Blood loss due to severe internal injuries requires rapid action to prevent mortality. Using a swine model for severe hemorrhagic shock and uncontrolled abdominal hemorrhage, three methods of treatment were investigated. In a paper to be presented at the 2007 Society for Academic Emergency Medicine (SAEM) Annual Meeting, James Manning, MD, will show that Hemoglobin-Based Oxygen Carrier (HBOC)-201 resuscitation maintained survival longer than Hetastarch, and in particular, targeting a Mean Arterial Pressure (MAP) of 80 mm Hg was more favorable than a target MAP of 100 mm Hg.
HBOC-201 is expected to improve treatments in human trauma victims, particularly in pre-hospital or battlefield settings where blood is generally not available for transfusion. This product is in clinical trials abroad, and the U. S. Navy is seeking regulatory approval to initiate a trauma trial in the United States. Dr. Manning indicates that this product shows promise as a life-saving treatment for severe injuries with major blood loss.
The presentation is entitled Mesenteric Blood Flow During Hemoglobin-Based Oxygen Carrier (HBOC)-201 Fluid Resuscitation In A Swine Model Of Severe Hemorrhagic Shock And Uncontrolled Abdominal Hemorrhage by James E. Manning, MD, and Laurence Katz, MD, of the University of North Carolina at Chapel Hill. This paper will be presented at the 2007 SAEM Annual Meeting, May 16-19, 2007, Chicago, IL on Wednesday, May 16th, in the Plenary Session beginning at 1:00 PM in Sheraton 4 & 5 of the Sheraton Chicago Hotel & Towers. Abstracts of the papers presented are published in Volume 14, Issue 5S, the May 2007 supplement of the official journal of the SAEM, Academic Emergency Medicine.