HOME >> MEDICINE >> NEWS
Yerkes researchers discover combination of drug therapies reduces cocaine use in primates

ATLANTA -- Researchers at the Yerkes National Primate Research Center of Emory University are the first to demonstrate a combination of drug therapies targeting the region of the brain that controls drug abuse and addiction significantly reduces cocaine use in nonhuman primates. These findings, which appear in the June issue of the Journal of Pharmacology and Experimental Therapeutics, have implications for developing treatments for cocaine addiction in humans.

Led by Leonard Howell, PhD, an associate professor in Yerkes' Neuroscience Division, the Yerkes researchers observed the innovative combination of dopamine transporter (DAT) inhibition and serotonin transporter (SERT) inhibition was effective in limiting cocaine use in rhesus macaques who are trained to self-administer cocaine. "It appears DAT inhibition serves to substitute for cocaine, while SERT inhibition may limit the abuse potential of the medication," said Howell. "Our results, therefore, showing a combination of DAT and SERT inhibition were more effective than either alone are very promising."

This first-time finding was the promising end result of a several-step process. Howell and his colleagues began by administering a pretreatment of DAT inhibitors to confirm their effectiveness in reducing drug use. DAT inhibitors have long been used in addiction studies because they elicit reinforcing properties in the brain similar to those experienced as a result of taking cocaine.

The research team then substituted the DAT inhibitors for cocaine in order to determine their effectiveness in maintaining the use of the medications. Finally, Howell and the team administered a pretreatment with combined DAT inhibition and SERT inhibition, which is known to block the chemical effects of cocaine in the brain and reduce addictive properties, to determine if cocaine use was further reduced. "Pretreatments with the combination therapy were very effective in eliminating cocaine use. Moreove
'"/>

Contact: Kelly Thompson
kthomp8@emory.edu
404-727-9254
Emory University Health Sciences Center
24-May-2004


Page: 1 2

Related medicine news :

1. Yerkes researchers discover natural brain chemical reduces effects of cocaine
2. Yerkes researchers discover natural brain chemical reduces effects of cocaine
3. Indiana University researchers closer to helping hearing-impaired using stem cells
4. Protein that helps skin cancer spread identified by Stanford researchers
5. US life expectancy about to decline, researchers say
6. Gene for age-related macular degeneration discovered by Yale researchers
7. Dartmouth researchers find where musical memories are stored in the brain
8. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
9. US cancer researchers launch first American-Israeli cancer conference
10. USC dental researchers develop first test for predicting cavities in children
11. Young blood revives aging muscles, Stanford researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/7/2020)... ... 07, 2020 , ... Dr. Louis M. DeJoseph is proud to ... scalp health. It is now possible to receive Keravive treatments from HydraFacial at the ... Dr. DeJoseph is able to provide clients with the best services to help them ...
(Date:7/4/2020)... ... July 03, 2020 , ... ... impairment, has announced the Best Memory Care Facilities in Charleston, South Carolina. The ... features and amenities. , According to the Alzheimer’s Association , 5.6 ...
(Date:7/2/2020)... ... July 02, 2020 , ... The Coronavirus (COVID-19) pandemic resulted ... In conjunction with the American Dental Association and Centers for Disease Control and ... , Due to safety concerns, the announcement sparked hesitancy among some hygienists, who ...
(Date:7/1/2020)... STATION, Texas (PRWEB) , ... July 01, 2020 ... ... solutions, announced today that it has been selected by Codiak BioSciences to support ... The PODs will provide the cleanroom infrastructure for the drug substance and product ...
(Date:6/28/2020)... ... 26, 2020 , ... The Coronavirus pandemic created shortages in ... supplier of top-quality masks, sanitizers and thermometers, Trusted PPE is a woman and ... observed, “All of our masks are manufactured to medical standards in FDA-certified factories, ...
Breaking Medicine News(10 mins):
(Date:7/2/2020)... SPRINGS, Miss. (PRWEB) , ... July 02, 2020 ... ... Springs, Mississippi-based wholesale pharmaceutical distributor, is pleased to announce its donation of more ... and the Michigan Department of Health and Human Services. As extreme medical shortages ...
(Date:7/1/2020)... ... July 01, 2020 , ... Stratodesk today announced ... is available on NComputing devices. Thanks to fantastic new growth and stellar adoption ... a new partnership that will make the full Stratodesk NoTouch OS branded image ...
(Date:6/25/2020)... ... 25, 2020 , ... R3 Medical Training announced today it is now enrolling ... locations. The first course is August 6-7, 2020 in San Diego and the second ... a Virtual Live Stream option. , The two day agenda for each course is ...
Breaking Medicine Technology:
Cached News: