(DALLAS, May 22, 2006)--Researchers at Baylor University Medical Center at Dallas and the Baylor Research Institute have developed a novel technique to deliver insulin genes to the pancreas, the organ that produces the body's insulin. This approach is a major step in the potential treatment of Type I diabetes since patients with the disease do not produce enough insulin on their own. The research results were published in the May 2006 issue of the Proceedings of the National Academy of Sciences.
Insulin is a hormone that allows blood glucose (blood sugar) to enter the cells of the body to be used for energy. The technique, known as ultrasound-targeted microbubble destruction (UTMD), delivers these insulin genes to the organ via microscopic "bubbles." Once the bubbles reach their target, they are burst with ultrasound releasing the insulin genes into the pancreas.
Using UTMD, researchers delivered the bubbles containing human insulin genes into the pancreas of rats and later found that the rat's blood sugar had been subsequently lowered. Another gene that regulates insulin production, known as hexokinase I, was successfully delivered using UTMD as well, and resulted in increased blood insulin and decreased blood sugar in the rats.
"Not only was their blood sugar lowered, but there was no evidence of any damage to the pancreas," says Paul Grayburn, M.D., principal investigator of the study. "Other forms of gene therapy are usually invasive and unlike the UTMD technique, do not target the tissues and organs specifically."
Currently, patients with Type I (juvenile onset) diabetes must inject themselves with insulin daily to keep their blood sugar levels balanced in addition to following strict nutritional guidelines. Dr. Grayburn says that the UTMD technique is one of the most important steps in the development of a successful treatment of diabetes without the need for daily insulin injections.
"Now that we have successfully dPage: 1 2 Related medicine news :1
Contact: Ashley Howland
Baylor Health Care System
. Baylor Research Institute receives $6.2 million grant to establish Center for Lupus Research2
. Baylor Institute for Immunology research receives $3 million grant to create cancer vaccines3
. Stanford researchers find culprit in aging muscles that heal poorly4
. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA5
. Penn researchers discover novel pathway for increasing good cholesterol6
. Theory of facial aging gets a facelift from UT Southwestern researchers7
. UIC researchers to develop new drugs to fight bioterrorism8
. UQ researchers discover some of the oldest forms of life9
. U of M researchers discover new method to combat HIV10
. U of M researchers assess effectiveness of computerized physician order entry system11
. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid