HOME >> MEDICINE >> NEWS
ZETIA(R) co-administered with fenofibrate provided complementary lipid lowering efficacy

NEW ORLEANS, November 8, 2004 Results from a new study showed that coadministration of ZETIA (ezetimibe) and fenofibrate significantly reduced LDL ("bad") cholesterol (LDL-C), non-high density lipoprotein cholesterol (non-HDL-C) and apo B in patients with mixed hyperlipidemia and high LDL cholesterol when compared to fenofibrate alone. The study, presented today at the 2004 American Heart Association Scientific Sessions, also showed that significant increases in HDL cholesterol and decreases in trigycerides (TG) similar to those seen with fenofibrate alone were seen in patients on ZETIA co-administered with fenofibrate. The treatment with ZETIA and fenofibrate for 12 weeks was also well-tolerated with a safety profile comparable to fenofibrate monotherapy. The label for ZETIA indicates that the safety and effectiveness of ZETIA with fibrates have not been established, therefore co-administration with fibrates is not recommended.

"This is the first large study to indicate that co-administration of ZETIA and fenofibrate significantly lowers LDL cholesterol and non-HDL cholesterol more than fenofibrate alone in a mixed hyperlipidemia population. This study revealed that when diet changes alone were not sufficient in mixed hyperlipidemia, the co-administration of ezetimibe and fenofibrate significantly lowered LDL cholesterol, compared to fenofibrate alone. ZETIA co-administered with fenofibrate also improved HDL cholesterol and triglyceride levels similar to fenofibrate alone," said Mason Wright Freeman, M.D., chief, Lipid Metabolism Unit, Massachusetts General Hospital. "Mixed hyperlipidemia is a metabolic disorder characterized by elevated LDL cholesterol, non HDL-C and TG and reduced levels of HDL cholesterol. Co-administration of ZETIA and fenofibrate is not indicated for use in the label for ZETIA, however further studies in these populations are certainly warranted to confirm these findings."

ZETIA co-administered with fenofibrate provi
'"/>

Contact: Skip Irvine, Merck & Co., Inc.
267-305-5397
Porter Novelli
8-Nov-2004


Page: 1 2 3 4

Related medicine news :

1. Asthma symptoms reduced among children whose schools provided asthma medication
2. Most child care is provided by informal providers, study finds
3. Third of European cancer patients use complementary and alternative therapies
4. Pediatricians wary about recommending complementary therapies
5. More than one-third of US adults use complementary and alternative medicine
6. Survey provides comprehensive look at use of complementary and alternative medicine in US
7. Seal of approval scheme needed for complementary and alternative websites
8. Many children with autism may receive complementary or alternative treatments
9. U-M Medical School complementary and alternative medicine curriculum an interdisciplinary model
10. Georgetown receives $1.7 million NIH grant to add complementary and alternative medicine to curriculum
11. NIH grant keeps University of Maryland on the cutting edge of complementary and alternative medicine

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... ... ... Feeding Matters , the first organization in the world dedicated to advancing the ... that the U.S. Centers for Disease Control and Prevention (CDC) has officially approved PFD ... U.S. International Classification of Diseases (ICD ) on October 1, 2021. ...
(Date:9/1/2020)... ... 2020 , ... Dr. Kiran Gill is a Board Certified ... face, breast, and body. In 2018, she founded Aesthetics in Plastic Surgery by ... practice in Southwest Florida. Dr. Gill and her team offer surgical and non-surgical ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... announced the 10th Anniversary of Blood Cancer Awareness Month (BCAM) and its international ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean ... face masks to medical first responders across the United States. Since the start ... personal protective equipment (PPE) medical centers , hospitals , firefighters ...
(Date:8/31/2020)... ... 2020 , ... Genesis Chiropractic Software and Billing Network ... of its integrated, HIPAA compliant, telehealth solution, available to US-based clients immediately. With ... seconds. , According to the U.S. Department of Health & Human Services, ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... SANTA CLARA, Calif. (PRWEB) , ... September 01, ... ... diagnostics, and analytical laboratory technologies, will host the Agilent Science and Technology ... , During this two-day symposium, Agilent will open a suite of Live webinars ...
(Date:9/1/2020)... ... ... Breast and ovarian cancers are common diseases that affect many women. According ... women per year) and 10% of ovarian cancers (about 2,000 women per year) result ... in the Women’s Excellence Genetic Testing Program. , Dr. Jonathan Zaidan, MD, FACOG, President ...
(Date:8/31/2020)... ... 2020 , ... Continuing on its rapid national expansion - ... deodorization provider - is proud to announce it has opened doors in Phoenix, ... residents throughout the area. , Germinator provides a 100% safe and non-toxic sanitizing ...
Breaking Medicine Technology:
Cached News: