HOME >> MEDICINE >> NEWS
Animal BiP levels determine amount of recovery sleep needed following prolonged wakefulness

WESTCHESTER, Ill. -- Microarray studies have identified numerous genes that change in response to prolonged wakefulness. Determining which transcriptional changes translate into protein changes that are critical for recovery during sleep loss, however, can be challenging. Immunoglobulin binding protein (BiP), a key indicator of endoplasmic reticulum (ER) stress, is instrumental in determining the amount of recovery sleep following enforced wakefulness, according to a study published in the May 1st issue of the journal SLEEP.

The study, conducted by Nirinjini Naidoo, PhD, and colleagues at the University of Pennsylvania, focused on a Drosophila head and brain. The authors discovered that there are substantial increases in the molecular chaperone BiP in Drosophila head and brain after modest periods of sleep deprivation. These increases decline progressively during recovery sleep. However, even after 24 hours following sleep deprivation, there is still a small but significant increase in BiP.

According to Naidoo, changes in BiP levels also affect the amount of recovery sleep following sleep deprivation, although the precise mechanism by which this occurs remain to be elucidated.

"Acute sleep deprivation leads to cellular stress and possibly to low level brain injury, said Naidoo. Activation of the unfolded protein response is one protective mechanism against such injury. If protective mechanisms, such as the unfolded protein response, are attenuated, then following sleep deprivation, animals need to sleep more to recover."


'"/>

Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
1-May-2007


Page: 1

Related medicine news :

1. Animal study leading to new treatments for hemorrhagic shock and uncontrolled abdominal hemorrhage
2. Animal study identifies promising new target for brain tumor therapy
3. Animal studies suggest vegetables may reduce hardening of arteries
4. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
5. Animal research suggests perimenopause is a critical time for womens health
6. Animal disease reports to be released at July 18 news conference at AVMA convention
7. Animal research suggests new treatment target for epilepsy
8. Animal model demonstrates course of epilepsy
9. Even low levels of weekly exercise drive down blood pressure
10. Low hospital staff levels increase infection rates
11. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders

Post Your Comments:
(Date:3/31/2015)... March 31, 2015 Dr. Parsa Mohebi, founder of ... transplant surgeons on the forefront of using beard hair ... thought of, as a novelty has now become an absolute option ... their hairlines. “I really do believe that beard to scalp hair ... if their donor area isn’t as dense as we would like ...
(Date:3/31/2015)... 31, 2015 Karen A. Daley, Ph.D. ... Rivier University’s Commencement ceremony on May 9, ... letters in recognition of her eminent career as a ... a front-line caregiver and senior staff nurse at Brigham ... advancing to leadership roles, including President of the American ...
(Date:3/31/2015)... 2015 Medical DNA Labs, LLC, An ... criteria for Laboratory Accreditation by COLA, a national healthcare ... that apply rigid standards of quality in day-to-day operations, ... and pass a rigorous on-site laboratory survey. Medical ... result of a long-term commitment to provide quality service ...
(Date:3/31/2015)... On March 26, 2015, Vogue Magazine UK, ... Slope?” provides a look into the trend of young women ... laser treatments . The article suggests that celebrity endorsements (Beyoncé ... as Kim Kardashian and Kylie Jenner are the drivers behind ... as significant influences on the self-esteem of teenagers. (see: goo.gl/NmaB4q) ...
(Date:3/31/2015)... 2015 Dr. St. Ledger recently returned from ... Dental Education. Here, he participated in the Worn Dentition ... a greater predictability in cases of severely worn teeth, as ... wear, and the correlation to GERD and Sleep Apnea. ... Spear Education. After the workshop he attended, he mentored ...
Breaking Medicine News(10 mins):Health News:Is Beard to Scalp Hair Transplant the Future? 2Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 2Health News:Rivier University to recognize nurse leader, educator and safety advocate at 80th Commencement on May 9th 3Health News:Local Medical DNA Labs, LLC. Recognized for Quality Laboratory Services 2Health News:Cosmetic Surgery: Does Social Media Pressure Young Girls to Get Botox and Fillers? 2Health News:The dentists at Upper Montclair Dental Associates are happy to announce exciting new happenings at their practice. 2
(Date:3/31/2015)... According to a new ... Market (Chromatography, Electrophoresis, DNA Sequencer, PCR, Microplate Reader, Robotics, ... Centrifuge) - Global Forecast to 2019", published by ... Market is expected to reach $48.84 Billion by ... 2019. Browse   9 ...
(Date:3/31/2015)... ALTO, Calif. , March 31, 2015  Frequentz ... visibility, has released a white paper to help the ... the 2013 Drug Supply Chain Security Act (DSCSA). The ... various stages of the GS1 EPCIS Standard(s) ... detailed outlook on the product tracing requirements that need ...
(Date:3/31/2015)... March 31, 2015  SCILEX Pharmaceuticals, Inc., a company ... on the treatment of pain, today announced that ITOCHU ... ), a member of ITOCHU Corporation ( Tokyo ... leading sogo shosha (general trading companies) in ... SCILEX.  ICF has worked closely with SCILEX as an ...
Breaking Medicine Technology:Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 2Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 3Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 4Life Science and Chemical Instrumentation Market Worth $48.84 Billion by 2019 5Frequentz Releases White Paper Addressing DSCSA's Current & Future Impact 2Frequentz Releases White Paper Addressing DSCSA's Current & Future Impact 3SCILEX Pharmaceuticals Announces Strategic Investment By ITOCHU CHEMICAL FRONTIER Corporation 2
Cached News: