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ACTOS (pioglitazone HCl) to be studied in new trial

lcium (CAC): calcium build-up in the arteries of the heart in the same population. Heart disease and stroke account for 65% of deaths in patients with diabetes.

CHICAGO Data: Relationship Between Baseline Characteristics And Coronary Artery Calcium

A multivariable analysis, a tool for determining the relative contributions of different causes to a significant event, of over 30 traditional and emerging cardiac risk factors (including apolipoproteins, inflammatory and coagulation markers and visceral and total abdominal fat) confirmed that age, systolic blood pressure, gender, race/ethnicity, and triglyceride levels were significant predictors of CAC.

"There is a growing body of science suggesting that ACTOS may have benefits beyond glycemic control," said Robert Spanheimer, M.D., medical director for diabetes and metabolism at Takeda Pharmaceuticals North America, Inc. "CHICAGO will be viewed in the context of other large cardiovascular studies with ACTOS: the PROactive study, which found that ACTOS may reduce the combined risk of heart attack, stroke and death in high-risk patients with type 2 diabetes; and the PERISCOPE trial, which is studying the effects of ACTOS on progression or regression of atherosclerosis in the coronary arteries using intravascular ultrasound."


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Contact: Amy Losak
917-865-6688
Ketchum
9-Jun-2006


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