HOME >> MEDICINE >> NEWS
AMPAKINE compounds a new potential treatment for respiratory depression

was intended.

The drug tested in this study belongs to a novel class of molecules known as AMPAKINE compounds being developed by Cortex Pharmaceuticals, Inc. located in Irvine, California. AMPAKINE compounds act on the most common excitatory receptor in the brain, the AMPA "Glutamate type receptor," which has been shown in rodent models to boost the brain's own protein for improving age-related deficits in memory mechanisms. In primate models AMPAKINE compounds have replicated the studies in rodents and in adults patients suffering from Attention Deficit Hyperactivity Disorder, significant clinical and statistical improvement in increase attention and decrease hyperactivity have been observed. The U. Alberta research provide evidence that another important AMPAKINE indication is to stimulate primitive areas of the brain called the pre-Botzinger Complex responsible for breathing, without causing side effects. The pre-Botzinger Complex generated respiratory-related oscillations similar to those generated by the whole brainstem in vitro, and neurons with voltage-dependent pacemaker-like properties that have been identified in this brain region.

In a study published in 2006, Dr. John J. Greer of U. Alberta demonstrated that certain AMPAKINE compounds enhance the respiratory drive and breathing rhythm at the brain-stem level containing the pre-Botzinger Complex in laboratory rats whose respiration rates were purposely suppressed by administration of central nervous system depressants.

Dr. Greer found that respiratory depression induced by these agents can be reversed or prevented in test animals with an experimental AMPAKINE drug, without a reduction of pain relief or sedation.

Greer and coworkers treated rats with the opioids analgesic fentanyl or the barbiturate sedative Phenobarbital, both commonly prescribed in the United States. Greer used a technique known as plethysmography, which measures blood flow throughout
'"/>

Contact: Mark Varney
mvarney@cortexpharm.com
949-231-0672
Cortex Pharmaceuticals
4-Jun-2007


Page: 1 2 3 4 5

Related medicine news :

1. New oxidation methods streamline synthesis of important compounds
2. Depression among retired NFL players: Rates mirror the general public, but pain compounds symptoms
3. U of M researchers discover compounds to shrink tumors
4. Diagnosis and treatment of osteoporosis falls shortnon adherence compounds issue
5. New compounds fight chronic symptoms of bowel disorders
6. New synthetic compounds appear to prevent brain cell death
7. Phenolic compounds may explain Mediterranean diet benefits
8. Vitamin D compounds show promise for prevention of prostate cancer
9. Hebrew University researcher develops compounds to control bacteria
10. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
11. Electric fields have potential as a cancer treatment

Post Your Comments:
(Date:3/4/2015)... 04, 2015 The ability of ... density assessment and help improve breast cancer risk ... accepted for presentation at the European Congress of ... abstracts - eight posters and 2 session presentations ... breast density and quantitative breast imaging software tools ...
(Date:3/4/2015)... Surrey, BC (PRWEB) March 04, 2015 ... will perform LASIK and PRK procedures at their new ... Vision Correction, Dr. Joseph King and Dr. Gabriel Chu ... ophthalmology practice in Surrey is named Fraser Valley Cataract ... facility is accredited by the College of Physicians and ...
(Date:3/4/2015)... State officials have awarded $82,500 to ... Public Health at Georgia State University, to support the ... Georgia’s Division of Family and Children Services (DFCS) as ... Center. , The 1-800-CHILDREN Helpline is a top ... referral services that promote the wellbeing of children while ...
(Date:3/4/2015)... 04, 2015 Organic Valley, the nation’s largest ... announced its cause campaign to Save the Bros, http://savethebros.com/ ... making a difference to Bros everywhere. To date, the ... Facebook. The video was named Adweek’s best commercial of ... Mashable and Digiday, among other media outlets. , “We ...
(Date:3/4/2015)... PEACHTREE CITY, GA (PRWEB) March 04, 2015 ... their exclusive advanced microfiber technology and their first compression ... the huge success of this collection, SIGVARIS USA is ... in the MIDTOWN MICROFIBER product line. , Constructed from ... designed with all-day comfort in mind. These socks and ...
Breaking Medicine News(10 mins):Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 2Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 3Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 4Health News:Research Finds Use of Volpara Solutions’ Quantitative Breast Imaging Tools Help Reduce Subjectivity in Density Assessment and Improve Breast Cancer Risk Prediction 5Health News:King LASIK relocates to Surrey, British Columbia 2Health News:State Funds Child Abuse Helpline Housed At Georgia State 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 3Health News:Building on the Success of MIDTOWN MICROFIBER, SIGVARIS Expands Popular Compression Collection with Longer Foot Length Offerings 2
(Date:3/4/2015)... , March 4, 2015 Aethlon Medical, Inc. ... address infectious diseases and cancer, today announced that ... to present a corporate overview at the 27th Annual ... Hotel in Laguna Niguel, California . ... ( http://www.roth.com/main/page.aspx?PageID=7207 ). A live webcast of ...
(Date:3/4/2015)... , March 4, 2015  Students from Indiana University ... how new medicines are discovered. Through a partnership with ... medical students from IU School of Medicine are learning ... at Lilly play different and important roles in bringing ... a former medical educator, scientific investigator, and health system ...
(Date:3/4/2015)... LAKE CITY , March 4, 2015  ECR ... VAR ) is showcasing a full spectrum of ... improve image quality, reduce costs, and enable greater patient ... cone-beam CT imaging systems.  These solutions are on display ... in Vienna, Austria this week.   ...
Breaking Medicine Technology:Aethlon Medical to Present at the 27th Annual ROTH Conference 2Lilly and IU School of Medicine Partner on Rotation Program for Medical Students 2Lilly and IU School of Medicine Partner on Rotation Program for Medical Students 3Varian Medical Systems to Showcase New X-Ray Imaging Components at the European Congress of Radiology (ECR) Annual Meeting 2Varian Medical Systems to Showcase New X-Ray Imaging Components at the European Congress of Radiology (ECR) Annual Meeting 3
Cached News: