Young breast cancer patients who chose lumpectomies need indefinite...( imilar between the two groups during th...),Health

imilar between the two groups during the first five years 57 in the conservation group and 53 in the mastectomy group. But, the mean age of patients in the conservation group who had local recurrence after 5-10 years was 46 and after 10 years it was 44. The only patient who had a local recurrence in the mastectomy group after five years was aged 59.

"We found a similar result in the database patients. Late breast recurrence was more frequent in the conservation group and the effect was even greater among patients who were under 40 when they were diagnosed. The whole difference in local recurrence between those who had conserving surgery and those who had mastectomies occurred after 10-15 years. Fifteen years after diagnosis, for those aged over 61 the incidence of local recurrence and contralateral breast cancer was 12% in both conservation and mastectomy groups. For 51 to 60 year-olds it was 12% in the conservation group and 5% in the mastectomy group. For 41 to 50-year olds it was 13% in the conservation group and 7% in the mastectomy group and for women up to 40 it was 36% in the conservation group and 12% in the mastectomy group.

"All these results were observed in patients who did not receive adjuvant treatment with tamoxifen, an anti-oestrogen that has been shown to have a beneficial effect on local control for patients with hormone-responsive tumours".

Dr Arriagada is a consultant radiation oncologist at the Instituto de Radiomedicina in Santiago, Chile, but worked for 25 years at the Institut Gustave-Roussy and spends long periods undertaking clinical research there as an invited professor. He said: "Our results confirm that a young age at diagnosis is a strong prognostic factor for local recurrence in breast conservation patients and not in patients treated by mastectomy.

"If these results are corroborated, younger patients should be informed of the higher risk of local recurrence and the need for indefinite follow up if th
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Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-153-677-2181
European Society for Medical Oncology
2-Nov-2003

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