HOME >> MEDICINE >> NEWS
3-D forms link antibiotic resistance and brain disease

The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. The story takes a twist as key differences among the structures of its main molecular characters disappear and reappear as they are assembled in the cell.

A report on this study appears in the August 16 issue of the journal Structure.

The story is based on a study of the 3-D structure of an enzyme called pantothenate kinase, which triggers the first step in the production coenzyme A (CoA), a molecule that is indispensable to all forms of life. Enzymes are proteins that speed up biochemical reactions. CoA plays a pivotal role in the cells' ability to extract energy from fatty acids and carbohydrates; bacteria need CoA to make their cell walls. The job of pantothenate kinase is to grab a molecule of pantothenic acid (vitamin B-5) and another molecule that contains a chemical group called "phosphate." The enzyme then removes the phosphate group from that molecule and sticks it onto pantothenic acid.

In humans, certain mutations in this enzyme block its ability to put the phosphate group onto pantothenic acid. That diminishes the production of CoA by this route and causes the neurodegenerative disease called pantothenate kinase associated neurodegeneration (PKAN), according to Suzanne Jackowski, Ph.D., a member of the St. Jude Department of Infectious Diseases and a co-author of the paper. "We also know that certain antibiotics called pantothenamides work by impersonating vitamin B-5 and slipping into the enzyme," Jackowski said. "This blocks the bacteria's ability to produce fatty acids." The researchers already knew that different types of bacteria build their own versions of the enzyme pantothenate kinase, which are called Types I, II and III. For example, bacteria c
'"/>

Contact: Bonnie Kourvelas
bonnie.kourvelas@stjude.org
901-495-4815
St. Jude Children's Research Hospital
17-Aug-2006


Page: 1 2 3 4

Related medicine news :

1. UQ researchers discover some of the oldest forms of life
2. New reforms could cut the number of unexplained infant deaths
3. UPMC performs first beating heart transplant procedure in the US
4. Satellite images aid implementation of agricultural reforms
5. Genetic pathways to curable and incurable forms of pancreatic cancer identified
6. Comprehensive reforms to move toward patient-centered care released by ACP
7. Reforms to gun dealer sales practices reduce supply of new guns to criminals
8. Mexicos health-system reforms showing encouraging results
9. All forms of tobacco exposure are bad for the heart
10. Low literacy increases risk of death and misunderstanding of medical consent forms
11. Cancer researchers confirm brain tumor genetic subtype informs treatment, predicts outcome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: forms link antibiotic resistance and brain disease

(Date:7/3/2015)... ... ... The Celebrity Dresses is currently running a promotion through July 30th. Anyone ... the opportunity to get 10% discount on orders that are over $100. , The ... use coupon codes or remember redemption codes. , There is a low price ...
(Date:7/2/2015)... ... July 02, 2015 , ... Following the recent report by ... obese Americans outnumber merely overweight Americans, Samir Becic emphatically declared a war on obesity ... society right now," Becic said. "We must understand the magnitude of this discovery. For ...
(Date:7/2/2015)... ... ... summer in full swing, Americans are flocking to Canada’s many lakes to reel in their ... the world, and it’s easy to understand why. From the Pacific Northwest Coast of British ... fishing is a huge industry, and Americans make up the vast majority of anglers from ...
(Date:7/2/2015)... ... July 02, 2015 , ... Get ready to hit ... SOCKS. Since the socks were first introduced, they have rapidly been gaining attention ... inspired four new, fun shades including: blue, lime, pink and red. , ...
(Date:7/2/2015)... ... July 02, 2015 , ... ActiveBunch.com recently launched as a social ... Built to function as a lifestyle community, Active Bunch allows users to connect with ... meet, and participate in discussions or group events. , The spokesperson for Active ...
Breaking Medicine News(10 mins):Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2Health News:ActiveBunch.com Launches as a Social Community for People with Active Lifestyles 2
(Date:7/2/2015)... , July 2, 2015 /PRNewswire/ - ESSA Pharma Inc. ... common shares have been approved for listing and trading on ... ESSA will begin trading on NASDAQ on July 9, ... Venture Exchange under the symbol "EPI". As a ... NASDAQ, each of the Company,s outstanding special warrants issued on ...
(Date:7/2/2015)... NYACK, N.Y. , July 2, 2015  Before you ... plan ahead so you can stay safe and healthy. Take ... plants #summersafety. Infographic http://nyackhospital.org/summersafety Protect Your ... rays from the sun can increase your risk of skin ... the shade as much as possible, especially during midday hours. ...
(Date:7/2/2015)... , June 26, 2015 Research ... "Vitamin D Market by Analog, Application, End-User & by ... to their offering. This market is projected to ... vitamin D in different applications and rising opportunities in countries ... , Italy , and ...
Breaking Medicine Technology:ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 2ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 3ESSA Pharma Inc. to Commence Trading on the NASDAQ Capital Market 4First Aid Summer Survival Tips from Nyack Hospital 2First Aid Summer Survival Tips from Nyack Hospital 3Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 2Vitamin D Market by Analog, Application, End-User & by Region - Global Trends & Forecast to 2020: Increasing Recommendation By Doctors & Associations 3
Cached News: