Before dementia's first signs appear, weight-loss rate doubles ...( St. Louis Sept. 8 2006 -- A long-ter...),Health

St. Louis, Sept. 8, 2006 -- A long-term study of the elderly has revealed that their average rate of weight loss doubles in the year before symptoms of Alzheimer's-type dementia first become detectable. The finding may be useful to researchers seeking ways to detect and treat Alzheimer's before it causes irreversible brain damage.

The study is the first to confirm in precise detail a link between weight loss and dementia tentatively identified a decade ago. Researchers report in the September 2006 Archives of Neurology that one year before study volunteers were diagnosed with very mild dementia, their rate of weight loss doubled from 0.6 pounds per year to 1.2 pounds per year. The analysis used data from the Memory and Aging Project at the Alzheimer's Disease Research Center (ADRC) of Washington University School of Medicine in St. Louis.

Alzheimer's researchers are working hard to find biomarkers, indicators that can be used to detect the presence of Alzheimer's before clinical symptoms become obvious. Studies at the ADRC and elsewhere have strongly suggested that if Alzheimer's treatments will ever prevent lasting cognitive damage, they may have to be given to patients before memory loss and other disruptions caused by the disorder are evident.

"A person's weight can vary substantially in a given year, so weight loss alone can't serve as a definite indicator for physicians," says David K. Johnson, Ph.D., research instructor in neurology. "But it's interesting from a biochemical perspective--we don't know why these two phenomena are linked. And weight loss may one day be incorporated into a battery of biomarkers that physicians keep their eyes on for early warning of Alzheimer's-type dementia."

The Memory and Aging Project, which began in 1979, is a long-term study of the links between cognitive health and aging. The project is made possible through the cooperation of hundreds of volunteers age 65 and older who undergo a
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Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
11-Sep-2006