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Biomarkers may provide important information for patients at risk for recurrent ischemic stroke

ed with patients in the lowest quarters for both biologic markers," the researchers found. "Level of sVCAM-1 was similarly predictive of ischemic stroke in patients allocated to placebo and perindopril-based (blood pressure lowering) therapy. Baseline plasma levels of C-reactive protein, homocysteine, renin, and lipids and lipoprotein particle concentration and size did not predict recurrent ischemic stroke risk."

In conclusion the authors write, "Characterization of the mechanisms of ischemic stroke pathogenesis associated with increased sVCAM-1 level may lead to development of therapies that provide benefits additional to those provided by angiotensin-converting enzyme inhibitor-based (ACE-inhibitors), blood pressure lowering therapies."


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Contact: Duncan J. Campbell, M.D., Ph.D.
dcampbell@svi.edu.au
JAMA and Archives Journals
14-Nov-2005


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