A fundamentally new approach to improving cancer chemotherapy

A new strategy for getting anti-cancer drugs to kill cancer cells, without causing serious harm to normal cells in the body, is reported in the current [June] issue of ACS Chemical Biology, a monthly peer-reviewed journal of the American Chemical Society.

The approach, tested in laboratory experiments with several existing anti-cancer drugs, could offer substantial benefits for cancer patients, according to Jeffrey P. Krise, Ph.D. Krise led a group of pharmaceutical and medicinal chemists at the University of Kansas at Lawrence who did the research.

The new approach would allow anticancer drugs to accumulate in both normal and malignant cells. The drugs, however, would be tweaked by giving them "basic" chemical properties. In chemistry, "basic" means an alkaline substance like baking soda or laundry detergent, which has properties opposite those of acidic substances.

Normal cells simply isolate anti-cancer drugs with basic properties, greatly reducing the toxic effects. Cancer cells, in contrast, have an impaired ability to isolate basic substances, and get hit with a full blast of toxicity.

"It could allow cancer patients to tolerate higher and more effective doses of chemotherapy before normal cells are damaged to an extent that causes serious side effects and cessation of therapy," Krise said. "The approach is completely different from previous attempts that were designed to deliver drugs only to cancer cells and not normal cells."

"The results of our studies should lead to the development of rationally designed molecules that are more selective and produce fewer side effects," Krise explained. "Importantly, this technology can also be used to modify existing drugs and increase their selectivity."

Krise's report describes a number of existing anti-cancer drugs that have basic properties, and notes that the new findings may provide the first explanation of why these drugs are so effective.

"There is ob

Contact: Michael Bernstein
American Chemical Society

Page: 1 2

Related medicine news :

1. Patient-centered approach can backfire
2. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
3. Clinical review -- A psychological approach to the management of irritable bowel syndrome
4. Rosiglitazone -- Seeking a balanced approach to avoid panic among patients
5. Treatment of kidney condition requires an individualized approach
6. Mayo Clinic study finds heart transplant patients benefit from new approach to immunosuppression
7. Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment
8. Combined imaging approach may provide better identification of difficult-to-diagnose brain clots
9. AHA statement recommends doctors change approach
10. Penn addiction researcher presents talk on promising approaches in the treatment of drug addiction
11. New data supports a non-invasive approach to routine prenatal genetic testing

Post Your Comments:

(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
Breaking Medicine Technology:
Cached News: