HOME >> MEDICINE >> NEWS
A novel mechanism of manganese-induced neurological dysfunction discovered

For decades, scientists have known that chronic exposure to high concentrations of the metal manganese can cause movement abnormalities resembling symptoms of Parkinson's disease, but apparently without the same neuron damage characteristic of Parkinson's patients. Now, researchers from the Johns Hopkins Bloomberg School of Public Health and Thomas Jefferson University have discovered a potential explanation to why these neurological symptoms may occur with manganese exposure. The study found that dopamine neurons in the brain of animals exposed to manganese do not release dopamine when stimulated, suggestive of a dysfunctional dopamine system even though the neurons do not show the damage present with Parkinson's disease. Dopamine is a key neurotransmitter necessary for normal motor function. In addition, the researchers found that effects of manganese exposure occurred at blood concentrations in the upper range of levels documented in children and adults with environmental or occupational exposure. The study is published in the online version of the journal Experimental Neurology.

Manganese is a metal used in welding, battery making and in other industrial settings. In Canada, it replaced lead as a gasoline additive. Manganese, in the form of MMT, is approved in the United States as a gasoline additive but is not in use. The symptoms of "manganism" include behavioral and memory disturbances as well as Parkinson's-like symptoms. Tremors occur with movement as opposed to the resting tremors typical of Parkinson's disease.

"These findings may provide an explanation for some of the differences between manganism and idiopathic Parkinson's disease, as well as why patients with manganese-induced neurological symptoms do not seem to respond to traditional Parkinson's therapies," said the study's lead author, Toms R. Guilarte, PhD, a professor in the Department of Environmental Health Sciences at the Bloomberg School of Public Health.

For
'"/>

Contact: Tim Parsons
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
28-Aug-2006


Page: 1 2

Related medicine news :

1. Penn researchers discover novel pathway for increasing good cholesterol
2. UD scientists invent novel hydrogels for repairing, regenerating human tissue
3. New biotech company to commercialize novel UD gene-repair technology
4. A closer look inside our lungs -- Penn researchers develop 2 novel imaging techniques
5. European scientists receive funding from EU to develop novel therapy for cancer
6. Mass. General leading international trial of novel breast cancer drug
7. Researchers develop novel method for treatment of sickle cell disease
8. Researchers use novel three-dimensional imaging technique
9. New hope in cancer vaccines emerges as novel therapies are developed and tested
10. Mouse model aids discovery of novel melanoma metastasis gene
11. Study uncovers significant functional differences of novel estrogen receptor

Post Your Comments:
(Date:8/30/2014)... "My wife suffered neck, back and spine injuries ... of two inventors from Bethel, Alaska. "The whiplash contributed ... area. She tried other pillows to little avail. The ... comfort and providing extra sleep." , They created a ... head, neck and back comfortably. This enables the user ...
(Date:8/30/2014)... 30, 2014 "My niece developed a ... at any moment, her fever might get worse," said ... me well aware of how she was doing, I ... ALARM to continuously monitor a child's temperature. The unit ... This ensures that prompt medical care can be given, ...
(Date:8/30/2014)... York (PRWEB) August 30, 2014 ... transvaginal mesh lawsuits ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed against ... to sever four cases selected for one of ... issued on August 18, 2014, U.S. District Judge ... West Virginia disagrees with Boston Scientific’s contention that ...
(Date:8/30/2014)... In today’s world, a good night’s sleep has become especially ... (a medical problem where the airway collapses during sleep and ... rest they need to face their daily challenges. , ... people in the United States alone have sleep apnea. Of ... those treated, many cannot tolerate their prescribed medical device known ...
(Date:8/30/2014)... August 30, 2014 Top10BestSEOHosting.com is ... researchers have announced that HostGator.com http://secure.hostgator.com/~affiliat/cgi-bin/affiliates/clickthru.cgi?id=seohosts ... current market. Also, they has announced that Bluehost ... , Hostgator, one of the Top 10 ... of cheap Windows hosting, and it offers rich ...
Breaking Medicine News(10 mins):Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Top10BestSEOHosting.com: HostGator.com Is The Best Windows Hosting Supplier 2
(Date:8/29/2014)... 2014 Medina Medical announced today that Mr. ... the Board of Directors on August 18, 2014. Mr. ... commercialization experience, including over a decade of direct experience ... a Partner of the medical device incubator The Foundry, ... Foundry start-ups. Mr. Engelson previously served as the Chief ...
(Date:8/29/2014)... 29, 2014 Research and Markets ... Cancer Therapeutics Market & Pipeline Insight 2014" report ... developed to prevent and eradicate the prevalence of cancer ... are confined to low specificity, safety and large number ... for a better solution. It has been discovered that ...
(Date:8/29/2014)... -- Research and Markets has announced the ... of Pharmaceutical Equipment Market in China, 2014-2018" report ... Trend Forecast of Pharmaceutical Equipment Market in ... pharmaceutical equipment industry in the aspects of ... business performance of domestic major enterprises, as well as ...
Breaking Medicine Technology:Medina Medical Announces Erik T. Engelson Joins as Chief Executive Officer 2Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2Research and Development Trend Forecast of Pharmaceutical Equipment Market in China, 2014-2018 2
Cached News: