HOME >> MEDICINE >> NEWS
Antibiotic treatment successful against elephantiasis

A single course of one antibiotic can successfully treat elephantiasis (filariasis)--a parasitic worm disease that is one of the most common causes of global disability, concludes a study published in this week's issue of THE LANCET.

Bancroftian filariasis is a disease characterised by severe and debilitating swelling of the limbs. The search for compounds active against the causative organism, Wuchereria bancrofti adult worms, has so far failed to deliver a radical curative treatment. The antifilarial drugs currently used, diethylcarbamazine and ivermectin, are predominantly active against the larval offspring of the parasite. These treatments form the basis of global programmes used to eliminate lymphatic filariasis. However, drugs with adult worm activity could greatly improve the prospects of programme closure.

Mark Taylor (Liverpool School of Tropical Medicine, Liverpool, UK) and colleagues tested whether treatment against Wolbachia--a bacterium the adult worms are dependent on--could be effective for filariasis. They recruited 72 men infected with W bancrofti from Kimang'a village, Pangani, Tanzania, aged 1568 years. Half were assigned to placebo and half to an 8-week course of the antibiotic doxycycline. They found that doxycycline treatment resulted in almost complete elimination of adult worms 14 months after treatment and a sustained loss of larval offspring from at least 8 to 14 months after treatment.

Dr Taylor concludes: "In our study, an 8-week course of doxycycline against W bancrofti induced both sustained reductions in the larval offspring and, most notably, the adult worm activity. This is especially important since the adult worms cause the disease pathology in lymphatic filariasis and no safe, effective treatment against adult worms existsHowever, an 8-week course of doxycycline treatment is not applicable to mass treatment strategies because of both the logistical difficulties of delivering long-term treatments and doxyc
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
1-212-633-3810
Lancet
16-Jun-2005


Page: 1 2

Related medicine news :

1. Antibiotic ear drops favored over popular oral antibiotics for ear infections
2. Antibiotic proves successful in tackling symptoms of acute asthma
3. Antibiotic not sufficient for serious eye infection in communities with high disease prevalence
4. Antibiotic eardrops better than pills at treating middle ear infections
5. Antibiotics do not prevent recurrent myocardial infarcts in subjects with periodontitis
6. Antibiotics appear to have little benefit for uncomplicated lower respiratory tract infections
7. Antibiotic treatment not necessary for majority of children with conjunctivitis
8. Antibiotic might fight HIV-induced neurological problems
9. Spot on treatment for acne
10. New treatment boosts muscle function in myasthenia gravis
11. New treatment effective in counteracting cocaine-induced symptoms

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand Rapids-based ... and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be honored ... 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection Hotel, ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a ... targeted tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)...  Consumer reviews on the independent review site Consumer Affairs ... company for hearing aids, ranking it higher than Miracle Ear ... ... For Hearing Aids ... online store that provides high performance, state-of-the-art, German-engineered hearing aids directly ...
Breaking Medicine Technology:
Cached News: