HOME >> MEDICINE >> NEWS
A fundamentally new approach to improving cancer chemotherapy

A new strategy for getting anti-cancer drugs to kill cancer cells, without causing serious harm to normal cells in the body, is reported in the current [June] issue of ACS Chemical Biology, a monthly peer-reviewed journal of the American Chemical Society.

The approach, tested in laboratory experiments with several existing anti-cancer drugs, could offer substantial benefits for cancer patients, according to Jeffrey P. Krise, Ph.D. Krise led a group of pharmaceutical and medicinal chemists at the University of Kansas at Lawrence who did the research.

The new approach would allow anticancer drugs to accumulate in both normal and malignant cells. The drugs, however, would be tweaked by giving them "basic" chemical properties. In chemistry, "basic" means an alkaline substance like baking soda or laundry detergent, which has properties opposite those of acidic substances.

Normal cells simply isolate anti-cancer drugs with basic properties, greatly reducing the toxic effects. Cancer cells, in contrast, have an impaired ability to isolate basic substances, and get hit with a full blast of toxicity.

"It could allow cancer patients to tolerate higher and more effective doses of chemotherapy before normal cells are damaged to an extent that causes serious side effects and cessation of therapy," Krise said. "The approach is completely different from previous attempts that were designed to deliver drugs only to cancer cells and not normal cells."

"The results of our studies should lead to the development of rationally designed molecules that are more selective and produce fewer side effects," Krise explained. "Importantly, this technology can also be used to modify existing drugs and increase their selectivity."

Krise's report describes a number of existing anti-cancer drugs that have basic properties, and notes that the new findings may provide the first explanation of why these drugs are so effective.

"There is ob
'"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-4400
American Chemical Society
5-Jun-2006


Page: 1 2

Related medicine news :

1. Patient-centered approach can backfire
2. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. Rosiglitazone -- Seeking a balanced approach to avoid panic among patients
5. Treatment of kidney condition requires an individualized approach
6. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression
7. Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
8. Combined imaging approach may provide better identification of difficult-to-diagnose brain clots
9. AHA statement recommends doctors change approach
10. Penn addiction researcher presents talk on promising approaches in the treatment of drug addiction
11. New data supports a non-invasive approach to routine prenatal genetic testing

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: fundamentally new approach improving cancer chemotherapy

(Date:7/30/2015)... ... 30, 2015 , ... After conducting a nationwide executive search led by healthcare ... in Far Rockaway, N.Y., has hired Gerard (Jerry) Walsh as Chief Executive Officer. Walsh ... healthcare leadership experience, Walsh is an expert in organizational change, physician development, implementation of ...
(Date:7/30/2015)... ... 2015 , ... HEALTHCAREfirst , the leading provider of cloud-based software, services ... hosting a free webinar detailing the 2016 proposed rule from CMS for home health. ... President of Regulatory Affairs for the National Association for Home Care and Hospice (NAHC), ...
(Date:7/30/2015)... Orem, UT (PRWEB) , ... July 30, 2015 , ... When trying to gain weight, many people place a lot ... the amount of calories that need to be consumed. However, another key component to successful ... to gain weight. To assist with this, CB-1 Weight Gainer gives three tips on ...
(Date:7/30/2015)... ... July 30, 2015 , ... World ... women to ensure their children have the nutrition required to grow into healthy ... offering discount cards for many prescription pre-natal vitamins. , Folic Acid , Arguably ...
(Date:7/29/2015)... ... July 30, 2015 , ... Drs. Hamstead are very excited to announce ... therapy to the offerings in the clinic; massage therapy works very well alongside chiropractic ... Crystal Gaines has joined AlignLife of Simpsonville to work alongside the doctors. Many people ...
Breaking Medicine News(10 mins):Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 2Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 3Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 4Health News:St. John’s Episcopal Hospital Hires New Chief Executive Officer 5Health News:HEALTHCAREfirst Announces Home Health Industry Regulatory Review Webinar 2Health News:CB-1 Weight Gainer Gives Three Tips on When to Eat to Gain Weight 2Health News:CB-1 Weight Gainer Gives Three Tips on When to Eat to Gain Weight 3Health News:Medicationdiscountcard.com Encourages Pre-Natal Wellness in Time for World Breast-Feeding Week 2Health News:Medicationdiscountcard.com Encourages Pre-Natal Wellness in Time for World Breast-Feeding Week 3Health News:Medicationdiscountcard.com Encourages Pre-Natal Wellness in Time for World Breast-Feeding Week 4Health News:AlignLife of Simpsonville Hires Massage Therapist 2
(Date:7/30/2015)... Health today reported fourth-quarter fiscal year 2015 revenues ... and non-GAAP diluted earnings per share (EPS) from ... percent. Non-GAAP operating earnings increased 33 percent to ... increased 44 percent to $558 million, and diluted ... $0.88. Fiscal year 2015 revenues increased ...
(Date:7/30/2015)... Ind., July 30, 2015 , Net Sales ... the prior year period and an increase of 5.7% constant ... second quarter was $(0.91), and adjusted earnings per share were ... , Company updates guidance Zimmer Biomet ... for the quarter ended June 30, 2015.  The Company reported ...
(Date:7/29/2015)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) today ... Test v2 for Premarket Approval (PMA) to the ... companion diagnostic test for AZD9291, an AstraZeneca investigational ... an acquired resistant mutation.  Patients ... with tumor containing an EGFR sensitizing mutation show ...
Breaking Medicine Technology:Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 2Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 3Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 4Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 5Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 6Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 7Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 8Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 9Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 10Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 11Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 12Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 13Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 14Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 15Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 16Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 17Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 18Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 19Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 20Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 21Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 22Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 23Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 24Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 25Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 26Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 27Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 28Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 29Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 30Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 31Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 32Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 33Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 34Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 35Cardinal Health Reports Strong Q4 And Record Fiscal Year-End Non-GAAP Operating Earnings Results 36
Cached News: