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Alcohol-deterrent drugs help patients achieve high rates of long-term abstinence

  • A nine-year study looks at the impact of alcohol deterrents (ADs) disulfiram and calcium carbimide.
  • Researchers found an abstinence rate of more than 50 percent among the patients studied.
  • ADs appear to play a major psychological role in relapse prevention.

Studies investigating the long-term outcomes of alcoholism treatment are rare and inconsistent. A nine-year study in the January issue of Alcoholism: Clinical & Experimental Research investigates the occurrence of abstinence, lapse, and relapse among chronic alcoholics while exploring the role that "alcohol deterrents" (ADs) specifically, disulfiram and calcium carbimide may play. Results indicate that ADs can help achieve an abstinence rate of more than 50 percent.

"Although up to 30 percent of patients may claim to be abstinent two to three years after treatment," said Hannelore Ehrenreich, head of the division of clinical neuroscience at the Max-Planck-Institute of Experimental Medicine in Germany and corresponding author for the study, "objective laboratory data indicate that only six to 20 percent of patients are abstinent two years after therapy. These results reflect therapists' clinical experience that alcoholism is a chronic and relapsing disease similar to other chronic conditions such as hypertension or diabetes, and should be accepted as a disorder that requires long-term or life-long treatment. This study is the first report on supervised, long-term administration of ADs, with a focus on the psychological rather than the pharmacological action of ADs."

Alcohol deterrents seem to be more widely accepted and used in Europe than they are in North America, said Colin Brewer, research director of the Stapleford Centre in London. "I have co-authored a study showing that the three 'Anglo-Saxon' countries examined the U.K, U.S. and New Zealand had the lowest use," he said. "Furthermore, a recent U.S. study show
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