A novel mechanism of manganese-induced neurological dysfunction ...( the study researchers observed a group...),Health

the study, researchers observed a group of animals that were given incremental levels of manganese. The animals were monitored for behavioral changes and Positron Emission Tomography (PET) was used to assess various markers of dopamine neurons in the brain. According to the study, in addition to decreased in vivo dopamine release, manganese exposure produced subtle deficits in behavior and fine motor function.

"More work is needed to understand the relationship between the changes in behavior and the alterations in the dopamine system," explained Jay S. Schneider, professor of pathology, anatomy and cell biology at Thomas Jefferson University and co-author of the study.

"There are other aspects of manganese neurotoxicity that this on-going study is examining that are likely to change the way that we view the risk of manganese exposure today," said Guilarte.

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Contact: Tim Parsons
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
28-Aug-2006

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