HOME >> MEDICINE >> NEWS
Antipsychotic drugs increase risk of death in older people with dementia

PHILADELPHIA, June 5, 2007 - A new study shows that use of antipsychotic drugs is associated with an early and sustained increase in risk of death when used to treat disruptive behavior of older adults with dementia.

The study suggests that both newer atypical antipsychotics and older conventional antipsychotics are associated with increased mortality. The highest risk appears to involve use of the older conventional drugs.

Antipsychotic drugs are approved for treating psychotic conditions such as schizophrenia and mania. But they are widely prescribed to manage behavioral symptoms of dementia, such as agitation, verbal or physical aggression and delusions, hallucinations or paranoia.

Our study adds to mounting concerns about the use of antipsychotic drugs in dementia, said Sudeep Gill, MD, MSc, a geriatric medicine specialist and the studys lead author.

The FDA and Health Canada both issued warnings in 2005 that use of newer atypical antipsychotics to treat elderly patients with dementia was associated with an increased risk of death. But Dr. Gill said, Previous trials have generally been very short and could not provide information about the long-term impact of antipsychotics on death. And relatively little information has been available on the harms associated with the older conventional or typical antipsychotics.

Investigators in the new study linked four administrative health care databases to look at health and death records of more than 27,000 people age 66 and older diagnosed with dementia between April 1, 1997, and March 31, 2002.

The investigators found:

  • Estimated mortality rate among study participants was high, especially in the long-term care setting.

  • Conventional antipsychotics were associated with higher risk for death than atypical antipsychotics, and atypical antipsychotics were associated with higher risk for death than no antipsychotic use.

'"/>

Contact: Susan Anderson
sanderson@acponline.org
215-351-2653
American College of Physicians
4-Jun-2007


Page: 1 2

Related medicine news :

1. Antipsychotic drugs increase risk of death in older people with dementia
2. Antipsychotic medications used to treat Alzheimers patients found lacking
3. Antipsychotic drug may block addiction, UIC researchers find
4. Antipsychotic treatment of dementia leads to small increase in risk of death
5. Antipsychotic drugs linked to increased risk of death for some elderly Alzheimers patients
6. UIC researchers to develop new drugs to fight bioterrorism
7. Statin drugs may delay progressive artery damage in children
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Experts call for urgent research into anti-epileptic drugs given to children
10. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
11. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2020)... ... March 27, 2020 , ... ... as COVID-19 cases grow by the day, people of all ages are challenged ... have difficulties with social interactions in the best of times—the physical distance mandated ...
(Date:3/28/2020)... , ... March 27, 2020 , ... ... the launch of this March’s edition of “The Fertility Journey.” This campaign will ... of fertility, third-party parenting, and maternal health options. , One in 6 ...
(Date:3/27/2020)... SCOTCH PLAINS, N.J. (PRWEB) , ... March 27, ... ... Associates has been reviewed and approved by NJ Top Docs. Dr. Kubeck has ... the American Board of Orthopaedic Surgery and specializes in Spinal Surgery. , ...
(Date:3/27/2020)... ... 27, 2020 , ... During a time of global distress and concern about the impact of ... UNITE HERE Education and Support Fund in an effort to assist hospitality workers ... represents 300,000 working people in the food service , hotel and ...
(Date:3/22/2020)... ... March 21, 2020 , ... TriageLogic, a leader ... medical organizations, and health centers can use for patient care during the COVID-19 ... medical professionals are working around the clock to implement emergency support solutions for ...
Breaking Medicine News(10 mins):
(Date:3/20/2020)... ... March 20, 2020 , ... Today, in response to Maryland Governor Larry ... public health emergency, Mercy Medical Center sought and received an Emergency Certificate ... acute care unit on the 17th floor of the hospital’s main inpatient facility, The ...
(Date:3/20/2020)... ... March 20, 2020 , ... New Alliance Academy provides its students with the ... as encourages those interested in pursuing tertiary studies to achieve their goal. One of ... the school have a good chance of progressing into college. , New Alliance Academy ...
(Date:3/19/2020)... ... March 19, 2020 , ... As COVID-19 spreads across the ... us to practice social distancing and, in some cases, self-quarantine to help stop the ... people who have underlying mental health issues. , Cindy Gipson, Ph.D., serves as ...
Breaking Medicine Technology:
Cached News: