HOME >> MEDICINE >> NEWS
Animal BiP levels determine amount of recovery sleep needed following prolonged wakefulness

WESTCHESTER, Ill. -- Microarray studies have identified numerous genes that change in response to prolonged wakefulness. Determining which transcriptional changes translate into protein changes that are critical for recovery during sleep loss, however, can be challenging. Immunoglobulin binding protein (BiP), a key indicator of endoplasmic reticulum (ER) stress, is instrumental in determining the amount of recovery sleep following enforced wakefulness, according to a study published in the May 1st issue of the journal SLEEP.

The study, conducted by Nirinjini Naidoo, PhD, and colleagues at the University of Pennsylvania, focused on a Drosophila head and brain. The authors discovered that there are substantial increases in the molecular chaperone BiP in Drosophila head and brain after modest periods of sleep deprivation. These increases decline progressively during recovery sleep. However, even after 24 hours following sleep deprivation, there is still a small but significant increase in BiP.

According to Naidoo, changes in BiP levels also affect the amount of recovery sleep following sleep deprivation, although the precise mechanism by which this occurs remain to be elucidated.

"Acute sleep deprivation leads to cellular stress and possibly to low level brain injury, said Naidoo. Activation of the unfolded protein response is one protective mechanism against such injury. If protective mechanisms, such as the unfolded protein response, are attenuated, then following sleep deprivation, animals need to sleep more to recover."


'"/>

Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
1-May-2007


Page: 1

Related medicine news :

1. Animal study leading to new treatments for hemorrhagic shock and uncontrolled abdominal hemorrhage
2. Animal study identifies promising new target for brain tumor therapy
3. Animal studies suggest vegetables may reduce hardening of arteries
4. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
5. Animal research suggests perimenopause is a critical time for womens health
6. Animal disease reports to be released at July 18 news conference at AVMA convention
7. Animal research suggests new treatment target for epilepsy
8. Animal model demonstrates course of epilepsy
9. Even low levels of weekly exercise drive down blood pressure
10. Low hospital staff levels increase infection rates
11. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2017)... ... 20, 2017 , ... “I Forgive You”: a fine examination of how God handles sin, ... creation of published author, Stephen Miller, who, for over ten long years has been waiting ... Born in Trinidad and Tobago, he has been serving the Lord for over twenty years, ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Land of More and More”: a ... world hunger, and shares the simple and achievable answer. “The Land of More and ... the Fairview Missionary Church in Angola, Indiana where he works with the children’s ministry ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... and facility enhancement of their 503A compounding pharmacy located in Ocala, Florida. ... of physicians and patients throughout the United States for high-quality human anti-aging ...
(Date:1/19/2017)... ... January 19, 2017 , ... Remote Medical Technologies ... impressive transportable capabilities with their iMedHD2™ Portable Teleultrasound System. Compatible ... technology that delivers HD, dynamic, streaming ultrasound images and video to one or ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... ... announced it recently provided a new $11,250,000 senior credit facility to Sunrise, Florida-based ... MB credit facility were used to facilitate a recapitalization of MedPro led by ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... Report Details ... Alzheimer,s Disease Therapeutics and ... our new study reveals trends, R&D progress, and predicted ... the Alzheimer,s disease therapeutics and diagnostics market. Our new ... - How is the Alzheimer,s disease therapeutics and diagnostics ...
(Date:1/19/2017)... BOSTON , Jan. 19, 2017  Stealth BioTherapeutics ... therapeutics to treat mitochondrial dysfunction, today announced new additions ... , M.D., as Chief Medical Officer, and Daniel ... Stealth announced that Jim Carr , Pharm.D. has ... "We are pleased to welcome Doug and Daniel ...
(Date:1/19/2017)... 19, 2017 Accuray Incorporated (Nasdaq: ... Systems continue to set the bar for excellence in ... overall user satisfaction rating among radiation treatment delivery systems ... Buyline Market Intelligence Briefing™. The most recent ratings trend ... among industry peers for 11 of the past 12 ...
Breaking Medicine Technology:
Cached News: