HOME >> MEDICINE >> NEWS
Zengen's new study reviews novel approach to control inflammation using melanocortin receptors

WOODLAND HILLS, Calif. (March 3, 2004) Zengen, Inc. announced today that its researchers have discovered that activation of melanocortin receptors (MCR) subtypes MC1R and MC3R could be a novel strategy to control inflammatory disorders.

The findings, "Targeting Melanocortin Receptors as a Novel Strategy to Control Inflammation," appear in the March 2004 issue of Pharmacological Reviews, a publication of the American Society for Pharmacology and Experimental Therapeutics (ASPET).

"MCR activation causes a collective reduction of the major molecules involved in the inflammatory process," said Anna Catania, M.D., professor of endocrinology, School of Internal Medicine, University of Milan and lead author of the study. "This discovery is significant because it shows that treatment with melanocortin peptides doesn't abolish the inflammatory response but instead modulates it. An advantage of melanocortins in the treatment of inflammation is that their influences are broad and are not restricted to a specific mediator or chemical pathway."

Recognition and cloning of five melanocortin receptors has greatly improved understanding of peptide-target cell interactions. Preclinical investigations indicate that activation of certain MCR subtypes, primarily MC1R and MC3R, could be useful in treatment of localized and systemic inflammatory disorders. These include: organ transplantation, chronic inflammatory diseases, acute inflammation, inflammation within the brain and neurogenerative disorders, peripheral neuropathies, systemic host reactions, ischemia and reperfusion injury and infections.

"The study results also indicate that certain melanocortin peptides have antimicrobial effects," said James Lipton, Ph.D., chief scientific officer and director of Zengen and study author. "Unlike corticosteroids, melanocortins do not reduce microbial killing activity, but enhance it. We are encouraged by these findings and will continue our res
'"/>


3-Mar-2004


Page: 1 2

Related medicine news :

1. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
2. UMaine study looks at infants and chronic nighttime crying
3. Chronic pain treatments more effective when taken together, new study shows
4. UNC study: Most N.C. family practitioners engage in unrecognized community service
5. New study in Nature demonstrates protection against cell death during heart attack
6. UCSF study offers insight into human circadian rhythms
7. International breast cancer prevention study launches in the United States and Canada
8. UW study shows blacks and Latinos are more satisfied with physicians of the same race
9. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study
10. Advertising by academic medical centers may risk eroding public trust, says study
11. Fat may promote inflammation, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... NEW YORK (PRWEB) , ... August 31, 2020 ... ... the nation’s largest non-profit organization devoted exclusively to funding innovative lymphoma research and ... and patient services – today announced the 10th Anniversary of Blood Cancer Awareness ...
(Date:8/31/2020)... N.J. (PRWEB) , ... August 31, 2020 , ... ... leading cloud-based business management solution for chiropractors, announced today the launch of its ... healthcare professionals can start running their virtual practice in under 90 seconds. ...
(Date:8/31/2020)... MAUI, Hawaii (PRWEB) , ... August 31, 2020 , ... A Cure for Covid-19 “PTS” ... most people on the planet are in a state of panic, experiencing deep anxiety, immense ... , Right now, a solution is timely when most people on the planet are experiencing ...
(Date:8/29/2020)... ... ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, he ... become melancholic, however, he put together a final lecture in Carnegie Hall in which ... negative situation and turned it into something that inspired millions of people worldwide. This ...
(Date:8/28/2020)... ... August 28, 2020 , ... With in-person gluten-free events ... continue helping the specialty-diet community connect with great, gluten-free brands. At the ... giveaways, chat with brands & watch over 50 educational classes... all online from ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... ... Cosmetics and Laser Surgery at the University of Rochester Medical Center, in Upstate ... SkinCare Physicians in Boston, with clinical faculty from the Harvard and Yale Departments ...
(Date:8/31/2020)... AVIV, Israel (PRWEB) , ... August 31, 2020 ... ... to specialize in wellness-related technologies, today announced that they have invested $400,000 in ... competition that ran in collaboration with the Global Wellness Institute (GWI). , ...
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Mark Surrey ... endoscopic surgeon and serves as a clinical professor in the Department of OBGYN at ... American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical Director of ...
Breaking Medicine Technology:
Cached News: