HOME >> MEDICINE >> NEWS
Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level

Alzheimer's disease, Parkinson's disease, type 2 diabetes, the human version of mad cow disease, and other degenerative diseases are more closely related at the molecular level than scientists realized, a team reports this week in an advanced online publication of the journal Nature.

While still preliminary, the research, could help scientists develop tools for diagnosing such diseases, and potentially for treating them through "structure-based drug design," said David Eisenberg, a UCLA chemist and molecular biologist who is part of the research team.

The researchers studied the harmful rope-like structures known as amyloid fibrils--linked protein molecules that form in the brain. The fibrils contain a stack of water-tight "molecular zippers."

"With each disease, a different protein transforms into amyloid fibrils, but all of these diseases are similar at the molecular level," Eisenberg said.

If the molecular zipper is universal in amyloid fibrils, as Eisenberg believes, is it possible to pry open the zipper or prevent its formation?

Eisenberg's research team used X-ray analysis and a sophisticated computer algorithm to study proteins known to be associated with human diseases. When the computer said a protein will form an amyloid fibril, it almost always did. And one team member is experimenting with various compounds to break up the fibrils.

"Structural analysis of micro-crystals of proteins is an example of how basic research can have a profound impact on our understanding of health, biotechnology and other practical issues," said Parag Chitnis, program director in National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences.


'"/>

Contact: Cheryl Dybas
cdybas@nsf.gov
703-292-7734
National Science Foundation
30-Apr-2007


Page: 1

Related medicine news :

1. Breakdown of myelin implicated in Alzheimers, UCLA research shows
2. Young drug abusers suffer brain damage similar to early Alzheimers, says new research
3. Adverse housing conditions contribute to diabetes risk
4. RAND finds cases of undiagnosed diabetes drop sharply
5. Adverse housing conditions contribute to diabetes risk
6. Decision aid for diabetes
7. Wesley Research Institute study targets pharmacists to help diabetes sufferers
8. Diabetes professionals join forces to identify gaps in diabetes care and better self care
9. Study shows Diachrome improves blood sugar control in people with type 2 diabetes
10. Study tests oral insulin to prevent type 1 diabetes
11. Complications of type 2 diabetes in young people -- a ticking bomb

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Alzheimer Parkinson type diabetes similar molecular level

(Date:4/19/2015)... 2015 Carinsurancehints.com has released a new blog ... claim auto insurance benefits . , Drivers who ... all the necessary information for claiming auto insurance benefits. Exchanging ... plan to cover most of the damages. The newly released ... an accident. , Drivers can compare online rates and ...
(Date:4/19/2015)... April 19, 2015 The American Institute ... with PROSHRED Security (“PROSHRED”) to host its second annual, ... shred their personal documents in order to raise funds ... , The June 6th event is being held at ... 2pm local time. The time will vary at select ...
(Date:4/19/2015)... HealthPostures, LLC , a leading ... exhibit it’s pioneering ergonomics products at the Wisconsin Safety ... Council Professional Development Conference and Expo . The products, ... used in volume by call centers, educational organizations, retailers, ... clamp to a desk, the TaskMate Go 6350 and ...
(Date:4/18/2015)... Carinsurancesavings.biz has released a new blog post explaining ... Spring. , Spring can be a great season ... sure they compare the newest policies before deciding on ... about Spring car insurance offers by reading the newly ... becoming more and more popular. Many insurance brokerage websites ...
(Date:4/18/2015)... Insuranceautoquote.info has released a new blog post ... . , Clients can review important auto insurance ... environment provides important advantages for clients who need affordable ... do not have coverage for their vehicles can purchase ... or hour. Many agencies offer important discounts and drivers ...
Breaking Medicine News(10 mins):Health News:An Online Guide About Claiming Auto Insurance Benefits After an Accident 2Health News:2015 Annual Nationwide "Shred Cancer" Shredding Event 2Health News:HealthPostures' TaskMate Products to be Exhibited at the Wisconsin and Iowa-Illinois Safety Conferences 2Health News:Auto Insurance Plans Are Cheaper During Spring! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2
(Date:4/17/2015)... - The issue: In consultation ... lot (lot 710535) of Clavulin-400 (70mL) after receiving a complaint ... in one bottle of the  product. No other lots of ... Clavulin-400 is an oral antibiotic used in adults and children ... Clavulin-400 comes as a powder in bottles and is mixed ...
(Date:4/17/2015)... , April 17, 2015 Contego ... Integrated Embolic Protection™ filter platform for angioplasty balloon ... a $5.6 million Series B financing round led ... firm with a focus on medical devices, biopharmaceuticals, ... round also included Mountain Group Partners, Lookout Capital ...
(Date:4/17/2015)... April 17, 2015  Regulatory leaders in the pharmaceutical ... discussion draft called "21 st Century Cures." ... be taken up by Congress soon and if enacted ... device products are developed and marketed in ... companies have begun to consider how the proposed changes ...
Breaking Medicine Technology:Advisory - Clavulin-400 liquid oral antibiotic: One lot recalled after glass pieces found in one bottle 2Contego Medical Closes $5.6 Million in Series B Funding 2Contego Medical Closes $5.6 Million in Series B Funding 321st Century Cures: A Regulatory Game-Changer for the Pharmaceutical Industry 2
Cached News: