HOME >> MEDICINE >> NEWS
3-D forms link antibiotic resistance and brain disease

The story of what makes certain types of bacteria resistant to a specific antibiotic has a sub-plot that gives insight into the cause of a rare form of brain degeneration among children, according to investigators at St. Jude Children's Research Hospital. The story takes a twist as key differences among the structures of its main molecular characters disappear and reappear as they are assembled in the cell.

A report on this study appears in the August 16 issue of the journal Structure.

The story is based on a study of the 3-D structure of an enzyme called pantothenate kinase, which triggers the first step in the production coenzyme A (CoA), a molecule that is indispensable to all forms of life. Enzymes are proteins that speed up biochemical reactions. CoA plays a pivotal role in the cells' ability to extract energy from fatty acids and carbohydrates; bacteria need CoA to make their cell walls. The job of pantothenate kinase is to grab a molecule of pantothenic acid (vitamin B-5) and another molecule that contains a chemical group called "phosphate." The enzyme then removes the phosphate group from that molecule and sticks it onto pantothenic acid.

In humans, certain mutations in this enzyme block its ability to put the phosphate group onto pantothenic acid. That diminishes the production of CoA by this route and causes the neurodegenerative disease called pantothenate kinase associated neurodegeneration (PKAN), according to Suzanne Jackowski, Ph.D., a member of the St. Jude Department of Infectious Diseases and a co-author of the paper. "We also know that certain antibiotics called pantothenamides work by impersonating vitamin B-5 and slipping into the enzyme," Jackowski said. "This blocks the bacteria's ability to produce fatty acids." The researchers already knew that different types of bacteria build their own versions of the enzyme pantothenate kinase, which are called Types I, II and III. For example, bacteria c
'"/>

Contact: Bonnie Kourvelas
bonnie.kourvelas@stjude.org
901-495-4815
St. Jude Children's Research Hospital
17-Aug-2006


Page: 1 2 3 4

Related medicine news :

1. UQ researchers discover some of the oldest forms of life
2. New reforms could cut the number of unexplained infant deaths
3. UPMC performs first beating heart transplant procedure in the US
4. Satellite images aid implementation of agricultural reforms
5. Genetic pathways to curable and incurable forms of pancreatic cancer identified
6. Comprehensive reforms to move toward patient-centered care released by ACP
7. Reforms to gun dealer sales practices reduce supply of new guns to criminals
8. Mexicos health-system reforms showing encouraging results
9. All forms of tobacco exposure are bad for the heart
10. Low literacy increases risk of death and misunderstanding of medical consent forms
11. Cancer researchers confirm brain tumor genetic subtype informs treatment, predicts outcome

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/24/2017)... Estates, CA (PRWEB) , ... January 24, 2017 , ... ... at studies, work, athletics or even in relationships. Course offered by Dr. Carol ... is necessary due to limited seating and the many hands-on experiences. , ...
(Date:1/24/2017)... PA (PRWEB) , ... January 24, 2017 , ... His ... but the co-founder of the organization End Distracted Driving , Joel Feldman, has ... , Feldman's story was featured in one of the top newspapers in circulation in ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... The University ... has taken great care to design a program that provides teachers with the specific ... domestically. This online teaching certificate is ideal for post-baccalaureate students and HigherEducation.com is working ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... American Family ... Bedford, expanding access to high-quality health care for residents in the area. The Bedford ... location opened during the past four years by Dave Adams and Dr. Kristina Orio. ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Choosing Wisdom-Solomon’s ... finances, friendship, marriage, leadership, gossip, prostitution, adultery, anger, and common sense. , ... Judith Coats and Dr. David Coats. In September of 1983, they flew to ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... The Society for Non OR Intervention and Anesthesia ( ... Safety ( PPAHS ) are pleased to announce their ... for patients undergoing procedures outside of the Operating Room. ... Michael Wong JD, Executive Director of PPAHS have each ... Boards. SONORIA is an integrated group of ...
(Date:1/24/2017)... Md. , and GAITHERSBURG, Md. , ... XON ), a leader in the engineering and industrialization ... of the planet, today announced that it has entered into ... GNVC ), a clinical-stage company and pioneer in ... Intrexon intends to integrate and expand upon GenVec,s expertise in ...
(Date:1/24/2017)... , January 24, 2017 www.Financialbuzz.com ... growing industries in the United States ... in 2016. In addition, Proposition 64, the California Cannabis Legalization ... 42.87% against on November 8, 2016. This outcome means that ... use and to grow a certain amount of cannabis for ...
Breaking Medicine Technology:
Cached News: