HOME >> MEDICINE >> NEWS
Yale study shows way to re-stimulate brain cell growth: Results could boost understanding of Alzheimer's, other brain disorders

New Haven, Conn.--Yale scientists have discovered that the growth of brain cells, which normally ends in adolescence, can be re-stimulated in mature neurons with a molecular mechanism known as Notch signaling.

Because Notch signaling also may be involved in the progression of degenerative diseases like Alzheimer's, the results published in the October 22 issue of Science could help scientists find ways to treat, or even prevent, this and other brain disorders.

"Our results not only help in our understanding of brain development, but they also have considerable implications for designing new treatments for many neurological disorders," said Pasko Rakic, M.D., the study's principal investigator.

"One of the hallmarks of Alzheimer's disease is the alteration of brain cell processes that can lead to irreversible memory loss and cognitive abilities characteristic of the disorder," Rakic said. "While we are still trying to determine what role Notch signaling plays in Alzheimer's, the results of this study could open possibilities for treating and preventing these kinds of brain disorders."

As the brain develops, neurons grow rapidly by extending neurites--dendrites and axons--which make millions of connections from birth up until adolescence, when the connections in the cerebral cortex begin to stabilize. As stabilization occurs, long term memory is acquired, allowing people to remember things throughout their lives. This new study provides a clue to how the transition from growth to stability might occur.

"We have identified the signaling pathway involved in the switch from growth to stability, as well as the associated molecules that can turn the switch on and off," said Rakic, professor and chair of neurobiology at Yale Medical School.

The main element of the signaling pathway is the Notch receptor, which was first described in studies at Yale in the 1940s and was then cloned at Yale in the 1980s, but its role in adult brain cells has
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
18-Oct-1999


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
(Date:10/20/2014)... New York, NY (PRWEB) October 20, 2014 ... City based non-profit organization that helps New Yorkers ... lasting, positive changes toward health, housing, recovery and ... who have transformed the local community through their ... Managing Director, Marc Shapses , has been ...
(Date:10/20/2014)... hc1.com today announced the launch of ... enables healthcare organizations of all sizes to immediately ... management (“CRM”) solution. , Designed from the ground ... healthcare industry, the hc1 Healthcare Relationship Cloud™ personalizes ... combining healthcare CRM, HIPAA-compliant collaboration, and real-time analytics ...
(Date:10/20/2014)... WA (PRWEB) October 20, 2014 My ... workflow management software application. The new module enables ... patients receive full life-cycle quality care. , This application ... others within their practice, attach a to-do item to ... fit, and even set up reoccurring reminders for follow-ups. ...
(Date:10/20/2014)... October 20, 2014 Myoderm ... as Assistant Director of their CentralSource ... managing the innovative turnkey drug sourcing, distribution, and ... brings over 12 years of industry experience, in ... at the peak of their international success to ...
(Date:10/20/2014)... Fort Collins, CO (PRWEB) October 20, 2014 ... platform, dGH assays are the only imaging assays ... data in a single test.  With these three ... in their ability to detect the widest range ... chromosomal translocations—mutations usually missed by other genomic tools, ...
Breaking Medicine News(10 mins):Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 2Health News:Savills Studley's Marc Shapses To Be Honored as 2014 "Positive Changemaker" by ASCNYC 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:KromaTiD Launches Genome Screening and Discovery Services 2Health News:KromaTiD Launches Genome Screening and Discovery Services 3
(Date:10/17/2014)... 2014  Training market researchers to spot and ... in today,s highly competitive global marketplace. As resources ... effectively and efficiently produce high performing analysts, regardless ... Effective training programs can help these ... internal clients by developing analysts who can drive ...
(Date:10/17/2014)... -- Research and Markets  has announced the ... of China Dialysis Market, 2014-2018" report to ... 2013 version, this update Report provides detailed analysis ... the relevant effect in recent three years, and ... it analyzes Chinese private-owned hemodialysis services. In the ...
(Date:10/17/2014)... BALTIMORE, Md. , Oct. 17, 2014 /PRNewswire-USNewswire/ ... Center for Medical Technology Policy: The ... from the FDA, public and private payers, medical ... representatives, clinicians, and other experts January 12, 2015 ... effectiveness and value of weight loss treatments.  Participants ...
Breaking Medicine Technology:Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
Cached News: