HOME >> MEDICINE >> NEWS
A fundamentally new approach to improving cancer chemotherapy

A new strategy for getting anti-cancer drugs to kill cancer cells, without causing serious harm to normal cells in the body, is reported in the current [June] issue of ACS Chemical Biology, a monthly peer-reviewed journal of the American Chemical Society.

The approach, tested in laboratory experiments with several existing anti-cancer drugs, could offer substantial benefits for cancer patients, according to Jeffrey P. Krise, Ph.D. Krise led a group of pharmaceutical and medicinal chemists at the University of Kansas at Lawrence who did the research.

The new approach would allow anticancer drugs to accumulate in both normal and malignant cells. The drugs, however, would be tweaked by giving them "basic" chemical properties. In chemistry, "basic" means an alkaline substance like baking soda or laundry detergent, which has properties opposite those of acidic substances.

Normal cells simply isolate anti-cancer drugs with basic properties, greatly reducing the toxic effects. Cancer cells, in contrast, have an impaired ability to isolate basic substances, and get hit with a full blast of toxicity.

"It could allow cancer patients to tolerate higher and more effective doses of chemotherapy before normal cells are damaged to an extent that causes serious side effects and cessation of therapy," Krise said. "The approach is completely different from previous attempts that were designed to deliver drugs only to cancer cells and not normal cells."

"The results of our studies should lead to the development of rationally designed molecules that are more selective and produce fewer side effects," Krise explained. "Importantly, this technology can also be used to modify existing drugs and increase their selectivity."

Krise's report describes a number of existing anti-cancer drugs that have basic properties, and notes that the new findings may provide the first explanation of why these drugs are so effective.

"There is ob
'"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-4400
American Chemical Society
5-Jun-2006


Page: 1 2

Related medicine news :

1. Patient-centered approach can backfire
2. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. Rosiglitazone -- Seeking a balanced approach to avoid panic among patients
5. Treatment of kidney condition requires an individualized approach
6. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression
7. Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
8. Combined imaging approach may provide better identification of difficult-to-diagnose brain clots
9. AHA statement recommends doctors change approach
10. Penn addiction researcher presents talk on promising approaches in the treatment of drug addiction
11. New data supports a non-invasive approach to routine prenatal genetic testing

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: fundamentally new approach improving cancer chemotherapy

(Date:8/21/2014)... The W. Montague Cobb/ NMA Health ... voice in the elimination of health disparities, honored ... 112th National Medical Association’s (NMA) Annual Convention and ... Ruffin, Ph.D, former Director of the National Institute ... career and innovations have had a significant impact ...
(Date:8/21/2014)... York, New York (PRWEB) August 21, 2014 ... filed against C.R. Bard, Inc. continue to move ... U.S. District Court, Southern District of West Virginia, ... Order issued on August 14th, the Court has ... evidence that requires special handling, division, storage and ...
(Date:8/21/2014)... A new study published this week in ... associated with speech problems from 2001-02 to 2010-11 among ... in disability associated with hearing problems. The data underscore ... children who are experiencing communication disorders, according to the ... a broader level, the new study, Changing Trends ...
(Date:8/21/2014)... Seattle, WA chiropractors Dr. Lincoln Kamell ... and Massage Center have recently welcomed two new ... Lang, LMP and Mike Larios, LMP have specialized training ... and have developed their expertise working in a variety ... in a clinical environment where massage is used on ...
(Date:8/21/2014)... To sexually objectify a woman is to focus on ... sexual pleasure rather than viewing her as a complete ... long been considered a problem in the media, how ... in Psychology of Women Quarterly , a SAGE ... body is related to higher incidents of sexual pressure ...
Breaking Medicine News(10 mins):Health News:W. Montague Cobb/NMA Health Institute Honors Three Outstanding Leaders in Health Disparities 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward in Federal C.R. Bard Litigation with Issuance of New Pretrial Order, Bernstein Liebhard LLP Reports 3Health News:New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade 2Health News:New Pediatrics Study Reveals Dramatic Increase in Speech Problems in Children Over Past Decade 3Health News:Seattle’s Eastlake Chiropractic and Massage Center Is Pleased to Introduce Rina Lang and Mike Larios as New Members of Its Massage Therapy Team 2Health News:Seattle’s Eastlake Chiropractic and Massage Center Is Pleased to Introduce Rina Lang and Mike Larios as New Members of Its Massage Therapy Team 3Health News:Objectification in romantic relationships related to sexual pressure and coercion 2
(Date:8/21/2014)... 2014 Nektar Therapeutics (NASDAQ: ... positive results from its Phase 3 pivotal clinical ... recombinant factor VIII (rFVIII) treatment for hemophilia A ... its primary endpoint in reducing annualized bleed rates ... on-demand arm. Top-line results from the ...
(Date:8/21/2014)... Texas , Aug. 21, 2014  eRelevance ... services company, announced today that it has completed ... (EMR) solution for Plastic Surgery and Dermatology practices. ... even more value to healthcare practices using Nextech," ... of eRelevance Corporation. "Using information from the EMR ...
(Date:8/21/2014)... , Aug. 21, 2014 The spinal column is ... human body. Signals carried to and from the brain through ... and nervous system. Injury or ailment here can be life ... a loss of control over their body. Though back injury ... person,s life, there are more options available to make things ...
Breaking Medicine Technology:Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 2Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 3Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 4Baxter Announces Positive Top-Line Results from Its Phase 3 Study of BAX 855, Extended Half-Life Recombinant FVIII for Hemophilia A Patients 5eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Don't Live in Pain: Four Life Improving Benefits of Back Surgery 2
Cached News: