HOME >> MEDICINE >> NEWS
Young people prone to type 2 diabetes exhibit alterations in mitochondrial activity

Researchers at Yale have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease.

They demonstrated a potential mechanism for the accumulation of fat in muscle cells of young, lean, insulin-resistant children of parents with type 2 diabetes by comparing them with insulin-sensitive control subjects matched for age, weight, height and activity.

"There is a strong relationship between lipid content in the muscle and insulin resistance in skeletal muscle," said principal investigator Gerald I. Shulman, M.D., professor of internal medicine and cellular & molecular physiology at Yale School of Medicine. "Insulin resistance is the best predictor for whether someone will eventually develop type 2 diabetes."

Using proton magnetic resonance spectroscopy (MRS), a safe, noninvasive method that does not involve any ionizing radiation, researchers found that insulin resistance in muscle of the diabetic offspring was accompanied by an increase in muscle cell lipid content.

Shulman, an investigator at the Howard Hughes Medical Institute, led his group to distinguish whether the increase in muscle cell triglycerides was the result of increased delivery of fatty acids to muscle cells from the fat stored in "fat cells" (adipocytes), or the result of a decreased rate of fat oxidation by the mitochondria in the muscle cells. They measured rates of fatty acid release from adipocytes and found no differences between the two groups. In contrast, using phosphorus MRS they found a 30 percent reduction in the rate of mitochondrial energy production in the muscle of insulin resistant subjects compared to the control group.

"These data support the hypothesis that insulin resistance in young, lean, healthy insulin resistant offspring of patients with type 2 diabetes may be due to an inherited defe
'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
16-Feb-2004


Page: 1 2

Related medicine news :

1. 2005 Young Investigator Award
2. Study: Young adults can be motivated to eat fruits, veggies
3. Young blood revives aging muscles, Stanford researchers find
4. Young people face increasing risk of suicide in Scotland
5. Younger children in the child welfare system could benefit from specialty mental health services
6. Younger men lead surge in Viagra use, study reveals
7. Young breast cancer survivors suffer more long-term after effects
8. 2004 Young Investigator Award to Fleming
9. Young men with conduct disorders are more likely to carry guns
10. Young adult fitness protects heart health in middle age
11. Young breast cancer patients who chose lumpectomies need indefinite follow-up

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/15/2018)... , ... September 14, 2018 , ... ... among other funding, full FY 2019 appropriations for Labor, Health and Human Services ... for the evidence-based Teen Pregnancy Prevention (TPP) Program, and $286.5 million for the ...
(Date:9/12/2018)... ... , ... Today, Sterling , a rope and life-safety equipment company, announced ... climb of the Lotus Flower Tower in Canada’s Cirque of the Unclimbables. Although Jim ... the duo decided to persevere and with some assistance from rigger Pat Goodman and ...
(Date:9/7/2018)... ... 07, 2018 , ... Start your engines and race to the new ... to choose. Pedal power is the name of the game here – whether it’s ... on the miniature Indianapolis Motor Speedway oval. , The timing couldn’t be better with ...
(Date:9/2/2018)... ... September 02, 2018 , ... Eaton Hotel in Washington, DC ... itself, which opened this week, inspires creativity and innovation among its guests, whether ... Hotel DC currently features 209 hotel rooms, a wellness center, a radio station, ...
(Date:8/31/2018)... ... August 31, 2018 , ... ... list. , This list includes independent community hospitals as well as facilities affiliated ... for small communities outside of large cities. The hospitals continue to grow in ...
Breaking Medicine News(10 mins):
(Date:9/7/2018)... Texas (PRWEB) , ... September 07, 2018 , ... Yisrayl Hawkins, Pastor and Overseer at ... reveals the True Name of the Creator and says the proof is undeniable. , Yisrayl ... used in place of the Creator’s Name. Yisrayl shows there is great meaning in the ...
(Date:9/1/2018)... ... September 01, 2018 , ... Two Frogs Healing Center, a natural treatment ... the Getting Rid of Lyme Disease Issues with Liposomes Evening Lecture on Wednesday September ... Lyme Disease is the number one vector borne illness in the US and in ...
(Date:8/31/2018)... ... August 31, 2018 , ... The Centers for Disease ... years of expertise in delivering comprehensive wellness engagement solutions, has been selected as ... Health will receive a $40,000 grand prize for its winning proposal, Closing the ...
Breaking Medicine Technology:
Cached News: