HOME >> MEDICINE >> NEWS
3-D forms link antibiotic resistance and brain disease

The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. The story takes a twist as key differences among the structures of its main molecular characters disappear and reappear as they are assembled in the cell.

A report on this study appears in the August 16 issue of the journal Structure.

The story is based on a study of the 3-D structure of an enzyme called pantothenate kinase, which triggers the first step in the production coenzyme A (CoA), a molecule that is indispensable to all forms of life. Enzymes are proteins that speed up biochemical reactions. CoA plays a pivotal role in the cells' ability to extract energy from fatty acids and carbohydrates; bacteria need CoA to make their cell walls. The job of pantothenate kinase is to grab a molecule of pantothenic acid (vitamin B-5) and another molecule that contains a chemical group called "phosphate." The enzyme then removes the phosphate group from that molecule and sticks it onto pantothenic acid.

In humans, certain mutations in this enzyme block its ability to put the phosphate group onto pantothenic acid. That diminishes the production of CoA by this route and causes the neurodegenerative disease called pantothenate kinase associated neurodegeneration (PKAN), according to Suzanne Jackowski, Ph.D., a member of the St. Jude Department of Infectious Diseases and a co-author of the paper. "We also know that certain antibiotics called pantothenamides work by impersonating vitamin B-5 and slipping into the enzyme," Jackowski said. "This blocks the bacteria's ability to produce fatty acids." The researchers already knew that different types of bacteria build their own versions of the enzyme pantothenate kinase, which are called Types I, II and III. For example, bacteria c
'"/>

Contact: Bonnie Kourvelas
bonnie.kourvelas@stjude.org
901-495-4815
St. Jude Children's Research Hospital
17-Aug-2006


Page: 1 2 3 4

Related medicine news :

1. UQ researchers discover some of the oldest forms of life
2. New reforms could cut the number of unexplained infant deaths
3. UPMC performs first beating heart transplant procedure in the US
4. Satellite images aid implementation of agricultural reforms
5. Genetic pathways to curable and incurable forms of pancreatic cancer identified
6. Comprehensive reforms to move toward patient-centered care released by ACP
7. Reforms to gun dealer sales practices reduce supply of new guns to criminals
8. Mexicos health-system reforms showing encouraging results
9. All forms of tobacco exposure are bad for the heart
10. Low literacy increases risk of death and misunderstanding of medical consent forms
11. Cancer researchers confirm brain tumor genetic subtype informs treatment, predicts outcome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: forms link antibiotic resistance and brain disease

(Date:7/29/2015)... ... July 29, 2015 , ... ... delivery model, application, end user and region. Factors such as the rising pressure ... benefits of analytics, and increase in venture capital investments are driving market growth. ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... shops are anticipating testing regulations imposed by the FDA for nicotine laced liquid ... use of electronic cigarettes have raised considerably. E-Cigarettes are particularly troublesome to addiction ...
(Date:7/29/2015)... , ... July 29, 2015 , ... Orthopedic surgeons at ... offer the Rotation Medical Rotator Cuff System, a new implant to treat a common ... designed to foster natural regeneration of additional tendon tissue, which could allow for faster ...
(Date:7/29/2015)... York, NY (PRWEB) , ... July 29, 2015 , ... ... were approved by USCIS over the past month! I-829 approvals have been granted to ... in Los Angeles, the Kimpton Lafayette Hotel project in Philadelphia, and the Valley ...
(Date:7/29/2015)... , ... July 29, 2015 , ... It is unique ... “This is a tremendous model of care. One that is very hands on and ... executive director of Monarch Landing. “She’s bringing great passion and energy, as well as ...
Breaking Medicine News(10 mins):Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 2Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 3Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 4Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 5Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 2Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 3Health News:Lourdes Orthopedics First in NJ to Offer Bioinductive Implant for Rotator Cuff Repair 2Health News:Lourdes Orthopedics First in NJ to Offer Bioinductive Implant for Rotator Cuff Repair 3Health News:More Than 60 New I-829 Approvals in Less Than 30 days for CanAm 2Health News:More Than 60 New I-829 Approvals in Less Than 30 days for CanAm 3Health News:New Medical Director Readies To Take Reins at Monarch Landing 2Health News:New Medical Director Readies To Take Reins at Monarch Landing 3
(Date:7/29/2015)... July 29, 2015 According to ... " Active Pharmaceutical Ingredients (API) Market - Global Industry ... 2020 " the global active pharmaceutical ingredients market was ... anticipated to reach USD 185.9 billion by 2020, expanding ... from 2014 to 2020. Full Research Report ...
(Date:7/29/2015)... -- Medical Care Alert, a leading national provider of personal ... its new HOME & AWAY ELITE mobile GPS ... on the hip, the small two-ounce pendant can summon ... using the AT&T Wireless network. The HOME ... and automatic fall detection medical alert systems. ...
(Date:7/29/2015)... CHENNAI, India , July 29, 2015 TAKE ... its foray into the big data market for the Life ... new US-based subsidiary, with an initial investment of 3 ... billion healthcare and life sciences market (according to projections by ... integration and advanced analytics. ...
Breaking Medicine Technology:Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 2Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 3Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 4Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 5New Medical Care Alert Pendant Combines GPS, Cellular Voice, and Automatic Fall Detection 2New Medical Care Alert Pendant Combines GPS, Cellular Voice, and Automatic Fall Detection 3New Medical Care Alert Pendant Combines GPS, Cellular Voice, and Automatic Fall Detection 4TAKE Solutions Creates a New Subsidiary for Life Sciences Big Data in the US 2TAKE Solutions Creates a New Subsidiary for Life Sciences Big Data in the US 3
Cached News: