HOME >> MEDICINE >> NEWS
A fundamentally new approach to improving cancer chemotherapy

A new strategy for getting anti-cancer drugs to kill cancer cells, without causing serious harm to normal cells in the body, is reported in the current [June] issue of ACS Chemical Biology, a monthly peer-reviewed journal of the American Chemical Society.

The approach, tested in laboratory experiments with several existing anti-cancer drugs, could offer substantial benefits for cancer patients, according to Jeffrey P. Krise, Ph.D. Krise led a group of pharmaceutical and medicinal chemists at the University of Kansas at Lawrence who did the research.

The new approach would allow anticancer drugs to accumulate in both normal and malignant cells. The drugs, however, would be tweaked by giving them "basic" chemical properties. In chemistry, "basic" means an alkaline substance like baking soda or laundry detergent, which has properties opposite those of acidic substances.

Normal cells simply isolate anti-cancer drugs with basic properties, greatly reducing the toxic effects. Cancer cells, in contrast, have an impaired ability to isolate basic substances, and get hit with a full blast of toxicity.

"It could allow cancer patients to tolerate higher and more effective doses of chemotherapy before normal cells are damaged to an extent that causes serious side effects and cessation of therapy," Krise said. "The approach is completely different from previous attempts that were designed to deliver drugs only to cancer cells and not normal cells."

"The results of our studies should lead to the development of rationally designed molecules that are more selective and produce fewer side effects," Krise explained. "Importantly, this technology can also be used to modify existing drugs and increase their selectivity."

Krise's report describes a number of existing anti-cancer drugs that have basic properties, and notes that the new findings may provide the first explanation of why these drugs are so effective.

"There is ob
'"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-4400
American Chemical Society
5-Jun-2006


Page: 1 2

Related medicine news :

1. Patient-centered approach can backfire
2. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. Rosiglitazone -- Seeking a balanced approach to avoid panic among patients
5. Treatment of kidney condition requires an individualized approach
6. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression
7. Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
8. Combined imaging approach may provide better identification of difficult-to-diagnose brain clots
9. AHA statement recommends doctors change approach
10. Penn addiction researcher presents talk on promising approaches in the treatment of drug addiction
11. New data supports a non-invasive approach to routine prenatal genetic testing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... A man who has struggled to quit smoking, a man who ... was determined to find solutions to his problems – and he did. Now Nabat, a ... ready to introduce his breakthrough inventions to the world and better people's lives. His own ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... metro area, has selected the latest beneficiary of their ongoing community enrichment program. ... preventing bullying in area schools. Donations are now being accepted at: http://www.angelsanddoves.com/donate.html ...
(Date:2/8/2016)... ... 2016 , ... Eating disorders and post-traumatic stress disorder (PTSD) ... men with eating disorders report a history of trauma, research suggests that it ... eating disorder. , At the 2016 iaedp Symposium, the workshop, “What Eating ...
(Date:2/8/2016)... ... February 08, 2016 , ... TopConsumerReviews.com recently awarded their ... removal products. , Moles are derived from a cluster of melanin when exposed to ... wrong places and create a lifetime of embarrassment. Historically, mole removal has ...
(Date:2/7/2016)... (PRWEB) , ... February 07, 2016 , ... ... prolapse with the latest techniques and the most minimally invasive approaches. , Women ... prolapse, particularly after menopause. Other risk factors include surgery to the pelvic floor, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 2016 In a historic vote among its members this weekend, ... medical cannabis cultivation facility and dispensary on tribal land near ... as a provider for patients in the state,s Medical Cannabis Program. ... a provider for patients in the state,s Medical Cannabis Program. ... the project and pursue designation from the State of New ...
(Date:2/8/2016)... BASEL , Switzerland and PALO ALTO, Calif. ... leader in biological and chemical manufacturing, and Kodiak Sciences ... for the treatment of retinal disease, announced today agreements ... the agreement, Lonza will manufacture material at multiple sites, ... --> --> Retinal ...
(Date:2/8/2016)... -- Aoxing Pharmaceutical Company, Inc. (NYSE MKT: AXN) today announced that ... 31, 2015, the Company achieved revenue of $8,195,839, a 27% ... in fiscal 2015. --> --> ... 2016 was $2,068,635, or $.03 per share, up 265% from ... the Q2 of fiscal year 2015. Gross margin for the ...
Breaking Medicine Technology:
Cached News: