Antidepressants may be associated with modestly increased risk of suicidality in children

An analysis of data from 24 clinical trials suggests that antidepressant medications may be linked to a modest increase in the risk of suicidal thoughts and behaviors in children, according to an article in the March issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

For decades, some physicians have suspected that patients' risk of suicidality (suicidal thoughts and behavior) increased when pediatric patients first began taking antidepressants, according to background information in the article. Research indicates that there is no such association in adults. In 2003, a report submitted to the Food and Drug Administration (FDA) suggested a link between the antidepressant paroxetine and suicidality in pediatric patients. The FDA then requested pediatric data from the manufacturers of eight other antidepressant drugs, the authors report.

Tarek A. Hammad, M.D., Ph.D., and colleagues at the FDA performed a meta-analysis of data from 23 short-term clinical trials received in response to the request, as well as one trial funded by the National Institute of Mental Health (NIMH). The 24 studies included 4,582 pediatric patients taking one of nine antidepressant medications for depression, anxiety or other psychiatric disorder.

No children committed suicide in any of the trials. Although the NIMH-funded trial was the only individual trial to show a significant increase in suicidality among children taking antidepressants, the analysis of all the trials together showed a higher risk of suicidal ideation and behavior for children taking the drugs compared with those who were not. "When considering 100 treated patients, we might expect one to three patients to have an increase in suicidality beyond the risk that occurs with depression itself owing to short-term treatment with an antidepressant," the authors write.

The FDA now requires warnings regarding the risk of suicidality in children on antidepressant labeling a

Contact: Susan Cruzan
JAMA and Archives Journals

Page: 1 2

Related medicine news :

1. Antidepressants safe for children and adolescents
2. Antidepressants improve post-stroke thinking outside the box
3. CIHR-funded research: Antidepressants help men decrease alcohol consumption, but not women
4. Antidepressants associated with increased risk for suicide attempts, decreased risk for death
5. Antidepressants might reduce risk of colorectal cancer
6. Antidepressants and electroconvulsive therapy are the best treatment options for depression
7. Antidepressants should be first-line approach for nerve tissue pain
8. Antidepressants may lower risk of recurrent heart attack in depressed heart attack patients
9. Antidepressants lessen risk of heart attack, Stanford researcher says
10. Study, meta-analysis examine factors associated with death from heatstroke
11. Fluctuating eye pressure associated with visual field deterioration in glaucoma patients

Post Your Comments:
(Date:10/9/2015)... PA (PRWEB) , ... October 09, 2015 , ... "As ... of two inventors from Philadelphia, Pa. "They have to wear large diapers or pads. ... solutions." , They developed the TROUSAFE to absorb urine leaking from the tip of ...
(Date:10/9/2015)... Australia (PRWEB) , ... October 09, 2015 , ... ... in an upcoming episode of Innovations with Ed Begley Jr., airing 1st QT ... segment, Innovations will educate audiences on MMJ Phytotech Limited (MMJ) – a global ...
(Date:10/9/2015)... (PRWEB) , ... October 09, 2015 , ... Santa Rosa ... their partnership as MD Anderson prepares to go-live on the Epic platform in March ... for early 2016. Santa Rosa will execute the contract by supporting Scheduling Appointment Conversion ...
(Date:10/9/2015)... ... October 09, 2015 , ... Deadly, record-smashing rainfall has caused ... (CCCF) in Columbia, South Carolina. In response, the Foundation has established a national ... both short and long term. 100% of monies donated will go directly to ...
(Date:10/9/2015)... , ... October 09, 2015 , ... Most people assume ... with more vegetables and less meat. While noted T’ai Chi Master and integrative medicine ... and Yang” relationship between the two cuisines and that they potentially complement one another, ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... -- Eli Lilly and Company (NYSE: LLY ) today ... new jobs to its research and development presence at the ... York . --> ... a translational immuno-oncology hub and a Lilly "portal," which will ... cutting-edge drug discovery capabilities, including chemistry and lead optimization expertise. ...
(Date:10/9/2015)... , Schweiz, October 9, 2015 Der ... Dr.   Yutaka Kondo und Dr.   Junko Takita ...   2015 " geht an Dr.   Yutaka ... Der " JCA-Mauvernay Award   2015 ... Dr.   Junko Takita    ™ , das ...
(Date:10/8/2015)... HERTFORDSHIRE, England and PITTSBURGH ... MYL ), a leading global pharmaceutical company, will host ... th at 5:00 pm ET to review the ... plc (NYSE: PRGO ; TASE) through Mylan,s offer ... review a comprehensive presentation which outlines the compelling proposition ...
Breaking Medicine Technology:
Cached News: