The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> MEDICINE >> NEWS
Blocking previously unrecognized links between inflammatory systems could make COX-2 inhibitors safe

so formed clumps of COX-2 and iNOS enzymes bound to each other.

The Hopkins team also showed that iNOS first binds to COX-2 and then makes NO. The NO chemically modifies COX-2 by a process called nitrosylation, which stimulates the enzyme to make prostaglandins. In addition, the investigators found that the same part of iNOS that binds to COX-2 also contains the "active site" of the enzyme that makes the NO. Furthermore, when the researchers blocked this dual-purpose section of iNOS, they prevented both iNOS binding to COX-2 and the subsequent activation of COX-2 by NO.

"This tells us that during reactions that cause inflammation, COX-2 and iNOS are attached to each other," Snyder said.

The team also demonstrated that the NO that exists freely in cells cannot stimulate COX-2; rather, only NO generated by iNOS that is bound directly to COX-2 can activate these enzymes to produce prostaglandins.


'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
22-Dec-2005


Page: 1 2 3

Related medicine news :

1. Blocking stress protein decreases Alzheimers peptide in mice
2. Blocking immune cell action increases Alzheimers-associated protein deposits
3. Blocking an inter-generational cycle of obesity
4. Blocking key protein reduces inflammatory markers in metabolic syndrome
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Blocking the Odc gene is effective in preventing cancers
7. New class of HIV drug attacks previously untargeted enzyme
8. Epidemic of multi-drug-resistant tuberculosis may be larger than previously thought
9. Sports cheats beware -- new test detects previously undetectable drug
10. Memory loss affects more of the brain than previously thought
11. Under-diagnosed rage disorder more prevalent than previously thought

