HOME >> MEDICINE >> NEWS
Young people prone to type 2 diabetes exhibit alterations in mitochondrial activity

Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease.

They demonstrated a potential mechanism for the accumulation of fat in muscle cells of young, lean, insulin-resistant children of parents with type 2 diabetes by comparing them with insulin-sensitive control subjects matched for age, weight, height and activity.

"There is a strong relationship between lipid content in the muscle and insulin resistance in skeletal muscle," said principal investigator Gerald I. Shulman, M.D., professor of internal medicine and cellular & molecular physiology at Yale School of Medicine. "Insulin resistance is the best predictor for whether someone will eventually develop type 2 diabetes."

Using proton magnetic resonance spectroscopy (MRS), a safe, noninvasive method that does not involve any ionizing radiation, researchers found that insulin resistance in muscle of the diabetic offspring was accompanied by an increase in muscle cell lipid content.

Shulman, an investigator at the Howard Hughes Medical Institute, led his group to distinguish whether the increase in muscle cell triglycerides was the result of increased delivery of fatty acids to muscle cells from the fat stored in "fat cells" (adipocytes), or the result of a decreased rate of fat oxidation by the mitochondria in the muscle cells. They measured rates of fatty acid release from adipocytes and found no differences between the two groups. In contrast, using phosphorus MRS they found a 30 percent reduction in the rate of mitochondrial energy production in the muscle of insulin resistant subjects compared to the control group.

"These data support the hypothesis that insulin resistance in young, lean, healthy insulin resistant offspring of patients with type 2 diabetes may be due to an inherited defe
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
16-Feb-2004


Page: 1 2

Related medicine news :

1. 2005 Young Investigator Award
2. Study: Young adults can be motivated to eat fruits, veggies
3. Young blood revives aging muscles, Stanford researchers find
4. Young people face increasing risk of suicide in Scotland
5. Younger children in the child welfare system could benefit from specialty mental health services
6. Younger men lead surge in Viagra use, study reveals
7. Young breast cancer survivors suffer more long-term after effects
8. 2004 Young Investigator Award to Fleming
9. Young men with conduct disorders are more likely to carry guns
10. Young adult fitness protects heart health in middle age
11. Young breast cancer patients who chose lumpectomies need indefinite follow-up

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2020)... VANCOUVER, Wash. (PRWEB) , ... January 10, 2020 , ... ... today announced their partnership in a new online community coming in February 2020, LEAD ... in the Health and Wellbeing Village. , The vision of LEAD WELL with WOMEN ...
(Date:1/10/2020)... ... 2020 , ... SMG3Rx, a clinical mobility platform powered by ... (Healthcare Information and Management Systems Society) Global Conference & Exhibition taking place on ... event of the year, where professionals throughout the global health ecosystem connect for ...
(Date:1/8/2020)... ... 2020 , ... Pyxa Solutions, a leading provider of consulting, ... is rebranding as Red Nucleus R&D, a division of Red Nucleus. Red Nucleus ... industry. , The addition of Red Nucleus R&D under the Red Nucleus ...
(Date:1/8/2020)... ... January 09, 2020 , ... Real ... Webinar, Thursday, Jan. 23, 2020 • 1:30-3:00 p.m. EST, https://www.centerwatch.com/rweanddata ... (RWD) to generate evidence and identify gaps and challenges when conducting trials? The ...
(Date:1/7/2020)... Texas (PRWEB) , ... January 07, 2020 , ... ... today unveiled another facility expansion, adding to the company’s 200,000 sq. ft. manufacturing ... 25,000 sq. ft. of manufacturing space dedicated to POD architectural, mechanical, electrical and ...
Breaking Medicine News(10 mins):
(Date:1/22/2020)... ... January 22, 2020 , ... Clairvoyant Networks, ... Care GPS remote monitoring and communications technology was selected for demonstration in the ... showcases the latest technology and services for consumers and businesses needing solutions that ...
(Date:1/12/2020)... ... January 10, 2020 , ... ... has been selected to present at next week’s Biotech Showcase. Cytonus is ... with its proprietary Cargocyte™ next generation Adoptive Cellular Therapy (ACT) technologies which ...
(Date:1/10/2020)... ... January 10, 2020 , ... Reach ... Counselor Association, will celebrate high school counselors and award the first annual Excellence ... National Championship weekend and Extra Yard for Teachers Summit celebration on Saturday, January ...
Breaking Medicine Technology:
Cached News: