Aspirin to prevent heart disease is beneficial in a wider ra...( vidual's risk for coronary heart diseas...)

Aspirin to prevent heart disease is beneficial in a wider range of men

vidual's risk for coronary heart disease, including "Heart to Heart," found at www.med-decisions.com, the authors said.

The study used published data from trials of aspirin and statin therapy to model the cost-effectiveness of the therapies in middle-aged men who are at varying levels of risk for heart disease.

"Many trials have shown efficacy of aspirin or statins, but we wanted to analyze the efficacy along with the harms, the costs and effect on quality of life and see how good of a deal these treatments are," Pignone said.

The analysis factored in the risk of side effects such as gastrointestinal bleeding, as well as the reduction in quality of life that occurs when a patient finds it onerous to take a pill every day. The study was limited somewhat by the amount and quality of data available, including limited data on adverse effects, Pignone said.

"We still need more research on some of these issues in order to better guide prevention decisions."

Other authors of the study are Dr. Stephanie Earnshaw of RTI Health Solutions in Research Triangle Park; and Dr. Jeffrey A. Tice and Dr. Mark J. Pletcher, both of the University of California at San Francisco.

Pignone and colleagues plan a future analysis of similar data that applies to women.

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Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
6-Mar-2006

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