HOME >> MEDICINE >> NEWS
Antioxidant may have adverse effects in head and neck cancer patients

Alpha-tocopherol supplementation may have unexpected adverse effects on the occurrence of second primary cancers and on cancer-free survival in patients with head and neck cancer, according to a new study in the April 6 issue of the Journal of the National Cancer Institute.

Studies have found an association between low dietary intake of antioxidants and an increased risk of cancer, but trials that have tested the cancer-preventive effects of antioxidant supplementation have had mixed results. Two of the most studied vitamins have been alpha-tocopherol (vitamin E) and beta-carotene, a precursor of vitamin A.

To determine whether antioxidant supplementation could reduce the risk of second primary cancers in head and neck cancer patients, Isabelle Bairati, M.D., Ph.D., of the Universit Laval in Qubec City, Qubec, and colleagues conducted a multicenter, double-blind, placebo-controlled, randomized trial among 540 patients with stage I or II head and neck cancer who had been treated with radiation therapy between 1994 and 2000. Participants received supplementation with alpha-tocopherol and beta-carotene or a placebo during radiation therapy and for the next 3 years. (Beta-carotene supplementation was discontinued about 1 year into the trial because results from a different large trial found an increased incidence of lung cancer among smokers receiving beta-carotene.) Participants were followed for a median of 52 months.

Compared with patients given a placebo, patients who received alpha-tocopherol supplements had a higher rate of developing a second primary cancer during the period of supplementation but a lower risk of a second primary cancer after supplementation ended. Overall, the proportion of participants free of a second primary cancer after 8 years of follow-up was similar in both groups of patients. The rate of having a recurrence of the head and neck cancer or a second primary cancer was also higher during supplementation among p
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
5-Apr-2005


Page: 1 2

Related medicine news :

1. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
2. Antioxidants may protect against tick-borne illness
3. Antioxidant selenium offers no heart-disease protection
4. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
5. HIV and malaria combine to adversely affect pregnant women and their infants
6. Doctors extended duration work shifts are associated with medical errors and adverse events
7. Exposures to the insecticide chlorpyrifos in pregnancy adversely affect child development
8. Accountability after adverse medical events
9. Patients can report statins adverse effects on new web site
10. Research shows no direct association between anxiety symptoms and adverse pregnancy outcomes
11. Deployment to Iraq war associated with increased risk for adverse neuropsychological effects

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Antioxidant may have adverse effects head and neck cancer patients

(Date:7/2/2015)... ... ... sweetFrog Enterprises, LLC. is pleased to announce the opening of its newest ... Mississippi. The premium frozen yogurt chain was listed as #22 on the Inc. 500 ... Avenue, New Albany, MS 38652, will have a grand opening event on July 4, ...
(Date:7/2/2015)... ... ... Following the recent report by JAMA Internal Medicine published on June ... Becic emphatically declared a war on obesity in the United States. , "Obesity is ... understand the magnitude of this discovery. For that reason, I am declaring, along with ...
(Date:7/2/2015)... RI (PRWEB) , ... July 02, 2015 , ... Many ... safety in mind. That’s why Amica Insurance is sharing some tips to ... Commission (CPSC), approximately 230 people go to the emergency room daily with fireworks-related injuries ...
(Date:7/2/2015)... , ... July 02, 2015 , ... “ LIFX ” ... latest and coolest technology products available to consumers. Amanda Forstrom, a technology expert and ... bulbs are the most versatile smart light bulbs on the market. , According to ...
(Date:7/2/2015)... ... 2015 , ... Global leader and compression innovator, SIGVARIS North America, ... , For style that’s quick on its feet, men will love this fun new ... men everywhere because a simple change in socks can dramatically help improve overall leg ...
Breaking Medicine News(10 mins):Health News:sweetfrog Opens First Location in Mississippi 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 2Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 3Health News:Samir Becic's Health Fitness Revolution Declares War Against Obesity in America 4Health News:6 Fireworks Safety Tips from Amica Insurance 2Health News:The Most Versatile Smart Light Bulbs were featured on NewsWatch Television 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 2Health News:SIGVARIS Kicks Up Its Style for Men with the Launch of MIDTOWN MICROFIBER in a Dark Navy Stripe Pattern 3
(Date:7/2/2015)... July 2, 2015 Roche,s Bloodhound technology ... market segment in hematology testing, according to Kalorama ... recent unveiling of its Bloodhound digital cell imaging ... m 511 hematology analyzer – is notable ... enjoyed by current leader CellaVision, but also compete ...
(Date:7/2/2015)...   EVO Aesthetic Center and Wellness Spa ... aesthetics in Lakeway, Texas and ... Astanza Duality laser. The medical spa is focused on ... and laser procedures. Their addition of the Astanza Duality ... to their tattoo regret. "The large number ...
(Date:7/2/2015)... July 2, 2015   Decision Resources Group ... specialists identify less frequent dosing as the highest ... to the burden on both patients and providers ... factor (VEGF) injections, which are the current standard ... pegol, which is in development for dosing every ...
Breaking Medicine Technology:Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 2Kalorama: With Bloodhound, Roche Closes in on High-Growth Hematology Segment 3EVO Offers Advanced Laser Tattoo Removal With Astanza Duality In Lakeway, TX 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 2Retinal Specialists Indicate Strong Desire for DME Therapies Which Induce Greater Vision Gains or are Administered Less Frequently Than Currently Approved Anti-VEGF Therapies 3
Cached News: