Advances in screening and markers improve early detection of colorectal cancer

associated with increased risk of colorectal adenoma, but only in men.

Study authors conducted a cross-sectional study of plasma CRP levels in 6,695 Chinese patients. All patients underwent a complete total colonoscopy and thorough health check-up. Results were adjusted for age, gender, history of colon polyp, diabetes, hypertension, hypertriglyceridemia, hypercholesterolemia, physical activity, alcohol intake, smoking, white blood cell counts and abdominal obesity.

Results demonstrated that plasma CRP levels were significantly higher in patients in whom colorectal tumors were forming when compared to patients without tumor development. The presence of tumors forming at the same time, known as synchronous neoplasia, and advanced tumor development were associated with elevated levels of plasma CRP. However, while researchers found that high CRP levels are associated with the risk of colorectal tumor formation in male patients, the study did not find a corresponding association with female patients.

"These findings support the crucial role of chronic inflammation in the development of colorectal cancer," said Han-Mo Chiu, M.D., of the National Taiwan University Hospital, and senior author of this study. "These data warrant further investigations that will continue to evaluate C-reactive protein levels as an indicator of colorectal cancer and examine the gender differences found in our study."

Dr. Chiu will present this study on Sunday, May 20, at 8:00 a.m. in Hall E.


Contact: Aimee Frank
American Gastroenterological Association

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