HOME >> MEDICINE >> NEWS
Bacteria could make new library of cancer drugs that are too complex to create artificially

Researchers at the University of Warwick are examining a way of using bacteria to manufacture a new suite of potential anti-cancer drugs that are difficult to create synthetically on a lab bench.

The bacterium Streptomyces coelicolor naturally produce antibiotics called prodiginines.

This group of antibiotics has stimulated much recent interest as they can be used to target and kill cancer cells. A synthetic prodiginine analogue called GX15-070 is currently in phase 1 and 2 cancer treatment trials. However, analogues of other prodiginines, such as streptorubin B, could be even more powerful anti cancer tools, but they cannot currently be easily synthetically produced on a lab bench.

Professor Greg Challis and colleagues in the Chemistry Department of the University of Warwick have looked at the enzymes controlling the process that allows the bacterium Streptomyces coelicolor to create streptorubin B and have gained a clear understanding of which are the key enzymes that act at particular steps of that process. By manipulation of the enzyme content of the bacteria, they aim to produce a range of different compounds based closely on the form of streptorubin B normally formed by the bacteria. Some of these analogues of streptorubin B could provide the basis for developing useful new anti cancer drugs.

Professor Challis said:

"This approach combines the strengths of conventional organic synthesis, with the synthetic power of biology, to assemble complex and synthetically difficult structures. It could be particularly valuable for generating analogues of streptorubin B with all the promise that holds for the development of new anti cancer drugs"


'"/>

Contact: Peter Dunn
p.j.dunn@warwick.ac.uk
2-47-652-3708
University of Warwick
31-Oct-2006


Page: 1

Related medicine news :

1. Bacteria get off easy in sinus infections
2. Bacterial infection associated with heart attack in young men
3. Seat belt injuries could signal more serious trauma in children
4. Using MRI for diagnosis could help prevent breast cancer progression
5. Metabolic study in mice could lead to good cholesterol boosters
6. Miniature implanted devices could treat epilepsy, glaucoma
7. Health reform bills could improve quality and efficiency, but fall short of national plan
8. Experts predict Tamiflu could halve the pandemic influenza death toll versus no intervention
9. Split the difference: Pill-splitting study looks at cost-saving step that could be used by millions
10. Oxygen trick could see organic costs tumble
11. New study could bring relief to sweltering city slickers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/17/2019)... ... October 17, 2019 , ... Dr. Parsa Mohebi, the ... Angeles and Beverly Hills, is reminding patients interested in undergoing a hair transplant that ... , According to Dr. Mohebi, “The holidays are a time for friends and family ...
(Date:10/15/2019)... Va. (PRWEB) , ... October 15, 2019 , ... ... Complying with FDA’s Most Recent IFU Guidance , **An FDAnews Webinar**, Tuesday, October ... recent Instructions for Use (IFU) guidance have on new drug applications and biologics ...
(Date:10/11/2019)... ... October 11, 2019 , ... Inland Detox, Inc. has just moved ... location has incredible views of the Temecula Valley and it’s the perfect place for ... facility offers both private rooms as well as double occupancy rooms, a 2nd home ...
(Date:10/10/2019)... , ... October 10, 2019 , ... ... Annual Conference, Nutrition 21 was excited to hear the significant results of an ... blood flow impact of Nitrosigine®. The clinical study poster entitled “The Acute Effects ...
(Date:10/8/2019)... ... October 08, 2019 , ... Dr. Amir HagShenas of Silicon ... Jose, CA experience relief from this common and treatable condition. Dr. HagShenas’ goal is ... adults from living with uncomfortable symptoms, including tender and bleeding gums, and to prevent ...
Breaking Medicine News(10 mins):
(Date:10/19/2019)... ... ... Hospital M&A activity held steady with 21 transactions in both the second and ... quarter was down 20% compared with the same period in 2018, when 25 deals ... $5.0 billion, a 291% increase. Year over year, Q3:19 spending was down 41% versus ...
(Date:10/17/2019)... (PRWEB) , ... October 17, 2019 , ... ... a patient receiving the right treatment before it progresses further. With many patients ... resources that can help their correct identification of skin cancer be extremely valuable. ...
(Date:10/11/2019)... ... 11, 2019 , ... The 'W' Initiative, a flagship women ... Health Month. The plans are aimed at improving community awareness on health issues ... to health checks and encouraging healthy lifestyle habits. , Slated to run all ...
Breaking Medicine Technology:
Cached News: