HOME >> MEDICINE >> NEWS
A non-invasive method for measuring beta cell mass during diabetes

Diabetes results from a reduction in the number of islet beta cells in the pancreas, which leads to insufficient insulin secretion and high blood glucose levels (hyperglycemia). Currently, insulin secretion is used as a surrogate measure of beta cell mass. However serum insulin concentrations provide an imprecise measure of beta cell mass, and no reliable non-invasive measure of beta cell mass has been available, until now. In a study appearing online on May 18 in advance of print publication in the June issue of the Journal of Clinical Investigation, Paul Harris and colleagues from Columbia University in New York report that positron emission tomography (PET)-based quantitation of pancreatic radiolabeled VMAT2 receptors in diabetic rats is a reliable and non-invasive way to measure beta cell mass.

The authors exploited the finding that type 2 vesicular monoamine transporters (VMAT2) are expressed in human islet beta cells within the pancreas, as well as in tissues of the central nervous system. As the radioligand [11C]Dihydrotetrabenazine (DTBZ) binds specifically to VMAT2 and is currently used in clinical imaging of the brain, the authors were able to use DTBZ to estimate beta cell mass in rats with type 1 diabetes. In longitudinal PET studies, the authors saw a significant decline in pancreatic uptake of DTBZ that preceded the loss of glycemic control in the diabetic rat. These studies suggest that PET-based quantitation of VMAT2 receptors could provide a non-invasive measurement of beta cell mass that could be used to study the pathogenesis of diabetes and to monitor therapeutic interventions.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
18-May-2006


Page: 1

Related medicine news :

1. New data supports a non-invasive approach to routine prenatal genetic testing
2. New research explores limits of non-invasive coronary imaging tests
3. German researchers develop first non-invasive test to measure skin aging
4. Gamma Knife offers non-invasive treatment for vascular disorders, tumors in the brain
5. ESC recommends interdisciplinary collaboration in non-invasive imaging
6. Breast conservation a good option for non-invasive, early breast cancer, U-M study shows
7. NYU, Austrian researchers create non-invasive imaging method with advantages over conventional MRI
8. Merck investigational vaccine GARDASIL prevented 100 percent of cervical pre- & non-invasive cancers
9. New oxidation methods streamline synthesis of important compounds
10. U of M researchers discover new method to combat HIV
11. New prevention, treatment methods for patients with painful bowel inflammation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/11/2019)... ... November 11, 2019 , ... Early praise for A ... down the complexities of scholarly writing and provides key insight and vital guidance for ... DNP Project will have a permanent place on my bookshelf and will be shared ...
(Date:11/11/2019)... Calif. (PRWEB) , ... November 11, 2019 , ... ... of business support services to dental groups in the United States, today announced ... the community of Lodi, CA. , Patients will enjoy convenient hours, comfortable offices ...
(Date:11/11/2019)... LAS VEGAS (PRWEB) , ... November 11, 2019 , ... ... buyers from 46 different countries including big box buyers like Costco, Walmart, and GNC. ... CBDfx, and GRN to name a few. , This year, CBD.io ...
(Date:11/11/2019)... ... November 11, 2019 , ... Artemis, ... prevention and urges increased adoption of compliance technology in the wake of the ... sold to select retailers in the United States and Canada due to potential ...
(Date:11/11/2019)... ... 11, 2019 , ... PracticeLink Live! Atlanta Physician Career Fair will take place ... 5:00 p.m. and continue until 8:00 p.m. A free, optional seminar for job-seeking physicians, ... 6:30 p.m. , Both the career fair and seminar are open to residents and ...
Breaking Medicine News(10 mins):
(Date:11/15/2019)... ... 15, 2019 , ... Mold doesn’t need things to be wet in order ... detectable to the eye or by touch. ServPro in Cayucos , the mold ... explaining the conditions that mold needs to grow and how to prevent those conditions. ...
(Date:11/14/2019)... ... 2019 , ... Researchers at Worcester Polytechnic Institute (WPI) are ... blood oxygen levels, a vital indication of the lungs’ effectiveness and whether the ... this miniaturized wearable device will be flexible and stretchable, wireless, inexpensive, and mobile—possibly ...
(Date:11/14/2019)... (PRWEB) , ... November 14, 2019 , ... ... K-FISH, aimed to promote the quality of Korean seafood and enhance its global ... entitled, "K-Seafood Global Weeks" in many countries. These special events are currently ...
Breaking Medicine Technology:
Cached News: