The $60 million, 5-year ADNI study is the most comprehensive effort to date to identify brain and other biological changes associated with memory decline. The project was begun by the National Institute on Aging (NIA) and is supported by more than a dozen other federal agencies and private-sector companies and organizations. Investigators at 58 local study sites across the U.S. and Canada will be asking people ages 55 to 90 to become a part of this landmark research.
"We encourage people to participate in this important study because it will help us to identify needed biological markers of memory decline and Alzheimer's disease. These biomarkers could become comparable to the cholesterol measures now used as biomarkers for heart disease," says Susan Molchan, M.D., program director for the ADNI project at the NIA. "In addition, using what we learn from the brain scans and other tests, we hope to lessen the time and cost of testing drugs and to bring treatments to patients much sooner."
Scientists are looking for new ways to measure changes in the brain that occur with normal aging and with the progression of mild cognitive impairment (MCI), a subtle but measurable transitional state between the cognitive changes of normal aging and very early AD. People with MCI have memory impairments but otherwise function well and do not meet clinical criteria for dementia.
The ADNI researchers will employ serial magnetic resonance imaging (MRI); positron emission tomography (PET) s
Contact: Linda Joy
NIH/National Institute on Aging