Post Your Comments:
(Date:11/25/2009)...oliticalEndorsements,Business,andPressJoinEffortto...ewswire/--Onceagain,theNationalBipolarFoundationan...ingtheir"Safe,tilStable"program,whichisnowbeingwid...rdisorder.Today,theNationalBipolarFoundationreceiv...ityMailfromtheLt.GovernorofLouisianaMitchLandrieu....
(Date:11/25/2009)...ncrease blood pressure? This simple question has ... New Stress-related gene Modulates High Blood Pre...ressure? This simple question has been the focus ...rch has for the first time established a link betw...e response to stress in mice as well as humans. Th...
(Date:11/25/2009)...fulness could lead mothers to overlook needed care...althDay News) -- A mother,s depression can worsen ..., Their six-month study of 262 black mothers and...had more depressive symptoms had more frequent ast... depressive symptoms had less frequent asthma symp...
(Date:11/25/2009)...ON,Va.,Nov.25/PRNewswire-USNewswire/--TheAmericanA...areFraudActof2009,"S.2128,whichisdesignedtosubstan...audinMedicare.ThebillwasintroducedbySen.GeorgeLeMi...ovisionstheAmericanAssociationforHomecareoutlinedi...onproposedtoCongressinFebruary.Thoseprovisionsincl...
(Date:11/25/2009)...ehavior problems that can occur in children with a... treatment plan that includes medication combined ...cording to Yale University researchers and their c...ue of the Journal of the American Academy of Chil...ted by the National Institute of Mental Health (NI...
Breaking Medicine News(10 mins):Health News:First Time-Door is Open for Family Discussion of Bipolar Disorder 2Health News:First Time-Door is Open for Family Discussion of Bipolar Disorder 3Health News:New stress-related gene modulates high blood pressure in mice and men 2Health News:Mom's Depression May Worsen Child's Asthma 2Health News:American Association for Homecare Endorses New U.S. Senate Bill, the 'Prevent Health Care Fraud Act of 2009' 2Health News:Parent training key to improved treatment of behavior problems in children with autism 2
(Date:11/24/2009)...,, MADISON,N.J.,Nov.24/PRNewswire-FirstCall/...d,sleadingproviderofdiagnostictesting,informationa...1stAnnualPiperJaffrayHealthcareConferenceinNewYork...er2,2009at9:30a.m.EasternTime. ,, Duringtheconf...enuegrowthtoapproximate3%,operatingincometoexceed1...
(Date:11/24/2009)...,, POTOMAC,Md.,Nov.24/PRNewswire/--Inadditio...eskihasaddedPhiladelphiajurorstoherThanksgivinggra...choice.Iamsothankfultothem,"shesaidofMonday,sverdi...euticals. ,, Wisneskiisamong12,000womennationwi...fthehormonetherapydrugsPremarinandPrempro.Wisneski...
(Date:11/24/2009)...,, RALEIGH,N.C.,Nov.24/PRNewswire/--Pharmace...ingsolutionsforthepharmaceuticalandbiotechindustry...italMarketplace .Thenew HospitalMarketplace e-cour...Excellence(TM) series,acomprehensiveseriesofe-cour...dmanagedmarketsknowledgeforcommercialprofessionals...
Breaking Medicine Technology:Quest Diagnostics To Speak At The 21st Annual Piper Jaffray Healthcare Conference 2Maryland Woman Thankful for Wyeth Verdicts 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2John Legend and Gap Join 28PRODUCT 29RED 28TM 29 to Help Eliminate AIDS in Africa with Exclusive 28RED 29ZONE Seating at Madison Square Garden 4807 1John Legend and Gap Join 28PRODUCT 29RED 28TM 29 to Help Eliminate AIDS in Africa with Exclusive 28RED 29ZONE Seating at Madison Square Garden 4807 2John Legend and Gap Join 28PRODUCT 29RED 28TM 29 to Help Eliminate AIDS in Africa with Exclusive 28RED 29ZONE Seating at Madison Square Garden 4807 3Online H1N1 Management 3A FairChoice Helps Schools Respond to Infectious Disease on Campus 4806 1Online H1N1 Management 3A FairChoice Helps Schools Respond to Infectious Disease on Campus 4806 2Plainview Milk Products Cooperative Implements New Employee Boot Policy 53425 1Plainview Milk Products Cooperative Implements New Employee Boot Policy 53425 2
Other News:
Women who breastfeed longer have a lower risk of developing type 2 diabetes, according to a study in the November 23/30 issue of JAMA.......Type 2 diabetes mellitus affects about 9 million adult women
...ore likely to develop drinking problems if their m...e findings come from University of Queensland rese...hildren through adulthood as part of one of the wo...cted from 2551 Brisbane mothers and their children...
STANFORD, Calif. - "You can eat your relatives but not your friends," could be the off-kilter credo of a tiny marine invertebrate called a sea squirt that can physically merge with, and parasitize, it
... nature can improve your health and wellbeing, say...wn as ecotherapy: restoring health through contact...es is reported to improve quality of life, write t...s, owls, and raccoons) have been used successfully...
health news:Increased duration of breastfeeding associated with decreased risk of diabetes 2health news:Family habits set drinking path 2health news:Stanford study of sea squirt provides clue to human immune system 2health news:Stanford study of sea squirt provides clue to human immune system 3
............ Columbia researchers have participated in a new study that points toward a potential treatment for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.... The study, l
...ater life seems to be linked to intellectual impai... Journal of Neurology Neurosurgery and Psychiatry....g may protect against Alzheimers disease and demen....In a community survey of an area of North London,...
...vaccination financing may help prevent the scatter...n of children, suggest the results of a New York S... of Rochester School of Medicine and Dentistry and... Atlanta, Ga., compared the immunization policies ...
...to 43,000 deaths in Canada -- nearly 20 per cent -...y, says a researcher at the University of Toronto....tional Population Health Survey and 42 other studi...he impact of spirituality on health using the form...
health news:Researchers identify pathway that may slow the progression of Lou Gehrig's disease 2health news:Vaccination reform may improve consistency of care for children 2