HOME >> MEDICINE >> NEWS
Animal BiP levels determine amount of recovery sleep needed following prolonged wakefulness

WESTCHESTER, Ill. -- Microarray studies have identified numerous genes that change in response to prolonged wakefulness. Determining which transcriptional changes translate into protein changes that are critical for recovery during sleep loss, however, can be challenging. Immunoglobulin binding protein (BiP), a key indicator of endoplasmic reticulum (ER) stress, is instrumental in determining the amount of recovery sleep following enforced wakefulness, according to a study published in the May 1st issue of the journal SLEEP.

The study, conducted by Nirinjini Naidoo, PhD, and colleagues at the University of Pennsylvania, focused on a Drosophila head and brain. The authors discovered that there are substantial increases in the molecular chaperone BiP in Drosophila head and brain after modest periods of sleep deprivation. These increases decline progressively during recovery sleep. However, even after 24 hours following sleep deprivation, there is still a small but significant increase in BiP.

According to Naidoo, changes in BiP levels also affect the amount of recovery sleep following sleep deprivation, although the precise mechanism by which this occurs remain to be elucidated.

"Acute sleep deprivation leads to cellular stress and possibly to low level brain injury, said Naidoo. Activation of the unfolded protein response is one protective mechanism against such injury. If protective mechanisms, such as the unfolded protein response, are attenuated, then following sleep deprivation, animals need to sleep more to recover."


'"/>

Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
1-May-2007


Page: 1

Related medicine news :

1. Animal study leading to new treatments for hemorrhagic shock and uncontrolled abdominal hemorrhage
2. Animal study identifies promising new target for brain tumor therapy
3. Animal studies suggest vegetables may reduce hardening of arteries
4. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
5. Animal research suggests perimenopause is a critical time for womens health
6. Animal disease reports to be released at July 18 news conference at AVMA convention
7. Animal research suggests new treatment target for epilepsy
8. Animal model demonstrates course of epilepsy
9. Even low levels of weekly exercise drive down blood pressure
10. Low hospital staff levels increase infection rates
11. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders

Post Your Comments:
(Date:7/2/2015)... ... July 02, 2015 , ... “ LIFX ” was featured on NewsWatch ... products available to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, ... versatile smart light bulbs on the market. , According to the U.S. Department of ...
(Date:7/2/2015)... PEACHTREE CITY, GA (PRWEB) , ... July 02, ... ... or field sporting the newest shades of the SIGVARIS PERFORMANCE SOCKS. Since the ... physicians, fitness experts and athletic trainers. Their significant popularity has inspired four new, ...
(Date:7/2/2015)... ... , ... Six months ahead of his 80th birthday, Don Stevenson has reached ... for the Pulmonary Hypertension Association (PHA). Stevenson began the walk in Washington State ... mid-September. He left Glasgow, Mont. yesterday morning and is making his way to Wolf ...
(Date:7/2/2015)... Diego, CA (PRWEB) , ... July 02, 2015 , ... ... and a passion for social fitness. Built to function as a lifestyle community, Active ... giving them the opportunity to network, meet, and participate in discussions or group events. ...
(Date:7/2/2015)... ... July 02, 2015 , ... ... - pipeline review 2015” provides comprehensive information on the pipeline products with ... on negative pressure wound therapy (NPWT) with 22 market data tables and ...
Breaking Medicine News(10 mins):Health News:The Most Versatile Smart Light Bulbs were featured on NewsWatch Television 2Health News:SIGVARIS is Sporting Four Brand New Colors in the Popular PERFORMANCE SOCK Product Line 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 2Health News:79-Year-old ‘Pacing Parson’ Passes 1,000-Mile Mark in Cross-Country Walk for Pulmonary Hypertension Association 3Health News:ActiveBunch.com Launches as a Social Community for People with Active Lifestyles 2Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 2Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 3Health News:Negative Pressure Wound Therapy (System, Wound Care, Tissue Cooling NPWT) Pipeline Review 2015 Market Research Report Available at RnRMarketResearch.com 4
(Date:7/2/2015)...   , July 2, 2015 BGI ... Hong Kong has been accredited ... Kong facility is the first clinical next-generation-sequencing laboratory to ... , meeting the highest standard in clinical laboratory practices. Complementary ... 11 compliant laboratory process, and multiple ISO certifications, the ...
(Date:7/2/2015)...   Wilson Therapeutics AB , a privately-held biopharmaceutical ... its board of directors. The appointment was approved by ... 30. "We are delighted to welcome Hans ... , CEO of Wilson Therapeutics. "Hans brings significant global ... to his contributions to the Company." Hans ...
(Date:7/1/2015)... 1, 2015 The Coalition of State ... and regional professional rheumatology societies, today released the ... explored perceptions of biosimilars and the potential impact ... Biosimilars are medicines that are highly similar, ... notably different from generic medications in that it ...
Breaking Medicine Technology:BGI Receives Accreditation from the College of American Pathologists (CAP) 2Wilson Therapeutics Appoints Hans Schikan to its Board of Directors 2Survey Of Rheumatologists Nationwide Regarding Biosimilars Highlights Need For More Robust FDA Standards 2
Cached News: