HOME >> MEDICINE >> NEWS
Bird flu vaccine additive may stretch supply

Researchers have achieved an effective immune response to an avian influenza vaccine with doses as low as one-quarter of the norm when they added a chemical mixture known as MF59. The research is published in the November 1 issue of Clinical Infectious Diseases, now available online.

MF 59 is an adjuvant--a substance that increases the immune system's ability to respond to a stimulus. For this research, the investigators used inactivated H9N2 influenza vaccines--not the H5N1 virus currently feared as a potential pandemic strain. However, the study does suggest that if the feared pandemic comes to be, adjuvants might be used to extend the vaccine supply. Furthermore, the authors note, H9N2 is itself a pandemic threat.

The researchers vaccinated 96 young adults who were divided into eight groups receiving different dosage levels, half of the groups with and half without the MF59 adjuvant. The volunteers were tested for antibodies at 28 days and 56 days.

"Antibody in the blood to the influenza virus that you're trying to protect against is what protects people from getting the flu," said Robert Atmar, MD, lead author of the study. "What vaccines do is cause the vaccinated person to produce antibodies in their bloodstream. The higher the antibody levels, in general, the more likely people are to be protected from getting ill or from getting infected at all.

"What we found was that when the adjuvant material was included in the vaccine--at all dosage levels--the antibody response was significantly better, and as low as one-quarter the dose worked very well. And a single dose of the adjuvanted vaccine was as good as two doses of the vaccine without the adjuvant." This suggests that adjuvants might be used to stretch a limited vaccine supply and allow vaccination of greater numbers of people.

Neither group experienced serious reactions to the vaccines. However, mild pain or swelling was more common in the adjuvant g
'"/>

Contact: Steve Baragona
sbaragona@idsociety.org
703-299-0412
Infectious Diseases Society of America
25-Sep-2006


Page: 1 2

Related medicine news :

1. Traditional Chinese exercises may increase efficacy of flu vaccine
2. DNA vaccine against multiple sclerosis appears safe, potentially beneficial
3. Study reveals gaps in vaccine financing for underinsured children
4. Trials underway for essential new TB vaccine
5. Hib vaccine: A critical ally in Asias effort to reduce child deaths
6. Progress toward an antitumor vaccine
7. Chemotherapy may enhance the effectiveness of brain tumor vaccines
8. OHSU Cancer Institute shows findings of immunotherapy vaccine in prostate cancer patients
9. International studies show high efficacy for HPV vaccine
10. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates
11. Papillomavirus vaccine could substantially reduce cervical cancer incidence

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/22/2019)... ... May 22, 2019 , ... There are over 2.3 million people with multiple ... MS today and 10,000 new cases are diagnosed each year. The need for precision ... MS is difficult to diagnose and manage due to a lack of identified biomarkers ...
(Date:5/22/2019)... ... May 22, 2019 , ... ... revolutionary Invisalign orthodontics solution to patients with crooked teeth in ... has transformed traditional orthodontics, giving patients more discretion, flexibility, and confidence in ...
(Date:5/22/2019)... SCOTCH PLAINS, N.J. (PRWEB) , ... May 22, 2019 , ... ... Anthony T. Suriano have been providing state-of-the-art orthodontic services at their Bernardsville, Chester, Hackettstown, ... care is both comfortable and convenient at all times. , “Orthodontics is about a ...
(Date:5/21/2019)... ... May 21, 2019 , ... Just in ... today announced the publication of its first children’s story, Everybody Needs a Turn. ... of a young girl, Hanna, as she deals with feeling left out when ...
(Date:5/21/2019)... ... May 21, 2019 , ... White Oak Pediatrics ( http://www.whiteoakpediatrics.com ) urges parents ... , Between January 1, 2019 and May 3, 2019, the Centers for Disease Control ... includes a 60 case jump between April 26 and May 3. In comparison, the ...
Breaking Medicine News(10 mins):
(Date:5/22/2019)... ... May 22, 2019 , ... The ... three well-established healthcare professionals to lead its next three Steven A. Cohen ... has provided much-needed mental health care to more than 11,000 clients, with a ...
(Date:5/22/2019)... ... May 22, 2019 , ... ... Healthcare), today announced the appointment of American Psychiatric Association president-elect Jeffrey Geller, MD ... of the American Psychiatric Association (APA), the largest psychiatric association in the world ...
(Date:5/22/2019)... ... May 22, 2019 , ... Two years ago the European ... culture of risk-based quality management (RBQM) in the pharmaceutical industry. Both new and ... trial portfolios. Cloud-based technology offers several advantages to ensuring companies are compliant with ...
Breaking Medicine Technology:
Cached News: