HOME >> MEDICINE >> NEWS
Antipsychotic drugs increase risk of death in older people with dementia

PHILADELPHIA, June 5, 2007 - A new study shows that use of antipsychotic drugs is associated with an early and sustained increase in risk of death when used to treat disruptive behavior of older adults with dementia.

The study suggests that both newer atypical antipsychotics and older conventional antipsychotics are associated with increased mortality. The highest risk appears to involve use of the older conventional drugs.

Antipsychotic drugs are approved for treating psychotic conditions such as schizophrenia and mania. But they are widely prescribed to manage behavioral symptoms of dementia, such as agitation, verbal or physical aggression and delusions, hallucinations or paranoia.

Our study adds to mounting concerns about the use of antipsychotic drugs in dementia, said Sudeep Gill, MD, MSc, a geriatric medicine specialist and the studys lead author.

The FDA and Health Canada both issued warnings in 2005 that use of newer atypical antipsychotics to treat elderly patients with dementia was associated with an increased risk of death. But Dr. Gill said, Previous trials have generally been very short and could not provide information about the long-term impact of antipsychotics on death. And relatively little information has been available on the harms associated with the older conventional or typical antipsychotics.

Investigators in the new study linked four administrative health care databases to look at health and death records of more than 27,000 people age 66 and older diagnosed with dementia between April 1, 1997, and March 31, 2002.

The investigators found:

  • Estimated mortality rate among study participants was high, especially in the long-term care setting.

  • Conventional antipsychotics were associated with higher risk for death than atypical antipsychotics, and atypical antipsychotics were associated with higher risk for death than no antipsychotic use.

'"/>

Contact: Susan Anderson
sanderson@acponline.org
215-351-2653
American College of Physicians
4-Jun-2007


Page: 1 2

Related medicine news :

1. Antipsychotic drugs increase risk of death in older people with dementia
2. Antipsychotic medications used to treat Alzheimers patients found lacking
3. Antipsychotic drug may block addiction, UIC researchers find
4. Antipsychotic treatment of dementia leads to small increase in risk of death
5. Antipsychotic drugs linked to increased risk of death for some elderly Alzheimers patients
6. UIC researchers to develop new drugs to fight bioterrorism
7. Statin drugs may delay progressive artery damage in children
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Experts call for urgent research into anti-epileptic drugs given to children
10. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
11. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical distributor ... first responders across the United States. Since the start of the global COVID-19 ... medical centers , hospitals , firefighters , and public ...
(Date:8/31/2020)... LAWRENCEVILLE, Ga. (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic ... to examine our budgets and look for ways to trim the fat from our monthly ... stabilize your finances, but it’s also important that you have a financial safety net in ...
(Date:8/29/2020)... (PRWEB) , ... August 29, 2020 , ... When professor ... perhaps with greater ease than most people would. Rather than become melancholic, however, he ... deep advice on achieving one’s dreams. Randy Pausch took a negative situation and turned ...
(Date:8/28/2020)... ... August 28, 2020 , ... Integrated Viral Protection (IVP ... Florida school to deploy its breakthrough Mobile Biodefense Indoor Air Protection System that is ... Classical Academy plans to fully reopen equipped with the filtration system on September 8th. ...
(Date:8/27/2020)... ... August 27, 2020 , ... Evolution ... Labs to provide their students with Suite360:Mental Health and Prevention, a program developed ... Abuse and Child Trafficking Prevention. , Florida schools and districts must provide their ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... ... Dr. Mark Surrey has been in practice for over 25 years. ... in the Department of OBGYN at UCLA’s David Geffen School of Medicine. , ... and is a Clinical Director of Fellowship Training for UCLA & Cedars Sinai Reproductive ...
(Date:8/27/2020)... ... August 27, 2020 , ... The flu season is right round the corner and ... equipped with all the necessary measures before it begins to harbor its effects on us. ... it is leaving a huge impact on our lives. Hence it has become even more ...
(Date:8/27/2020)... ... August 27, 2020 , ... The GHT Companies , a leading developer ... Feeding San Diego with a press conference at its manufacturing facility in ... check of $5,000.00+ representing an overall donation result exceeding $30,000 to Feeding San Diego, ...
Breaking Medicine Technology:
Cached News: