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Aspirin use during pregnancy could reduce risk of pre-eclampsia

telet agents produce moderate but consistent reductions in pre-eclampsia and its consequencesThis information should be discussed with women at risk of pre-eclampsia to help them make informed choices about their antenatal care."

In an accompanying comment, Professor James Roberts and Dr Janet Catov, Magee-Women's Research Institute and Departments of Obstetrics Gynecology and Reproductive Sciences and Epidemiology, University of Pittsburgh, Pennsylvania, USA, say:: "There are certain settings in which pre-eclampsia is almost a certainty, including women with pre-eclampsia in more than one pregnancy or women with chronic hypertension and pre-eclampsia in a previous pregnancy. In these settings, aspirin is justified.

"In the more usual setting of risk at about 20%, as in chronic hypertension, multiple gestations, pre-pregnancy diabetes or pre-eclampsia in one previous pregnancy, whether benefits outweigh theoretical long term risks is more difficult to judge."

They add: "Is treating 50 women to prevent one case of pre-eclampsia or one preterm birth worthwhile" Although from a public health perspective, such a number to treat might seem effective, the decision is one that is probably best made individually in consultation with an informed mother."


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Contact: Dr. Lisa Askie
laskie@ctc.usyd.edu.au
61-423-330-089
Lancet
16-May-2007


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