first ...
(Date:4/27/2015)... Doctors on Liens has been the ... for over twenty years. So when attorneys of personal injury ... in the Fresno area , Doctors on Liens responded with ... of medical specialists. With a medical group of chiropractors, ... Chiropractic is now helping more personal injury victims than ...
(Date:4/27/2015)... Douglas Fitzpatrick not only sells auto, life and ... helps secure homes for animals. On May 9, 2015 from ... booth at the 2015 Fetch A Friend Adopt-a-thon at the ... Ohio. , “I am very excited to be part ... pets from more than forty different rescues, shelters and animal ...
(Date:4/27/2015)... On May 15, Mount Soma Ashram ... campaign to raise awareness of the vision of Mount ... Somesvara Temple. Ironically, when many of these people moved ... thought they were leaving the social and technological world ... of meditation, service to a higher cause, deep introspection, ...
Breaking Medicine News(10 mins):Health News:Pulmonary Hypertension Association Marks World PH Day on May 5 with a Worldwide Lifesaving Social Media Blitz 2Health News:Pulmonary Hypertension Association Marks World PH Day on May 5 with a Worldwide Lifesaving Social Media Blitz 3Health News:Paul McCartney Presale Tickets at Wells Fargo Center in Philadelphia: Ticket Down Slashes Paul McCartney Ticket Prices in Philadelphia at the Wells Fargo Center 2Health News:Eminent Doctor Joins Forces with Doctors on Liens in Fresno 2Health News:Farmers Insurance Agent Douglas Fitzpatrick Ensures Pets Find Homes 2Health News:Mount Soma Monks Do Social Media 2
(Date:4/27/2015)... , April 27, 2015  Boston Scientific Corporation (NYSE: ... America Merrill Lynch 2015 Healthcare Conference on May 12 in ... Brennan , executive vice president and chief financial officer, and ... in a 30-minute question and answer session regarding the company ... A live webcast of the presentation and question and ...
(Date:4/27/2015)... and WASHINGTON , April 27, 2015 ... and SmartBrief recently partnered to deliver a daily newsletter ... the top news in the industry. The purpose of ... biotechnology manufacturers, GPOs, distributors and other specialty pharmacy stakeholders ... on April 27, 2015. "We are looking ...
(Date:4/27/2015)... , April 27, 2015 The ... estimated to grow to around $4,211.2 million by 2019, at ... Browse through the TOC of the North America ... of the in-depth analysis provided. It also provides a glimpse ... and is supported by various tables and figures. ...
Breaking Medicine Technology:Boston Scientific To Participate In The Bank Of America Merrill Lynch 2015 Healthcare Conference 2NASP and SmartBrief Partner on Specialty Pharmacy SmartBrief 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 2North America Ophthalmology Surgery Device Market is Expected to Reach $4,211.2 Million by 2019, at a CAGR of 5.0% From 2014 to 2019 3
Cached News: