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Anti-thrombotic medication significantly reduces risk of death for heart attack patients

standard approaches to antithrombotic therapy in patients with STEMI in preventing death or reinfarction (additional heart attack) at 30 days. These outcomes were also assessed at 9 days and at study end (minimum of 3 and maximum of 6 months). The study included 12,092 patients with STEMI from 447 hospitals in 41 countries who were randomized to receive fondaparinux 2.5 mg once daily for up to 8 days or usual care (placebo in those in whom UFH is not indicated or UFH for up to 48 hours followed by placebo for up to 8 days in patients with STEMI).

The researchers found that death or reinfarction at 30 days was significantly reduced from 11.2 percent of 6,056 patients in the control group to 9.7 percent of 6,036 patients in the fondaparinux group, a risk reduction of 14 percent. These benefits were observed at 9 days (8.9 percent) placebo vs. (7.4 percent) fondaparinux, a 17 percent risk reduction; and at study end (14.8 percent) placebo vs. (13.4 percent) fondaparinux, a 12 percent reduction. Risk of death was significantly reduced throughout the study. However, there was no benefit in those undergoing primary PCI. There was a tendency to fewer severe bleeding events in the fondaparinux group.

"In summary, fondaparinux reduces mortality and reinfarction early, and this benefit persists long term," the authors write. " results from OASIS-6 confirm the value and safety of fondaparinux as a simple and widely applicable antithrombotic therapy in a broad group of patients with acute coronary syndrome."


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Contact: Veronica McGuire
905-525-9140
JAMA and Archives Journals
14-Mar-2006


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