HOME >> MEDICINE >> NEWS
Antipsychotic drug may block addiction, UIC researchers find

Researchers at the University of Illinois at Chicago have discovered that a long-approved oral antipsychotic drug can stop the addictive properties of opioid painkillers in mice.

The researchers injected a small dose (half a milligram) of trifluoperazine -- used in the treatment of mental diseases such as schizophrenia -- into laboratory mice hooked on morphine. After a few hours their addiction was gone, said Z. Jim Wang, assistant professor of pharmacology in the UIC College of Pharmacy.

This is the first time any study has shown the anti-addictive property of trifluoperazine, Wang said.

"From studies conducted in the 1970s and 1980s, we know that trifluoperazine inhibits calmodulin," Wang said, a molecule that is required for the activation of an enzyme called calcium/calmodulin-dependent protein kinase-2. "In previous studies we performed at UIC, we know that CaMK-2 plays an important role in the generation and maintenance of opioid tolerance," he said. Tolerance is a hallmark of drug dependence.

"Trifluoperazine targets this pathway, which then stops the addiction," Wang said. "When this occurs, you can still use a relatively low dose of the painkiller to achieve fairly good pain control and no drug dependence."

Opioids such as morphine are commonly used in pain management, but many patients are wary of taking them because of concerns over addiction or adverse side effects.

The study, which began early last year and was supported in part by grants from the National Institutes of Health and the American Foundation for Pharmaceutical Education, is published in the journal Neuroscience Letters. It is now available online and will be printed later this month.

Other researchers involved in the study were graduate student Lei Tang and post-doctoral researcher Pradeep Shukla, both of the UIC College of Pharmacy.


'"/>

Contact: Sam Hostettler
samhos@uic.edu
312-355-2522
University of Illinois at Chicago
8-Feb-2006


Page: 1

Related medicine news :

1. Antipsychotic drugs increase risk of death in older people with dementia
2. Antipsychotic drugs increase risk of death in older people with dementia
3. Antipsychotic medications used to treat Alzheimers patients found lacking
4. Antipsychotic treatment of dementia leads to small increase in risk of death
5. Antipsychotic drugs linked to increased risk of death for some elderly Alzheimers patients
6. Scientists train nano-building blocks to take on new shapes, as reported in Science
7. Future therapies for stroke may block cell death
8. Scavenger cells may have role blocking obesity, Stanford study shows
9. Computer scientist reveals the math and science behind blockbuster movies
10. First-degree fetal heart block may be reversible
11. MR angiography highly accurate in detecting blocked arteries

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... MESA, Calif. (PRWEB) , ... September 01, 2020 , ... ... the “safe side”, the Cohn Health Institute has taken this time to ... In celebration of its 30th Anniversary, the Cohn Health Institute will be relaunching its ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based ... to medical first responders across the United States. Since the start of the ... equipment (PPE) medical centers , hospitals , firefighters , and ...
(Date:8/31/2020)... LAWRENCEVILLE, Ga. (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic ... to examine our budgets and look for ways to trim the fat from our monthly ... stabilize your finances, but it’s also important that you have a financial safety net in ...
(Date:8/29/2020)... ... , ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, ... than become melancholic, however, he put together a final lecture in Carnegie Hall in ... a negative situation and turned it into something that inspired millions of people worldwide. ...
(Date:8/28/2020)... MIAMI (PRWEB) , ... August 28, 2020 , ... ... in Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor ... destroy airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Raheleh ... a unique perspective and approach. Armed with her qualifications from Ross University School ... her knowledge of the human body with the nation and world. With a ...
(Date:8/27/2020)... ... 2020 , ... The flu season is right round the corner and the risk of getting ... necessary measures before it begins to harbor its effects on us. Already with the sudden ... huge impact on our lives. Hence it has become even more relevant to keep oneself ...
(Date:8/27/2020)... MYERS, Fla. (PRWEB) , ... August 27, 2020 , ... ... Board of Directors. Dr. Friedman is an adult and pediatric neuro-oncologist who serves on ... University and as an educator at Duke University Medical School. , Internationally recognized, Dr. ...
Breaking Medicine Technology:
Cached News: