HOME >> MEDICINE >> NEWS
Animal BiP levels determine amount of recovery sleep needed following prolonged wakefulness

WESTCHESTER, Ill. -- Microarray studies have identified numerous genes that change in response to prolonged wakefulness. Determining which transcriptional changes translate into protein changes that are critical for recovery during sleep loss, however, can be challenging. Immunoglobulin binding protein (BiP), a key indicator of endoplasmic reticulum (ER) stress, is instrumental in determining the amount of recovery sleep following enforced wakefulness, according to a study published in the May 1st issue of the journal SLEEP.

The study, conducted by Nirinjini Naidoo, PhD, and colleagues at the University of Pennsylvania, focused on a Drosophila head and brain. The authors discovered that there are substantial increases in the molecular chaperone BiP in Drosophila head and brain after modest periods of sleep deprivation. These increases decline progressively during recovery sleep. However, even after 24 hours following sleep deprivation, there is still a small but significant increase in BiP.

According to Naidoo, changes in BiP levels also affect the amount of recovery sleep following sleep deprivation, although the precise mechanism by which this occurs remain to be elucidated.

"Acute sleep deprivation leads to cellular stress and possibly to low level brain injury, said Naidoo. Activation of the unfolded protein response is one protective mechanism against such injury. If protective mechanisms, such as the unfolded protein response, are attenuated, then following sleep deprivation, animals need to sleep more to recover."


'"/>

Contact: Jim Arcuri
jarcuri@aasmnet.org
708-492-0930
American Academy of Sleep Medicine
1-May-2007


Page: 1

Related medicine news :

1. Animal study leading to new treatments for hemorrhagic shock and uncontrolled abdominal hemorrhage
2. Animal study identifies promising new target for brain tumor therapy
3. Animal studies suggest vegetables may reduce hardening of arteries
4. Animal models show that anabolic steroids flip the adolescent brains switch for aggression
5. Animal research suggests perimenopause is a critical time for womens health
6. Animal disease reports to be released at July 18 news conference at AVMA convention
7. Animal research suggests new treatment target for epilepsy
8. Animal model demonstrates course of epilepsy
9. Even low levels of weekly exercise drive down blood pressure
10. Low hospital staff levels increase infection rates
11. SCHIP funding levels too low ACP tells Senate Finance Committee Leaders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/10/2019)... ... 2019 , ... AltMed Florida , one of the fastest growing Medical ... grand opening of its second MÜV™ Medical Cannabis Dispensary on the First Coast – ... Jacksonville Beach. , Located at Beach Plaza Shopping Center at the corner of Beach ...
(Date:10/8/2019)... ... 2019 , ... What unique insights can three former Surgeons General of the ... the nation? That question will be answered at ICAA 2019: Shaping the Future of ... event will take place October 10-12, 2019, at the Gaylord Palms Resort and Convention ...
(Date:10/8/2019)... ... October 08, 2019 , ... Drs. ... help patients with missing teeth restore their smiles with long-lasting dental implants ... relies on advanced i-CAT® 3D Cone Beam CT imaging, X-Guide™ software and Yomi® ...
(Date:10/8/2019)... ... October 08, 2019 , ... METAvivor Research and Support Inc., ... the launch of its Stage IV Stampede campaign. The campaign will commence with two ... that will include an advocacy boot camp, a march, a Die-In (hosted by partner ...
(Date:10/8/2019)... ... , ... On November 9, 2019, husband and wife dental team, Dr.’s Michael and Azita Mansouri, ... marks the ninth consecutive year that Mansouri Family Dental Care & Associates has ... event has always had a great turnout, serving over 300 people in a single day ...
Breaking Medicine News(10 mins):
(Date:10/9/2019)... ... October 09, 2019 , ... The 11th annual ... Yoga Science and AMI Meditation for the relief and prevention of physician burnout. ... October 22-26, 2019 at the Cranwell Resort and Spa in Lenox, Massachusetts, is ...
(Date:10/8/2019)... ... ... Help.org, a trusted online resource for individuals who struggle with addiction and their loved ... guide recognizes the top 17 rehab facilities based on cost, treatment options, location, accompanying ... the leading cause of death among people under age 50. In Boston, deaths related ...
(Date:10/8/2019)... ... October 08, 2019 , ... Dr. ... raise awareness of their advanced dental and medical training to offer medically ... welcome patients with heart conditions, diabetes, and other systemic concerns for dental implants ...
Breaking Medicine Technology:
Cached News: