HOME >> MEDICINE >> NEWS
Anti-inflammatory drug's potentially deadly side effect found to be rare

Scientists have completed an extensive study of more than 3,000 patients who received a promising anti-inflammatory drug, natalizumab, that was linked to three cases of a serious brain infection in large clinical trials halted in early 2005.

The new study found no new cases of progressive multifocal leukoencephalopathy (PML) and confirmed the three previously identified cases of PML associated with use of the drug. One fatal and one nonfatal case of PML occurred in a trial using natalizumab as a multiple sclerosis treatment; a second fatality happened in a trial that used the drug to treat patients with Crohn's disease, an inflammatory bowel disorder.

"Our analysis suggests about one in every1,000 people who took natalizumab contracted this disease; however, there weren't enough patients exposed to the drug to allow us to precisely estimate the risk, which could be as low as one in 5,000 or as high as one in 300," says senior author David Clifford, M.D., the Melba and Forest Seay Professor of Clinical Neuropharmacology in Neurology at Washington University School of Medicine in St. Louis.

The results of the study, along with two separate studies of natalizumab's effectiveness as an MS treatment, are published in this week's issue of The New England Journal of Medicine.

The brand name of natalizumab, which was jointly developed by Biogen and Elan Pharmaceuticals, is Tysabri. The drug is a monoclonal antibody that binds to inflammatory immune T cells and prevents them from crossing membranes that protect the brain and the central nervous system. Prior to the studies that were halted last year, earlier studies showed a 66 percent reduction in the rate of relapses in MS patients treated with the natalizumab, which has to be injected on a monthly basis.

Clifford predicts that his group's report and the other studies of natalizumab will be important elements in "lively" discussions to be held by the Food and Drug Administration reg
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
1-Mar-2006


Page: 1 2 3 4

Related medicine news :

1. Anti-inflammatory drug prevents liver cancer in at-risk liver patients
2. Anti-inflammatory drugs following hip replacement surgery could harm rather than help
3. Anti-inflammatory function of Alzheimers disease drugs revealed
4. A drugs brand name skews patient treatment choices
5. Chemical maps hint at drugs effects on schizophrenia
6. Study to test drugs potential to preserve insulin production in newly diagnosed type 1 diabetics
7. Trial demonstrates new drugs effectiveness against psoriasis
8. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
9. STAMP system can help professionals to identify potentially violent individuals
10. Women with breast cancer do not get potentially life-saving information, survey reveals
11. U-M study finds some prostate cancer patients potentially overtreated

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Anti inflammatory drug potentially deadly side effect found rare

(Date:7/22/2014)... says women are often in the dark. Historically, it was ... has shown that post-menopausal women are just as likely as ... be adequately diagnosed and treated. New research from Western University ... Clinical Pharmacology brings to light a genetic basis for ... are more prone to heart disease. , The study, led ...
(Date:7/22/2014)... July 22, 2014 As reported on July ... caller request to name her favorite beauty products, “ Botox ... to say that “ Botox has changed my life” ... makeup chair preparing for her various, daily appearances. “Suddenly ... Ms. Ripa (see: goo.gl/shmTQM). , “I think that Kelly Ripa’s ...
(Date:7/22/2014)... New guidelines on cholesterol treatment and cardiovascular risk assessment ... of dying from atherosclerotic cardiovascular disease or of having ... a similar risk profile (based on age, smoking history, ... this finding for when and how aggressively to treat ... Journal of Men,s Health , a peer-reviewed publication from ...
(Date:7/22/2014)... Ticket Down is a reliable source for ... Field in Landover, MD. There has never been a better ... soccer. After the success of the American national soccer team at ... well. One way that fans of the world’s sport will be ... 2014 Guinness International Champions Cup. The tournament will kick off on ...
(Date:7/22/2014)... The park is the heart of ... Homeowners Association, Inc., made a recent investment in ... the purchase of playground equipment from American Parks Company™. ... Miami Florida, and is a 475-unit community that was ... landscape has created a tropical paradise with lush shade ...
Breaking Medicine News(10 mins):Health News:Gene variant identified as a heart disease risk factor for women 2Health News:Celebrity Botox: Kelly Ripa Confesses to Getting Botox Injections 2Health News:Manchester United vs. Inter Milan Tickets Fedex Field Landover: Ticket Down Slashes Ticket Prices for Inter Milan ManU International Champions Cup Match in Washington, DC 2Health News:Manchester United vs. Inter Milan Tickets Fedex Field Landover: Ticket Down Slashes Ticket Prices for Inter Milan ManU International Champions Cup Match in Washington, DC 3Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 2Health News:Fun in the Florida Sun: Kendalltown Homeowners Association Inc. Expands Outdoor Recreation with American Parks Company™ 3
(Date:7/22/2014)... England , July 22, 2014 Elekta ... announced today that The Christie NHS Foundation Trust ( ... will join a consortium whose mission is to develop ... (MRI) guided radiation therapy system. Such a system would, ... visualization of cancer targets. "The Christie ...
(Date:7/22/2014)... 2014 Galmed Pharmaceuticals Ltd. (Nasdaq: ... the development and commercialization of a once-daily, oral therapy ... announced today that the U.S. Food and Drug Administration, ... IND, application.  Such clearance will permit Galmed to conduct ... the United States for the treatment ...
(Date:7/22/2014)... July 22, 2014 The steady decline ... spreading to previously rep-friendly specialties, according to the ... marketing consulting firm ZS Associates.      ... U.S. pharmaceutical sales teams. The report examines how ... with the pharmaceutical sales reps who visit their ...
Breaking Medicine Technology:The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 2The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 3The Christie Hospital joins Elekta and Philips research consortium to develop MRI-guided radiation therapy system for cancer treatment 4Galmed Announces FDA Clearance of IND of Armachol for the Treatment of Fatty Liver Disorders 2Galmed Announces FDA Clearance of IND of Armachol for the Treatment of Fatty Liver Disorders 3Galmed Announces FDA Clearance of IND of Armachol for the Treatment of Fatty Liver Disorders 4Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 2Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 3Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 4Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 5
Cached News: