HOME >> MEDICINE >> NEWS
A novel mechanism of manganese-induced neurological dysfunction discovered

For decades, scientists have known that chronic exposure to high concentrations of the metal manganese can cause movement abnormalities resembling symptoms of Parkinson's disease, but apparently without the same neuron damage characteristic of Parkinson's patients. Now, researchers from the Johns Hopkins Bloomberg School of Public Health and Thomas Jefferson University have discovered a potential explanation to why these neurological symptoms may occur with manganese exposure. The study found that dopamine neurons in the brain of animals exposed to manganese do not release dopamine when stimulated, suggestive of a dysfunctional dopamine system even though the neurons do not show the damage present with Parkinson's disease. Dopamine is a key neurotransmitter necessary for normal motor function. In addition, the researchers found that effects of manganese exposure occurred at blood concentrations in the upper range of levels documented in children and adults with environmental or occupational exposure. The study is published in the online version of the journal Experimental Neurology.

Manganese is a metal used in welding, battery making and in other industrial settings. In Canada, it replaced lead as a gasoline additive. Manganese, in the form of MMT, is approved in the United States as a gasoline additive but is not in use. The symptoms of "manganism" include behavioral and memory disturbances as well as Parkinson's-like symptoms. Tremors occur with movement as opposed to the resting tremors typical of Parkinson's disease.

"These findings may provide an explanation for some of the differences between manganism and idiopathic Parkinson's disease, as well as why patients with manganese-induced neurological symptoms do not seem to respond to traditional Parkinson's therapies," said the study's lead author, Toms R. Guilarte, PhD, a professor in the Department of Environmental Health Sciences at the Bloomberg School of Public Health.

For
'"/>

Contact: Tim Parsons
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
28-Aug-2006


Page: 1 2

Related medicine news :

1. Penn researchers discover novel pathway for increasing good cholesterol
2. UD scientists invent novel hydrogels for repairing, regenerating human tissue
3. New biotech company to commercialize novel UD gene-repair technology
4. A closer look inside our lungs -- Penn researchers develop 2 novel imaging techniques
5. European scientists receive funding from EU to develop novel therapy for cancer
6. Mass. General leading international trial of novel breast cancer drug
7. Researchers develop novel method for treatment of sickle cell disease
8. Researchers use novel three-dimensional imaging technique
9. New hope in cancer vaccines emerges as novel therapies are developed and tested
10. Mouse model aids discovery of novel melanoma metastasis gene
11. Study uncovers significant functional differences of novel estrogen receptor

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... ... May 31, 2016 , ... The Global Wellness Summit ... predictions on the future of wellness, travel, spa and beauty in Europe. The organization ... beauty companies to leading economists and researchers - to forecast where wellness is headed ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Spectrum Aquatics ... This new lift has been designed and built with the user in mind. , ... aquatic consultants have informed us that an ADA 400 lbs lift is a necessary ...
(Date:5/31/2016)... (PRWEB) , ... May 31, 2016 , ... Phynd Technologies, ... Vidalia, GA; Houston Methodist – Houston, TX and Shore Medical Center – Somers Point, ... use three different, leading EHR solutions, demonstrating the breadth of Phynd’s solution and its ...
(Date:5/31/2016)... ... May 31, 2016 , ... MinerEye today announced that it ... Protection report by Gartner1 Inc. , Each year, Gartner identifies new Cool Vendors ... innovative vendors and their products and services. , According to Gartner, “Gartner's Cool ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... technology solutions to the healthcare industry, The University of Scranton is adding a ... accelerated path to a career in rapidly growing field of healthcare information. ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... , May 31, 2016 Mundipharma ... initiation of a first-in-human clinical trial of its investigational ... - S101 is currently being developed for the treatment ... is designed to evaluate the safety and tolerability of ... several sites across the United States ...
(Date:5/31/2016)... 31, 2016 PaperHive Will ... From Elsevier,s ScienceDirect Database Elsevier ... medical information products and services, today announced it ... scientific collaboration platform PaperHive to enable researchers to easily ... articles on ScienceDirect , the world,s largest ...
(Date:5/31/2016)... ZIONA, Israel , May 31, 2016 ... company utilizing its proprietary plant-based rhCollagen technology for tissue ... from the Chief Scientist of Israel,s ... its NIS 12 million development project for 2016. The Chief ... than last year,s authorized grant, which totaled NIS 4.7 ...
Breaking Medicine Technology:
Cached News: