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An alternative to prevent UC-associated colon cancer

urveillance lived longer than patients who underwent surveillance alone, and had a better quality of life. Patients who received statins and underwent surveillance once every 10 years had 96 percent of their cancer prevented the same proportion as those who underwent annual surveillance without statins.

"Ultimately, we found that statin chemoprevention of colon cancer is a promising strategy for the management of patients with chronic ulcerative colitis, and demonstrated the shortcomings of surveillance," says Rubenstein. "This study adds to a growing body of cost-effectiveness analyses that demonstrate a common principle: effective prevention with medicines is cost-effective compared to surveillance followed by just-in-time interventions, such as surgery."

Statins were originally developed to lower cholesterol, but also have been found to induce the programmed cell death of colorectal cancer cells in the laboratory, and observational studies suggest statins protect patients with ulcerative colitis from developing colon cancer, says study co-author Peter Higgins M.D., Ph.D., lecturer in the Division of Gastroenterology and Hepatology in the Department of Internal Medicine at the U-M Medical School.

"The results of our study are preliminary. More research is still needed to precisely determine the effectiveness of statins in the prevention of colon cancer, the accuracy of colonoscopy in the detection of pre-cancerous changes, and the quality of life of people with ulcerative colitis following a colectomy," says Higgins. "However, this study does prove the principle that chemoprevention is an effective strategy for the prevention of ulcerative colitis-associated colon cancer. If we can prove that medications like statins are an effective means to prevent cancer at a reasonable cost, chemotherapy may be the best alternative to frequent colonoscopy in patients with ulcerative colitis."

In addition to Rubenstein and Higgins, the study w
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16-May-2005


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