BIDMC investigator receives Novartis Award in Diabetes

BOSTON Endocrinologist Christos S. Mantzoros, MD, Director of the Human Nutrition Research Unit at Beth Israel Deaconess Medical Center (BIDMC), received the 2005 Novartis Award in Diabetes (Young Investigator) in a presentation held June 13, 2005, at the 65th Scientific Sessions of the American Diabetes Association in San Diego, California.

The annual Young Investigator award is sponsored by Novartis Pharmaceuticals to recognize a licensed physician under the age of 45 for innovative, patient-oriented research in the fields of physiology, pathophysiology or epidemiology of diabetes mellitus and its complications.

An Associate Professor of Medicine at Harvard Medical School, Mantzoros is a leader in the field of leptin research whose work has advanced the understanding of leptin as a hormonal mediator of the adaptation to starvation.

In clinical studies published in 2003, Mantzoros demonstrated that low leptin levels are responsible for key starvation-induced changes in neuroendocrine axes in humans, findings that have important implications for women with eating disorders and reproductive abnormalities. His subsequent research published in The New England Journal of Medicine provides valuable insights into the pathophysiology of hypothalamic amenorrhea, suggesting new therapeutic options for this prevalent condition.

"Chris's work is a perfect example of translational research," says BIDMC Chief Academic Officer Jeffrey S. Flier. "By applying the novel discoveries made in his lab to clinical studies of women suffering from amenorrhea, Chris has demonstrated that low leptin levels are indeed responsible for reproductive and neuroendocrine abnormalities. These findings are now leading to improved treatments for conditions affecting millions of women worldwide."

Mantzoros has additionally focused attention on the study of low-leptin states among HIV-positive patients, demonstrating that leptin replacement can ameliorate the

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

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