Antipsychotic treatment of dementia leads to small increase in risk of death

Atypical antipsychotic drugs seem to confer a small increased risk for death when used in people with dementia, concludes a team of researchers from the Keck School of Medicine of the University of Southern California in a meta-analysis of 15 clinical trials published in the October 19 issue of the Journal of the American Medical Association.

Despite this risk, says Lon Schneider, M.D., professor of psychiatry, neurology, and gerontology at the Keck School and the USC Andrus School of Gerontology, physicians, families and patients need to keep in mind that psychosis itself is a very serious issue in dementia. "Aggression, hallucinations and delusions in dementia patients can also shorten a patient's life, and result in poor care and rapid deterioration," Schneider says. "It's a difficult problem with no easy answers."

Led by Schneider, the USC researchers analyzed the results of the 15 trials--nine of which are unpublished--to determine whether there was a correlation between the use of these second-generation drugs (the atypical antipsychotics) and an increased risk for death.

Within the 15 trials, four different atypical antipsychotics were assessed and compared with placebo: aripiprazole, olanzapine, quetiapine and risperidone. The trials looked at a total of 3353 patients who took the antipsychotics, as well as 1757 who had been given placebo, and lasted on average between 10 and 12 weeks.

In the final analysis, more patients taking an atypical antipsychotic died during their trial than did patients taking placebo. There were 118 deaths associated with atypical antipsychotics (3.5 percent of the drug arm of the trials) versus 40 deaths associated with placebo (2.3 percent of the placebo arm of the trials). The difference between those two groups was statistically significant, and resulted in an odds ratio of death on antipsychotics versus placebo of 1.54 to 1; in other words, the risk of death is 1.54 times greater for people taki

Contact: Jon Weiner
University of Southern California

Page: 1 2 3

Related medicine news :

1. Antipsychotic drugs increase risk of death in older people with dementia
2. Antipsychotic drugs increase risk of death in older people with dementia
3. Antipsychotic medications used to treat Alzheimers patients found lacking
4. Antipsychotic drug may block addiction, UIC researchers find
5. Antipsychotic drugs linked to increased risk of death for some elderly Alzheimers patients
6. Spot on treatment for acne
7. New treatment boosts muscle function in myasthenia gravis
8. New treatment effective in counteracting cocaine-induced symptoms
9. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
10. Preventive treatments in elderly people needs rethinking
11. Osteoporosis screening and treatment may be cost-effective for selected older men

Post Your Comments:

(Date:9/1/2020)... MESA, Calif. (PRWEB) , ... September 01, 2020 , ... ... the “safe side”, the Cohn Health Institute has taken this time to ... In celebration of its 30th Anniversary, the Cohn Health Institute will be relaunching its ...
(Date:8/31/2020)... OCEAN SPRINGS, Miss. (PRWEB) , ... August 31, ... ... Pharmaceuticals Plus (GCPP) recently donated 1,400 N95 face masks to medical first responders ... company has continued to make donations of personal protective equipment (PPE) medical ...
(Date:8/31/2020)... ... 2020 , ... The pandemic and topsy-turvy economic outlook continues to put financial strain on many ... to trim the fat from our monthly expenses and put more into savings, if possible. ... you have a financial safety net in place in case something were to happen to ...
(Date:8/29/2020)... ... , ... When professor and author Randy Pausch was diagnosed with pancreatic cancer, ... than become melancholic, however, he put together a final lecture in Carnegie Hall in ... a negative situation and turned it into something that inspired millions of people worldwide. ...
(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True North ... Biodefense Indoor Air Protection System that is the first system designed and proven to ... with the filtration system on September 8th. , The IVP Air S1 model ...
Breaking Medicine News(10 mins):
(Date:8/27/2020)... CHAPEL HILL, N.C. (PRWEB) , ... August 27, 2020 , ... ... Jensen, professional football player and sleep apnea patient, is the company’s new spokesperson. , ... on the football field. So, when I found the Bleep DreamPort it was a ...
(Date:8/26/2020)... ... ... AseptiScope, a privately funded San Diego, California based, clinical innovation company, has ... , “AseptiScope is pleased to receive this recognition,” said Kelly Powers, AseptiScope cofounder ... hands, goggles on their eyes, covers on their shoes, and gowns on their bodies ...
(Date:8/26/2020)... ... 2020 , ... Crossroads Hospice & Palliative Care Chief Compliance ... her name. , That’s thanks to her completion of two additional certifications this ... Officer (CPCO.) , The CHC is designed to mitigate compliance-related risks. Being ...
Breaking Medicine Technology:
Cached News: