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Advances in screening and markers improve early detection of colorectal cancer

resolution capabilities. The patients were randomly assigned to white light (141 patients) or NBI (135 patients) during the first withdrawal, and then immediately underwent a second examination by the same physician using white light.

The study found an overall miss rate of 12 percent for tumors of any size and three percent for tumors greater than or equal to six millimeters. No lesion larger than one centimeter was missed and all missed tumors were tubular adenomas, or non-cancerous tumors. Based on these results, researchers established the colorectal tumor miss rate as zero percent (up to 2%) for significant tumors and 12 percent for all tumors. However, no significant difference of missed lesions was found between NBI and white light.

"Our findings suggest that technological advances have led to a significant reduction in the overall colorectal tumor miss rate, establishing a new benchmark for more accurate screening and detection," said Roy Soetikno, M.D., of Stanford University in Stanford, Calif., and senior author of the study. "Our study reaffirms the role of colonoscopy as the gold standard method to screen for colorectal cancer."

Dr. Soetikno will present this study on Wednesday, May 23, at 8:35 a.m. in Ball Room AB.

The Association of Elevated C-Reactive Protein Levels with Synchronous and Advanced Colorectal Adenoma (Abstract #S1987)

Inflammation has been implicated in numerous diseases through recent research. High levels of C-reactive protein (CRP) a protein found in the blood that can be used to detect or grade inflammation are often associated with cardiovascular disease and cancers, such as colorectal cancer. Little is known, however, about CRP levels and non-cancerous colorectal tumors (adenomas) that precede colorectal cancer. Researchers from National Taiwan University Hospital in Taipei, Taiwan, examined levels of CRP in both men and women, finding that elevated levels may be
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Contact: Aimee Frank
AFrank@gastro.org
301-941-2620
American Gastroenterological Association
23-May-2007


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