HOME >> MEDICINE >> NEWS
Alzheimer's, Parkinson's, type 2 diabetes similar at molecular level

Alzheimer's disease, Parkinson's disease, type 2 diabetes, the human version of mad cow disease, and other degenerative diseases are more closely related at the molecular level than scientists realized, a team reports this week in an advanced online publication of the journal Nature.

While still preliminary, the research, could help scientists develop tools for diagnosing such diseases, and potentially for treating them through "structure-based drug design," said David Eisenberg, a UCLA chemist and molecular biologist who is part of the research team.

The researchers studied the harmful rope-like structures known as amyloid fibrils--linked protein molecules that form in the brain. The fibrils contain a stack of water-tight "molecular zippers."

"With each disease, a different protein transforms into amyloid fibrils, but all of these diseases are similar at the molecular level," Eisenberg said.

If the molecular zipper is universal in amyloid fibrils, as Eisenberg believes, is it possible to pry open the zipper or prevent its formation?

Eisenberg's research team used X-ray analysis and a sophisticated computer algorithm to study proteins known to be associated with human diseases. When the computer said a protein will form an amyloid fibril, it almost always did. And one team member is experimenting with various compounds to break up the fibrils.

"Structural analysis of micro-crystals of proteins is an example of how basic research can have a profound impact on our understanding of health, biotechnology and other practical issues," said Parag Chitnis, program director in National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences.


'"/>

Contact: Cheryl Dybas
cdybas@nsf.gov
703-292-7734
National Science Foundation
30-Apr-2007


Page: 1

Related medicine news :

1. Breakdown of myelin implicated in Alzheimers, UCLA research shows
2. Young drug abusers suffer brain damage similar to early Alzheimers, says new research
3. Adverse housing conditions contribute to diabetes risk
4. RAND finds cases of undiagnosed diabetes drop sharply
5. Adverse housing conditions contribute to diabetes risk
6. Decision aid for diabetes
7. Wesley Research Institute study targets pharmacists to help diabetes sufferers
8. Diabetes professionals join forces to identify gaps in diabetes care and better self care
9. Study shows Diachrome improves blood sugar control in people with type 2 diabetes
10. Study tests oral insulin to prevent type 1 diabetes
11. Complications of type 2 diabetes in young people -- a ticking bomb

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Alzheimer Parkinson type diabetes similar molecular level

(Date:3/3/2015)... March 03, 2015 In March, 1% ... networks, will kick off a new campaign, “Know Your Source,” ... businesses, nonprofits, and ambassadors in their quest for ingredient awareness ... with several of its members and partners, including King Arthur ... Once network, to raise awareness for food as an environmental ...
(Date:3/3/2015)... Dallas, TX (PRWEB) March 04, 2015 ... comprehensive information on the therapeutic development for Alopecia. Alopecia ... alopecia are the two main types of alopecia. Causes ... autoimmune disorder. Symptoms of alopecia may include male pattern ... and broken hair. Alopecia can be classified as focal ...
(Date:3/3/2015)... US Air Purifiers LLC , an Illinois ... pleased to announce that all Rabbit brand air purifiers are ... the west coast port strikes. This news comes just in ... , The port strikes, which have caused significant ... economic growth by as much as 1%, have hindered the ...
(Date:3/3/2015)... Daylight Savings Time may lead to your kids ... for parents. , Parents and their children may feel a ... they set their clocks forward one hour for Daylight Savings ... one hour earlier -- you will have already lost one ... about “sleep hygiene” for their kids and teens this week, ...
(Date:3/3/2015)... 03, 2015 Topical BioMedics, Inc., announces its ... streamed live on Tuesday, March 10th, 12pm – 1pm and ... and accessible 24/7. , The Pain Management ... for the March 10th workshop is “Opioid Addiction: An ... the U.S. represents 5% of the world’s population, yet consumers ...
Breaking Medicine News(10 mins):Health News:1% For the Planet Asks Consumers to “Know Your Source” 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 4Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 2Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 3Health News:Don’t Let Daylight Savings Disrupt Your Child’s Sleep 2Health News:Topical BioMedics Hosts March Pain Management Webinar 2Health News:Topical BioMedics Hosts March Pain Management Webinar 3Health News:Topical BioMedics Hosts March Pain Management Webinar 4Health News:Topical BioMedics Hosts March Pain Management Webinar 5
(Date:3/3/2015)... Mass. , March 3, 2015 Boston Scientific ... Charles J. Dockendorff and Stephen P. MacMillan ... Two current members of the board, Uwe E. Reinhardt ... for re-election at the company,s annual meeting of stockholders in ... was formerly the executive vice president and chief financial officer ...
(Date:3/3/2015)... LOUISVILLE, Ky. , March 3, 2015 ... Louisville,s greatest leaders in aesthetics. In ... successful Brownsboro Plastic and Hand Surgery practice, Dr. Cummins ... Louisville Tattoo Removal clinic . Dr. Cummins performs ... "I founded Louisville Tattoo Removal in order ...
(Date:3/3/2015)... 2015 /CNW/ - The issue: ... being injected at Art Nails Ltd., located at 751 Helmcken St., ... as it contained no labelling. All products administered by injection in ... and must have approved labelling. The store ... consumers. Potential risks associated with injecting an unauthorized version of a ...
Breaking Medicine Technology:Boston Scientific Elects Charles J. Dockendorff And Stephen P. MacMillan To Board Of Directors 2Surgeon Owned And Operated Louisville Tattoo Removal Offers Astanza Duality Laser Treatments 2Advisory - Health product seized from Art Nails in Vancouver 2
Cached News: