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AMITIZA(TM) (lubiprostone) shown effective and well-tolerated in people older than age 65

AMITIZA(TM) (lubiprostone), the first selective chloride channel activator for the treatment of chronic idiopathic constipation, was effective and well-tolerated in treating the symptoms of chronic idiopathic constipation in the elderly adult population according to findings presented during a poster session today at Digestive Disease Week 2006.

"AMITIZA is unique among prescription treatments for chronic idiopathic constipation, given its novel mechanism of action, which has been shown to provide targeted and predictable relief to people living with this condition," said John Johanson, M.D., clinical associate professor, University of Illinois College of Medicine. "These results further support that AMITIZA may fill an important unmet need for many patients, especially those over age 65, for whom there are limited prescription treatment options currently available to treat chronic idiopathic constipation."

Predictable relief is defined as the ability of study participants to have three spontaneous bowel movements or more per week.

Constipation is one of the most common digestive complaints, affecting more than 30 million Americans, and is especially prevalent in adults over the age of 65. It is the cause of 2.5 million visits to physicians and 92,000 hospitalizations annually. AMITIZA is the only prescription medication for chronic idiopathic constipation that can be used in people age 65+ for longer than two weeks. Approximately one of four patients over 65 suffers from chronic constipation, a condition that increases with age-related bowel changes.

AMITIZA, approved by the U.S. Food and Drug Administration (FDA) in January 2006, is an oral treatment that works by increasing fluid secretion in the small intestine by activating ClC-2 chloride channels, and thereby increasing the passage of the stool and improving symptoms associated with chronic idiopathic constipation. AMITIZA was developed by Sucampo Pharmaceuticals, Inc., an
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Contact: Jocelyn M. Gerst
847-383-3696
Ketchum
22-May-2006


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