HOME >> MEDICINE >> NEWS
Animal BiP levels determine amount of recovery sleep needed following prolonged wakefulness

WESTCHESTER, Ill. -- Microarray studies have identified numerous genes that change in response to prolonged wakefulness. Determining which transcriptional changes translate into protein changes that are critical for recovery during sleep loss, however, can be challenging. Immunoglobulin binding protein (BiP), a key indicator of endoplasmic reticulum (ER) stress, is instrumental in determining the amount of recovery sleep following enforced wakefulness, according to a study published in the May 1st issue of the journal SLEEP.

The study, conducted by Nirinjini Naidoo, PhD, and colleagues at the University of Pennsylvania, focused on a Drosophila head and brain. The authors discovered that there are substantial increases in the molecular chaperone BiP in Drosophila head and brain after modest periods of sleep deprivation. These increases decline progressively during recovery sleep. However, even after 24 hours following sleep deprivation, there is still a small but significant increase in BiP.

According to Naidoo, changes in BiP levels also affect the amount of recovery sleep following sleep deprivation, although the precise mechanism by which this occurs remain to be elucidated.

"Acute sleep deprivation leads to cellular stress and possibly to low level brain injury, said Naidoo. Activation of the unfolded protein response is one protective mechanism against such injury. If protective mechanisms, such as the unfolded protein response, are attenuated, then following sleep deprivation, animals need to sleep more to recover."


'"/>

Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
1-May-2007


Page: 1

Related medicine news :

1. Animal study leading to new treatments for hemorrhagic shock and uncontrolled abdominal hemorrhage
2. Animal study identifies promising new target for brain tumor therapy
3. Animal studies suggest vegetables may reduce hardening of arteries
4. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
5. Animal research suggests perimenopause is a critical time for womens health
6. Animal disease reports to be released at July 18 news conference at AVMA convention
7. Animal research suggests new treatment target for epilepsy
8. Animal model demonstrates course of epilepsy
9. Even low levels of weekly exercise drive down blood pressure
10. Low hospital staff levels increase infection rates
11. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders

Post Your Comments:
(Date:11/22/2014)... 22, 2014 Setria® Glutathione is ... approved it for use “as a therapeutically active ... within the Therapeutic Goods (Listing) Notice 2014 (No. ... Hakko’s Setria® Glutathione will be exclusivity distributed in ... sources and imports fine chemicals to Australian manufacturers. ...
(Date:11/22/2014)... PITTSBURGH, PA (PRWEB) November 22, 2014 ... about the pain caused by the machine," said an ... injury, she had to go back a second time ... my invention idea." , She developed the patent-pending MAMO ... for breast cancer. The design saves the patient from ...
(Date:11/22/2014)... Lipitor lawsuits ( http://www.lipitorlawsuitcenter.com/ ) that ... developed Type 2 diabetes due to its use continue ... underway in U.S. District Court, District of South Carolina, ... litigation will convene its next Status Conference on December ... Counsel for Plaintiffs and Defendants to meet and confer, ...
(Date:11/22/2014)... November 22, 2014 The Sports Conflict ... Roy Baroff to its team of conflict resolution professionals. ... player, coach, and referee. He has over 30 years experience ... beyond. , “I'm very excited to connect with SCI and ... related interests to a program with a complete sports focus,” ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Wright & ... AndroGel side-effects lawsuits have been scheduled between October ... Northern District of Illinois. U.S. District Judge Matthew F. ... a Case Management Order (CMO) on November 6, 2014 ... for attorneys to submit documents and other activities in ...
Breaking Medicine News(10 mins):Health News:Setria® Glutathione Now Available in Australia 2Health News:Setria® Glutathione Now Available in Australia 3Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3Health News:SCI Announces New Team Member Roy Baroff 2Health News:SCI Announces New Team Member Roy Baroff 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 2Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 3Health News:First Bellwether Trials Scheduled In AndroGel Side-Effects Lawsuits Reports Wright & Schulte LLC 4
(Date:11/22/2014)... 2014 Many power shifts are occurring ... of patients in the biopharmaceutical market is impacting ... than ever, understanding how to effectively acquire, convert, ... essential. According to recent research ... spent about two-thirds of their patient-focused dollars on ...
(Date:11/21/2014)... Nov. 21, 2014 In September 2014, the ... carried out a new product development plan that started ... "limited edition" lab coat , aptly named "Vera ... surgery in the world. The new women,s designer lab ... with a sleek envelope collar, vertical princess and high ...
(Date:11/21/2014)... , Nov. 21, 2014  PTC Therapeutics, Inc. (NASDAQ: ... 2014 Legend of Technology Award for Vision, Innovation, and Leadership ... Chief Executive Officer. This award recognizes an individual who has ... New Jersey for several decades. ... Award," stated Stuart Peltz , Ph.D., CEO of PTC ...
Breaking Medicine Technology:New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 2PTC Therapeutics Announces CEO, Dr. Stuart Peltz Recipient of The New Jersey Technology Council's 2014 Legend of Technology Award 3
Cached News: