HOME >> MEDICINE >> NEWS
Agent protects cells from lethal effects of radiation even if given after exposure

No drugs exist to protect the public from the high levels of radiation that could be released by a "dirty" bomb or nuclear explosion. Such excessive exposure typically causes death within weeks as the radiation kills blood cells vital to clotting and fighting infection, along with the stem cells needed to replenish their supply. But now researchers at Washington University School of Medicine in St. Louis report they have developed an agent that protects cells from the lethal effects of radiation, regardless of whether it is given before or after exposure.

Using this agent in mice, the investigators found that the treatment helped shield rapidly dividing cells that are most vulnerable to radiation-induced death, providing proof in principle that it is possible to fend off radiation damage, according to a study published in the April issue of Biochemical and Biophysical Research Communications.

Current treatments for severe radiation exposure, also called acute radiation syndrome, are limited to drugs that boost the production of blood cells and platelets, but this approach is futile if underlying stem cells are also killed off. Moreover, there are no available treatments that can be given after exposure to limit damage to cells.

"We are using an entirely different approach," says Clayton Hunt, Ph.D., of the Department of Radiation Oncology. "Rather than ramp up the production of blood cells, we are trying to prevent radiation-induced cell death from occurring in the first place."

The researchers developed the agent by attaching a portion of the Bcl-xL protein already known to block cell death - a snippet called BH4 - to the HIV protein TAT, which can deftly carry other molecules into cells. They gave the agent intravenously to mice exposed to 5 Grays of radiation. In humans, this level of exposure would cause a sharp drop in blood cells, leaving individuals with an increased risk of infection and bleeding.

They fou
'"/>

Contact: Caroline Arbanas
arbanasc@msnotes.wustl.edu
314-286-0109
Washington University School of Medicine
8-May-2007


Page: 1 2 3

Related medicine news :

1. Agent slows aging in mice
2. Veterans exposed to Agent Orange have higher rates of prostate cancer recurrence
3. Agent protects Parkinsons neurons from rotenone toxicity
4. American Society of Travel Agents urges healthy travel for consumers
5. Green tea extract protects against brain damage in new mouse model of HIV-related dementia
6. Extra cortisol protects womens mood under stress
7. Fatty fish protects against cancer
8. Experimental vaccine protects lab animals against several strains of H5N1
9. Vaccine given post-exposure protects monkeys against deadly Marburg virus
10. Research suggests that immune response protects against brain tumor development
11. Yale researchers identify gene depth protects against kidney stones

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2020)... ... ... The value of healthy vision can’t be overstated, and the most potent ... doctor, Brent Bellotte MD., champions such proactive care, advising that annual examinations are pivotal ... that many take for granted until a problem occurs. Eye disease is very common ...
(Date:1/10/2020)... (PRWEB) , ... January 10, 2020 , ... ... located in Portland, Oregon, provides a friendly, non-intimidating environment for all women. In ... Balanced Habits to its current and prospective members. , For nearly 30 ...
(Date:1/8/2020)... ... 2020 , ... Pyxa Solutions, a leading provider of consulting, ... is rebranding as Red Nucleus R&D, a division of Red Nucleus. Red Nucleus ... industry. , The addition of Red Nucleus R&D under the Red Nucleus ...
(Date:1/8/2020)... ... January 08, 2020 , ... ... in Living Magazine’s 2019 Best of Memorial Readers’ Choice Awards. Located ... skincare. Being named Best MedSpa in Memorial reflects Mirror Mirror Beauty Boutique’s commitment ...
(Date:1/8/2020)... ... 2020 , ... Quality Health Care Concierge was founded by Michelle ... maintain a comfortable and preferred lifestyle with their Companion Care services in the Boca ... has been a leader in the healthcare field for over a decade. Thanks to ...
Breaking Medicine News(10 mins):
(Date:1/8/2020)... ... January 08, 2020 , ... ... compliance consulting, is proud to announce the attainment of a national certification as ... certifying partner of the Women’s Business Enterprise National Council (WBENC). , "We are ...
(Date:1/7/2020)... ... January 07, 2020 , ... Valencell ... sensor system for integration in hearables and wearables. Valencell will provide the BP ... for inclusion in their products. Embedded in an earbud reference design, the technology ...
(Date:1/5/2020)... , ... January 04, 2020 , ... ... worldwide. Device makers and software firms are fighting for leadership in both devices ... Wellbeing 2020 research report, during the past few years, multiple health-related voice ...
Breaking Medicine Technology:
Cached News: