HOME >> MEDICINE >> NEWS
AMPAKINE compounds a new potential treatment for respiratory depression

was intended.

The drug tested in this study belongs to a novel class of molecules known as AMPAKINE compounds being developed by Cortex Pharmaceuticals, Inc. located in Irvine, California. AMPAKINE compounds act on the most common excitatory receptor in the brain, the AMPA "Glutamate type receptor," which has been shown in rodent models to boost the brain's own protein for improving age-related deficits in memory mechanisms. In primate models AMPAKINE compounds have replicated the studies in rodents and in adults patients suffering from Attention Deficit Hyperactivity Disorder, significant clinical and statistical improvement in increase attention and decrease hyperactivity have been observed. The U. Alberta research provide evidence that another important AMPAKINE indication is to stimulate primitive areas of the brain called the pre-Botzinger Complex responsible for breathing, without causing side effects. The pre-Botzinger Complex generated respiratory-related oscillations similar to those generated by the whole brainstem in vitro, and neurons with voltage-dependent pacemaker-like properties that have been identified in this brain region.

In a study published in 2006, Dr. John J. Greer of U. Alberta demonstrated that certain AMPAKINE compounds enhance the respiratory drive and breathing rhythm at the brain-stem level containing the pre-Botzinger Complex in laboratory rats whose respiration rates were purposely suppressed by administration of central nervous system depressants.

Dr. Greer found that respiratory depression induced by these agents can be reversed or prevented in test animals with an experimental AMPAKINE drug, without a reduction of pain relief or sedation.

Greer and coworkers treated rats with the opioids analgesic fentanyl or the barbiturate sedative Phenobarbital, both commonly prescribed in the United States. Greer used a technique known as plethysmography, which measures blood flow throughout
'"/>

Contact: Mark Varney
mvarney@cortexpharm.com
949-231-0672
Cortex Pharmaceuticals
4-Jun-2007


Page: 1 2 3 4 5

Related medicine news :

1. New oxidation methods streamline synthesis of important compounds
2. Depression among retired NFL players: Rates mirror the general public, but pain compounds symptoms
3. U of M researchers discover compounds to shrink tumors
4. Diagnosis and treatment of osteoporosis falls shortnon adherence compounds issue
5. New compounds fight chronic symptoms of bowel disorders
6. New synthetic compounds appear to prevent brain cell death
7. Phenolic compounds may explain Mediterranean diet benefits
8. Vitamin D compounds show promise for prevention of prostate cancer
9. Hebrew University researcher develops compounds to control bacteria
10. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
11. Electric fields have potential as a cancer treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... CA (PRWEB) , ... May 03, 2016 , ... ... is a process that selects DNA or RNA from a random library of ... potentially be used as drugs or diagnostic agents. SELEX selection is commonly performed ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... creative director Joe Ferrazano to serve in the newly created position of executive ... overseeing the agency’s creative efforts in the Chicago and LA offices. He reports ...
(Date:5/3/2016)... ... , ... Elizabeth Murray has always loved walking one to two miles a ... shoulder and one on her arm. But she got to the point where she ... prolapse. , The valves of the heart wouldn’t close properly resulting in mitral regurgitation, ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... Excessive panting ... signs of pet anxiety. "Pet owners often think anxiety only manifests itself as ... signals in other ways, and there’s things that be done about it,” says Dr. ...
(Date:5/3/2016)... ... May 03, 2016 , ... Diagnotes, a ... Tidelands Health, a three hospital system in South Carolina, to provide its secure ... for technology that enhances communication, drives workflow efficiencies and improves provider and patient ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... PUNE, India , May 3, 2016 /PRNewswire/ ... Market 2016 Research Report provides a basic overview ... manufacturing technology, post which the surgical mesh report ... the market. Complete report on Surgical ... company profiles and 98 tables and figures is ...
(Date:5/2/2016)... 2016  While nearly three-quarters of Americans (71%) are ... their health, only about half report taking any steps ... of a new survey announced today by Hologic (Nasdaq: ... National Osteoporosis Month, Hologic is raising awareness of this ... million Americans. Osteoporosis is a disease that ...
(Date:4/29/2016)... 29, 2016 Acquisition Expands ... Product Development Capabilities in North America ... . Indegene ( http://www.indegene.com ), ... acquisition of Skura Corporation,s life science business. Skura,s ... sales enablement technology for life science organizations and ...
Breaking Medicine Technology:
Cached News: