HOME >> MEDICINE >> NEWS
AMPAKINE compounds a new potential treatment for respiratory depression

Drug-induced respiratory depression is a life-threatening condition caused by analgesic, hypnotic, and anesthesia medications. Although it is a leading cause of death from the overdose of some classes of abused drugs, respiratory depression also arises during normal, physician-supervised procedures such as surgical anesthesia, post-operative analgesia, and as a result of normal out-patient management of pain from cancer, accidents, or illnesses.

The majority of adverse events occurring with these drugs take place during the dose adjustment period, when two or more central nervous depressants are taken together, or when patients take prescribed drugs in ways not intended by their physician.

Although only 0.5%-1.2% of total adverse drug events caused by prescription medications are respiratory in nature, these serious side effects account for 25%-30% of drug-induced deaths. Opiates and barbiturates are the primary drugs classes responsible for these effects. Opiates include the standard pain-killing drugs morphine, fentanyl, and codeine, as well as related products vicodin, hydrocodone, and oxycontin. Barbituates comprise the sedative drugs amobarbital, aprobarbital, butabarbital, pentobarbital, and others. Sleeping disorders are another common predisposing factor for respiratory depression, in this case known as sleep apnea.

Currently, the only way to counter opiate-induced respiratory depression is to administer opiate receptor antagonists, drugs that block the effectiveness of opiate analgesia. While this approach may prevent a serious side effect or even death, it dramatically reduces the effectiveness of drugs administered for management of severe pain.

Researchers at the University of Alberta (Edmonton, AB) and Cortex Pharmaceuticals (Irvine, CA) believe that AMPAKINE drugs may provide protection from drug-induced respiratory depression, while simultaneously allowing the sedative or analgesic to continue working as it
'"/>

Contact: Mark Varney
mvarney@cortexpharm.com
949-231-0672
Cortex Pharmaceuticals
4-Jun-2007


Page: 1 2 3 4 5

Related medicine news :

1. New oxidation methods streamline synthesis of important compounds
2. Depression among retired NFL players: Rates mirror the general public, but pain compounds symptoms
3. U of M researchers discover compounds to shrink tumors
4. Diagnosis and treatment of osteoporosis falls shortnon adherence compounds issue
5. New compounds fight chronic symptoms of bowel disorders
6. New synthetic compounds appear to prevent brain cell death
7. Phenolic compounds may explain Mediterranean diet benefits
8. Vitamin D compounds show promise for prevention of prostate cancer
9. Hebrew University researcher develops compounds to control bacteria
10. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
11. Electric fields have potential as a cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/18/2018)... , ... October 18, 2018 , ... ... announced it has joined the Strategic Health Information Exchange Collaborative (SHIEC) as a ... health information exchanges (HIEs). , Drummond Group is a HITRUST CSF Assessor ...
(Date:10/18/2018)... ... , ... Fellow Health Partners, Inc. , a New York based medical ... agreed to join its Advisory Board. , CEO Michael N. Brown said, “This advisory ... guide Fellow Health Partners. They will provide strategic as well as tactical, ‘front lines’ ...
(Date:10/17/2018)... ... October 17, 2018 , ... A ... Human Rights identifies best practices in the management of lesbian, bisexual, gay, transgender, ... LGBT youth are overrepresented in the juvenile justice system, especially lesbian and bisexual ...
(Date:10/16/2018)... ... October 16, 2018 , ... With a petition (case CJ-2018-04177) filed last week ... joins a series of lawsuits filed in states around the country against Massage Envy ... locations by Massage Envy’s massage therapists. , This lawsuit alleges that the company's ...
(Date:10/16/2018)... ... October 16, 2018 , ... 13th Annual FDA ... http://www.fdanews.com/fdainspectionssummit , The 13th Annual FDA Inspections Summit starts in one week. ... feels difficult to keep up. The FDA is focused on any number of ...
Breaking Medicine News(10 mins):
(Date:10/17/2018)... ... October 17, 2018 , ... WHAT: , Hosted by ... high-growth niche markets, Artificial Intelligence in Healthcare Conference will bring together ... learn from leading experts who are developing and deploying the technology. The industry ...
(Date:10/16/2018)... Mich. (PRWEB) , ... October 16, 2018 , ... ... Michigan Dental Association , is creating a strategic alliance with The Dentists ... of organized dentistry significant savings on a robust catalog of dental supplies through ...
(Date:10/16/2018)... (PRWEB) , ... October 16, 2018 , ... ... of Applied Logic, the St. Louis based surgical tracking software company. Censis is ... their customers and employees to make a difference using their strong portfolio of ...
Breaking Medicine Technology:
Cached News: